N-acetyltransferase 2

NAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PFR
Identifiers
Aliases	NAT2, AAC2, NAT-2, PNAT, N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase)
External IDs	OMIM: 612182 MGI: 97279 HomoloGene: 115468 GeneCards: NAT2
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p22 Start 18,391,282 bp[1] End 18,401,218 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 B3.2|8 33.38 cM Start 67,933,573 bp[2] End 67,944,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver jejunal mucosa duodenum rectum amniotic fluid appendix smooth muscle tissue secondary oocyte placenta spleen Top expressed in pineal gland blastocyst respiratory epithelium olfactory epithelium morula gastrocnemius muscle liver superior frontal gyrus hippocampus proper anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function arylamine N-acetyltransferase activity transferase activity acetyltransferase activity acyltransferase activity protein binding N-acetyltransferase activity Cellular component cytoplasm cytosol Biological process xenobiotic metabolic process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10 17960 Ensembl ENSG00000156006 ENSMUSG00000025588 UniProt P11245 P50294 RefSeq (mRNA) NM_000015 NM_008673 RefSeq (protein) NP_000006 NP_032699 Location (UCSC) Chr 8: 18.39 – 18.4 Mb Chr 8: 67.93 – 67.94 Mb PubMed search [3] [4]
Wikidata
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N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene.^[5]

Function

This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2.^[6]

Phenotype prediction

The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual).^{[7][8][9][10]}

References

Further reading

External links

• NAT2 human gene location in the UCSC Genome Browser.
• NAT2 human gene details in the UCSC Genome Browser.
• The Arylamine N-acetyltransferase Gene Nomenclature Committee homepage
• PDBe-KB provides an overview of all the structure information available in the PDB for Human Arylamine N-acetyltransferase 2

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 30 July 2023, at 15:14