MAN1A2

MAN1A2

Identifiers

MAN1A2, MAN1B, mannosidase alpha class 1A member 2

External IDs

OMIM: 604345 MGI: 104676 HomoloGene: 55982 GeneCards: MAN1A2

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p12	Start	117,367,449 bp^[1]
Band	1p12	End	117,528,872 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F2.2	Start	100,469,524 bp^[2]
Band	3\|3 F2.2	End	100,592,819 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

endothelial cell

Brodmann area 23

parietal pleura

visceral pleura

placenta

superficial temporal artery

corpus epididymis

entorhinal cortex

lactiferous duct

Top expressed in

medial dorsal nucleus

lateral geniculate nucleus

medial geniculate nucleus

molar

spermatocyte

spermatid

olfactory tubercle

ventral tegmental area

subiculum

substantia nigra

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding hydrolase activity hydrolase activity, acting on glycosyl bonds metal ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity
Cellular component	Golgi apparatus extracellular exosome endoplasmic reticulum membrane integral component of membrane Golgi membrane
Biological process	protein glycosylation N-glycan processing lung alveolus development metabolism glycoprotein metabolic process Golgi apparatus mannose trimming respiratory gaseous exchange by respiratory system
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10905


17156

Ensembl


ENSG00000198162


ENSMUSG00000008763

UniProt


O60476


P39098

RefSeq (mRNA)


NM_006699


NM_010763

RefSeq (protein)


NP_006690


NP_034893

Location (UCSC)

Chr 1: 117.37 – 117.53 Mb

Chr 3: 100.47 – 100.59 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB is an enzyme that in humans is encoded by the MAN1A2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198162 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008763 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tremblay LO, Campbell Dyke N, Herscovics A (Jul 1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–595. doi:10.1093/glycob/8.6.585. PMID 9592125.
^ "Entrez Gene: MAN1A2 mannosidase, alpha, class 1A, member 2".

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This page was last edited on 14 August 2023, at 23:42

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References

Further reading