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Kenneth Offit

From Wikipedia, the free encyclopedia

Kenneth Offit
Born
Kenneth Offit

(1955-02-19) February 19, 1955 (age 69)
New York, New York,
United States
NationalityAmerican
Alma materPrinceton University
Harvard Medical School
Harvard School of Public Health
Known forBRCA2 Research
Spouse
Emily Sonnenblick
​
(m. 1984)​
AwardsAmerican Society of Clinical Oncology-American Cancer Society Award (2013)
Scientific career
FieldsCancer Genetics, Oncology, Medical Research
InstitutionsMemorial Sloan Kettering Cancer Center

Kenneth Offit (born February 19, 1955) is an American cancer geneticist and oncologist. He is currently Chief of the Clinical Genetics Service and the Robert and Kate Niehaus Chair in Inherited Cancer Genomics at Memorial Sloan Kettering Cancer Center.[1] Offit is also a member of the Program in Cancer Biology and Genetics at the Sloan-Kettering Institute and Professor of Medicine and Healthcare Policy and Research at Weill Cornell Medical College.[2] He was previously a member of both the Board of Scientific Counselors of the National Cancer Institute[3] and the Evaluation of Genomic Applications in Practice and Prevention working group of the U.S. Centers for Disease Control.[4]

Offit has been widely recognized for his discoveries with respect to the genetic bases of breast, colorectal, and lymphoid cancers. In 2016, he was elected as a Member of the National Academy of Medicine[5] and appointed to the Roundtable on Genomics and Precision Health.[6] In 2018, he was named a Fellow of the American Society of Clinical Oncology.[7] In 2021, he was elected a fellow of the American Association for the Advancement of Science.[8] In 2023, he received an Ellis Island Medal of Honor for his national professional and civic contributions.[9]

Early life and education

Offit was born in New York City on February 19, 1955, to Sidney Offit and Dr. Avodah K. Offit (née Komito). Offit attended the Browning School and then Princeton University, where he was chairman of Tiger Magazine and later a trustee on the University Board of Trustees.[10][11] In the latter capacity, he worked closely with President William G. Bowen on issues pertaining to Princeton's residential system.[12]

After graduating magna cum laude from Princeton in 1977, Offit completed an M.D. at Harvard Medical School and an M.P.H. at the Harvard School of Public Health.[11]

Career and research

In 1996, after the discovery of the BRCA2 gene, Offit and his research group successfully identified the most common mutation on the gene associated with breast and ovarian cancer among individuals of Ashkenazi Jewish ancestry.[3][13][14] [15][16] In 2002, his clinical team published the first prospective study establishing the role of risk-reducing ovarian surgery in women carrying BRCA1 and BRCA2 mutations.[17][18] Offit's group would go on to discover or describe recurrent mutations causing increased risk for colon and prostate cancer, and, in 2013 and 2015, they described two genetic syndromes of inherited childhood lymphoblastic leukemia.[19]

Offit was honored for his contributions to the prevention and management of cancer with the 2013 American Society of Clinical Oncology-American Cancer Society Award and Lecture.[20][21] He is also the author of a textbook, Clinical Cancer Genetics: Risk Counseling and Management, which received an award in Medical Sciences from the Association of American Publishers.[22]

In March 2018, Offit helped launch the BRCA Founder Outreach Study, which provided free testing for three mutations for all insured people over the age of 25 with at least one grandparent of Ashkenazi heritage.[23]

Personal Life

In 1984, Offit married Emily Sonnenblick. Sonnenblick is a radiologist at Mount Sinai Hospital and the daughter of cardiologist Edmund Sonnenblick.[11] One of their daughters, Anna Offit, is an assistant professor of law at Southern Methodist University.[24]

