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EB/OHPC was first introduced for medical use in 1955.[6]
Society and culture
Brand names
EB/OHPC has been marketed under brand names including Dos Dias N, Lutes, Ostrolut, Primosiston (or Primosiston Inj. / Injection), Primosiston Fuerte, and Syngynon.[7][8][9]
Availability
EB/OHPC has been mostly discontinued and hence is mostly no longer available.[7][8][9] It remains marketed under the brand names Primosiston in Ecuador and Peru, Dos Dias N in Argentina, and Lutes in Japan.[7][8][9] It was previously marketed under the brand names Ostrolut in Austria; Primosiston (or Primosiston Inj. / Injection) (Schering)[1][2][4] in Argentina, Germany, Mexico, Switzerland, and Venezuela; Primosiston Fuerte in Spain; and Syngynon in Germany, but these formulations have all been discontinued and hence are no longer available in these countries.[7][8][9]
^Kaiser R (2008). "Gestagen-Östrogen-Kombinationen in der Gynäkologie. Zur Geschichte, Dosierung und Anwendung eines Hormonprinzips" [Progestogen-Estrogen Combinations in Gynecology. History, Dosage, and Use of a Hormone Principle]. Geburtshilfe und Frauenheilkunde. 53 (7): 503–513. doi:10.1055/s-2007-1022924. ISSN0016-5751. PMID8370495. Zur kombinierten Anwendung von Gestagen en und Östrogenen stand en zunächst ölgelöstes Östradiolbenzoat und Progesteron zur Verfügung. Das erste derartige Mischpräparat kam in Deutschland 1950 auf den Mark t. Dem Wunsch nach verlän gerter Wirkungsdauer entsprach en dann Kristallmischsuspension en verschiedener Korngröße aus Östradiolmonobenzoat + Progesteron, deren Anwendung sich auf klinische Untersuchungen besch ränkte (83). Ölgelöste Depotpräparate mit Östradiolbenzoat oder -valerat + 17-hydroxyprogesteroncaproat wurden ab 1955 in die Therapie eingeführt (45.46).
^ abcdSweetman SC, ed. (2009). "Sex hormones and their modulators". Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. p. 2082. ISBN978-0-85369-840-1.