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N-Methylserotonin

From Wikipedia, the free encyclopedia

N-Methylserotonin
Names
Preferred IUPAC name
3-[2-(Methylamino)ethyl]-1H-indol-5-ol
Other names
Norbufotenin; Nω-Methylserotonin; N-Methyl-5-hydroxytryptamine
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
UNII
  • InChI=1S/C11H14N2O/c1-12-5-4-8-7-13-11-3-2-9(14)6-10(8)11/h2-3,6-7,12-14H,4-5H2,1H3
    Key: ASUSBMNYRHGZIG-UHFFFAOYSA-N
  • InChI=1/C11H14N2O/c1-12-5-4-8-7-13-11-3-2-9(14)6-10(8)11/h2-3,6-7,12-14H,4-5H2,1H3
    Key: ASUSBMNYRHGZIG-UHFFFAOYAK
  • Oc1cc2c(cc1)[nH]cc2CCNC
Properties
C11H14N2O
Molar mass 190.246 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

N-Methylserotonin is a tryptamine alkaloid. Chemically, it is a derivative of serotonin in which a methyl group resides at its alkyl amine. It is also called Nω-methylserotonin (Nω-methyl-5-hydroxytryptamine) to distinguish it from tryptamine-derived compounds in which a methyl group is bonded to the nitrogen atom of the indole group.

N-Methylserotonin is found in plants, animals, and fungi. These include the plants, Actaea racemosa (black cohosh)[1] and Zanthoxylum piperitum,[2] the Green and Golden Bell Frog, Litoria aurea,[3] and Amanita mushrooms.[4] The compound binds to several serotonin receptors, including the 5-HT7 and 5-HT1A receptors, with high affinity (IC50 ≤ 2 nM) and selectivity, and displays agonist activity; besides its direct interaction with the serotonin receptors, N-methylserotonin also acts as a selective serotonin reuptake inhibitor.[1]

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Transcription

Legal Status

United States

N-Methylserotonin is not scheduled at the federal level in the United States,[5] but could be considered an analog (of bufotenin), in which case, sales or possession intended for human consumption could be prosecuted under the Federal Analog Act.

Florida

N-Methylserotonin is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[6]

References

  1. ^ a b Powell, SL; Gödecke, T; Nikolic, D; Chen, SN; Ahn, S; Dietz, B; Farnsworth, NR; Van Breemen, RB; Lankin, DC (2008). "In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent". Journal of Agricultural and Food Chemistry. 56 (24): 11718–26. doi:10.1021/jf803298z. PMC 3684073. PMID 19049296.
  2. ^ Yanase, E; Ohno, M; Harakawa, H; Nakatsuka, SI (2010). "Isolation of N,N-dimethyl and N-methylserotonin 5-O-β-glucosides from immature Zanthoxylum piperitum seeds". Bioscience, Biotechnology, and Biochemistry. 74 (9): 1951–2. doi:10.1271/bbb.100261. PMID 20834148. S2CID 26028576.
  3. ^ McClean, Stephen; Robinson, Robert C.; Shaw, Chris; Smyth, W. Franklin (2002). "Characterization and determination of indole alkaloids in frog-skin secretions by electrospray ionization ion trap mass spectrometry". Rapid Communications in Mass Spectrometry. 16 (5): 346–354. Bibcode:2002RCMS...16..346M. doi:10.1002/rcm.583. PMID 11857717.
  4. ^ Tyler, V. E. Jr.; Groeger, D. (1964). "Amanita alkaloids. II. Amanita citrina and Amanita porphyria". Planta Medica. 12 (4): 397–402. doi:10.1055/s-0028-1100193. S2CID 87540610.
  5. ^ "§1308.11 Schedule I." Archived from the original on 2009-08-27. Retrieved 2014-12-17.
  6. ^ Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL
This page was last edited on 27 March 2024, at 21:50
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