References

  1. ^ "Kenneth Offit | Memorial Sloan Kettering Cancer Center". Mskcc.org. Retrieved July 1, 2015.
  2. ^ "Offit, Kenneth". Vivo.med.cornell.edu. Retrieved July 1, 2015.
  3. ^ a b "Kenneth Offit | Breast Cancer Research Foundation | BCRF". Bcrfcure.org. June 23, 2014. Retrieved July 16, 2015.
  4. ^ "EGAPP|Working Group: Members". Egappreviews.org. Archived from the original on August 6, 2015. Retrieved July 16, 2015.
  5. ^ "National Academy of Medicine Elects 79 New Members". National Academy of Medicine. Retrieved October 21, 2016.
  6. ^ www.nationalacademies.org https://www.nationalacademies.org/our-work/roundtable-on-genomics-and-precision-health/about#members. Retrieved March 27, 2024. {{cite web}}: Missing or empty |title= (help)
  7. ^ "2018 Fellows of the American Society of Clinical Oncology (FASCO) Recognized During Annual Meeting in Chicago". The ASCO Post. June 3, 2018. Retrieved January 23, 2020.
  8. ^ "Three Memorial Sloan Kettering Cancer Center Faculty Members Elected as 2021 AAAS Fellows | Memorial Sloan Kettering Cancer Center". www.mskcc.org. January 27, 2022. Retrieved September 1, 2022.
  9. ^ "EIHS Medalists". medalists.eihonors.org. Retrieved March 27, 2024.
  10. ^ Princeton Alumni Weekly. Princeton Alumni Weekly. 1976. Retrieved July 17, 2015.
  11. ^ a b c "Dr. Emily Sonnenblick Weds in Darien". The New York Times. June 11, 1984. ISSN 0362-4331. Retrieved July 7, 2015.
  12. ^ Malkiel, Nancy Weiss (November 14, 2023). Changing the Game: William G. Bowen and the Challenges of American Higher Education. Princeton University Press. ISBN 978-0-691-24781-6.
  13. ^ "A revolution at 50; kenneth offit". The New York Times. February 25, 2003. ISSN 0362-4331. Retrieved July 2, 2015.
  14. ^ "20 Years of Progress in Understanding Breast Cancer" (JPG). Mskcc.org. Retrieved July 17, 2015.
  15. ^ Kolata, Gina (October 2, 1996). "2d Breast Cancer Gene Found in Jewish Women". The New York Times. ISSN 0362-4331. Retrieved July 7, 2015.
  16. ^ "Why Choose MSK's Clinical Genetics Service for Genetic Counseling and Testing? | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved April 6, 2024.
  17. ^ Kauff, Noah D.; Satagopan, Jaya M.; Robson, Mark E.; Scheuer, Lauren; Hensley, Martee; Hudis, Clifford A.; Ellis, Nathan A.; Boyd, Jeff; Borgen, Patrick I.; Barakat, Richard R.; Norton, Larry; Castiel, Mercedes; Nafa, Khedoudja; Offit, Kenneth (May 23, 2002). "Risk-Reducing Salpingo-oophorectomy in Women with a BRCA1 or BRCA2 Mutation". New England Journal of Medicine. 346 (21): 1609–1615. doi:10.1056/NEJMoa020119. ISSN 0028-4793. PMID 12023992.
  18. ^ "Dr. Kenneth Offit Receives ASCO-ACS Award for Genomic Discoveries, Larger Social Implications Regarding Cancer Risk | ASCO Annual Meeting". web.archive.org. October 21, 2014. Retrieved March 27, 2024.
  19. ^ "Another Genetic Error Linked to Childhood Leukemia: MedlinePlus". Nlm.nih.gov. Archived from the original on July 16, 2015. Retrieved July 13, 2015.
  20. ^ "Three Memorial-Sloan Kettering Researchers Receive Special Awards by the American Society of Clinical Oncology | Memorial Sloan Kettering Cancer Center". Mskcc.org. May 22, 2013. Retrieved July 1, 2015.
  21. ^ "ASCO - American Cancer Society Award and Lecture". Asco.org. Archived from the original on July 20, 2015.
  22. ^ "Kenneth Offit, MD, MPH - DANA FARBER Master Class Courses for Oncologists". Dfcimasterclass.com. Retrieved July 1, 2015.
  23. ^ Dolsten, Josefin (March 14, 2018). "New study on cancer risk in Ashkenazi Jews aims to be model for genetic testing". The Times of Israel.
  24. ^ "Anna C. Offit". Southern Methodist University, Dedman School of Law.
This page was last edited on 6 April 2024, at 19:35
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