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Kelly Slayton
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Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene.[3]
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosharibonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[3]
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D (April 2008). "Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis". Arthritis and Rheumatism. 58 (4): 1001–9. doi:10.1002/art.23386. PMID18383392.
Labbaye C, Spinello I, Quaranta MT, Pelosi E, Pasquini L, Petrucci E, Biffoni M, Nuzzolo ER, Billi M, Foà R, Brunetti E, Grignani F, Testa U, Peschle C (July 2008). "A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis". Nature Cell Biology. 10 (7): 788–801. doi:10.1038/ncb1741. PMID18568019. S2CID30191805.