Mesoderm development LRP chaperone

MESD

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2I9S, 2KGL, 2KMI, 2RQK, 2RQM, 3OFH

Identifiers

Aliases

MESD, BOCA, MESDC2, mesoderm development candidate 2, mesoderm development LRP chaperone, OI20

External IDs

OMIM: 607783 MGI: 1891421 HomoloGene: 11347 GeneCards: MESD

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q25.1	Start	80,946,289 bp^[1]
Band	15q25.1	End	80,989,828 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7 48.35 cM\|7 D3	Start	83,884,466 bp^[2]
Band	7 48.35 cM\|7 D3	End	83,901,532 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic epithelial cell

pancreatic ductal cell

corpus epididymis

tibia

palpebral conjunctiva

parotid gland

internal globus pallidus

germinal epithelium

visceral pleura

parietal pleura

Top expressed in

saccule

otic placode

supraoptic nucleus

ureter

medullary collecting duct

renal corpuscle

primitive streak

spermatocyte

median eminence

seminiferous tubule

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	low-density lipoprotein particle receptor binding identical protein binding molecular function
Cellular component	plasma membrane endoplasmic reticulum cellular component
Biological process	mesoderm development protein folding Wnt signaling pathway phagocytosis protein localization to cell surface positive regulation of skeletal muscle acetylcholine-gated channel clustering
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23184


67943

Ensembl


ENSG00000117899


ENSMUSG00000038503

UniProt


Q14696


Q9ERE7

RefSeq (mRNA)


NM_015154


NM_023403

RefSeq (protein)


NP_055969


NP_075892 NP_001361019

Location (UCSC)

Chr 15: 80.95 – 80.99 Mb

Chr 7: 83.88 – 83.9 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mesoderm development LRP chaperone, or MESD, is a protein that in humans is encoded by the MESD gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117899 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038503 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
^ Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics. 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
^ "Entrez Gene: MESDC2 mesoderm development candidate 2".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479. S2CID 21839750.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hsieh JC, Lee L, Zhang L, et al. (2003). "Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity". Cell. 112 (3): 355–67. doi:10.1016/S0092-8674(03)00045-X. PMID 12581525.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Veltman IM, Vreede LA, Cheng J, et al. (2005). "Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)". Hum. Mol. Genet. 14 (14): 1955–63. doi:10.1093/hmg/ddi200. PMID 15917269.
Li Y, Lu W, He X, Bu G (2006). "Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd". FEBS Lett. 580 (22): 5423–8. doi:10.1016/j.febslet.2006.09.011. PMID 16989816. S2CID 9683744.

v t e PDB gallery
2i9s: The solution structure of the core of mesoderm development (MESD).

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This page was last edited on 6 January 2024, at 07:18

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References

Further reading