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Lusutrombopag

From Wikipedia, the free encyclopedia

Lusutrombopag
Clinical data
Pronunciationloo" soo trom' boe pag
Trade namesMulpleta, Mulpleo
AHFS/Drugs.comMonograph
MedlinePlusa618043
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Identifiers
  • (E)-3-[2,6-Dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC29H32Cl2N2O5S
Molar mass591.54 g·mol−1
3D model (JSmol)
  • CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC
  • InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1 checkY
  • Key:NOZIJMHMKORZBA-KJCUYJGMSA-N checkY
 ☒NcheckY (what is this?)

Lusutrombopag, sold under the brand name Mulpleta among others, is a medication that has been developed for certain conditions that lead to thrombocytopenia (abnormally low platelet counts) such as thrombocytopenia associated with chronic liver disease in patients prior to elective invasive procedures.[1] It is being manufactured and marketed in Japan by Shionogi.[2][3][4] It was approved by the U.S. Food and Drug Administration (FDA) in July 2018, and NICE in January 2020.[5][6]

It was approved for medical use in the European Union in February 2019.[7]

YouTube Encyclopedic

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  • Dr.Gobind Rai Garg discusses the topic - Lusutrombopag
  • FDA approved Mulpleta for thrombocytopenia in adults with chronic liver disease
  • eltrombopag
  • Dr David Kuter How I treat ITP Presentation
  • Dr.Gobind Rai Garg discusses the topic - Glicaprevir and Pibrentasvir

Transcription

References

  1. ^ Shirley M, McCafferty EH, Blair HA (October 2019). "Lusutrombopag: A Review in Thrombocytopenia in Patients with Chronic Liver Disease Prior to a Scheduled Procedure". Drugs. 79 (15): 1689–1695. doi:10.1007/s40265-019-01197-8. PMID 31529283. S2CID 202574131.
  2. ^ Shionogi Receives Marketing and Manufacturing Approval in Japan for Mulpleta Tablets 3mg for Improvement of Thrombocytopenia, September 28, 2015
  3. ^ Shionogi Launches Mulpleta Tablets 3mg In Japan for Improvement of Thrombocytopenia
  4. ^ Lusutrombopag (Mulpleta) for severe thrombocytopenia in patients with chronic liver disease undergoing an elective invasive procedure
  5. ^ "FDA approves lusutrombopag for thrombocytopenia in adults with chronic liver disease". U.S. Food and Drug Administration (FDA). July 31, 2018.
  6. ^ "Overview | Lusutrombopag for treating thrombocytopenia in people with chronic liver disease needing a planned invasive procedure | Guidance | NICE".
  7. ^ "Mulpleo EPAR". European Medicines Agency (EMA). Retrieved 17 June 2020.

External links

  • "Lusutrombopag". Drug Information Portal. U.S. National Library of Medicine.


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This page was last edited on 3 April 2023, at 23:50
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