Kidamycin

Kidamycin
Names

Other names Rubiflavin B
Identifiers
CAS Number	11072-82-5^N
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1988097
ChemSpider	4514106
PubChem CID	5359060
InChI InChI=1S/C39H48N2O9/c1-11-17(2)26-15-25(42)29-18(3)12-23-31(37(29)50-26)36(46)32-30(35(23)45)21(27-14-24(40(7)8)33(43)19(4)48-27)13-22(34(32)44)28-16-39(6,41(9)10)38(47)20(5)49-28/h11-13,15,19-20,24,27-28,33,38,43-44,47H,14,16H2,1-10H3/b17-11+ Key: MFTJRTUKCOVIMD-GZTJUZNOSA-N
SMILES C/C=C(\C)/C1=CC(=O)C2=C(O1)C3=C(C=C2C)C(=O)C4=C(C3=O)C(=C(C=C4C5CC(C(C(O5)C)O)N(C)C)C6CC(C(C(O6)C)O)(C)N(C)C)
Properties
Chemical formula	C₃₉H₄₈N₂O₉
Molar mass	688.818 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Kidamycin is an anthracycline antibiotic with anticancer activity.^[1] It was first synthesized from a strain of streptomyces bacteria isolated from a soil sample.^[2] In clinical trials, Kindamycin showed high effect against gram positive bacteria as well as multiple cancer models including Ehrlich ascites carcinoma, Sarcoma 180, NF-sarcoma, and Yoshida sarcoma.^[3]

References

^ Furukawa, M.; Hayakawa, I.; Ohta, G.; Iitaka, Y. (1 January 1971). "Structure and chemistry of kidamycin". Tetrahedron. 31 (23): 2989–2995. doi:10.1016/0040-4020(75)80324-3.
^ Kanda, N. (Sep 1971). "A new antitumor antibiotic, kidamycin. I. Isolation, purification and properties of kidamycin". The Journal of Antibiotics. 24 (9): 599–606. doi:10.7164/antibiotics.24.599. PMID 5132247.
^ Kanda, Nobuo; Kono, Morihiro; Asano, Kazuo (1972). "A New Antitumor Antibiotic, Kidamycin". The Journal of Antibiotics. 25 (10): 553–556. doi:10.7164/antibiotics.25.553. ISSN 0021-8820. PMID 4648309.

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This page was last edited on 25 February 2023, at 19:41

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References