KIN (gene)

KIN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CKK, 2V1N

Identifiers

Aliases

KIN, BTCD, KIN17, Rts2, Kin17 DNA and RNA binding protein

External IDs

OMIM: 601720; MGI: 96676; HomoloGene: 8196; GeneCards: KIN; OMA:KIN - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p14	Start	7,750,962 bp^[1]
Band	10p14	End	7,787,993 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A1	Start	10,085,404 bp^[2]
Band	2\|2 A1	End	10,097,617 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

monocyte

Achilles tendon

ganglionic eminence

left lobe of thyroid gland

popliteal artery

body of pancreas

left uterine tube

ascending aorta

left coronary artery

endothelial cell

Top expressed in

ankle joint

yolk sac

ganglionic eminence

thymus

supraoptic nucleus

morula

ascending aorta

maxillary prominence

secondary oocyte

primitive streak

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA binding double-stranded DNA binding metal ion binding RNA binding protein binding
Cellular component	cytoplasm nuclear matrix intracellular membrane-bounded organelle nucleus nucleoplasm protein-containing complex
Biological process	DNA replication mRNA processing DNA recombination viral process DNA repair cellular response to DNA damage stimulus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22944


16588

Ensembl


ENSG00000151657


ENSMUSG00000037262

UniProt


O60870


Q8K339

RefSeq (mRNA)


NM_012311


NM_025280

RefSeq (protein)


NP_036443


NP_079556

Location (UCSC)

Chr 10: 7.75 – 7.79 Mb

Chr 2: 10.09 – 10.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA/RNA-binding protein KIN17 is a protein that in humans is encoded by the KIN gene.^[5]^[6]

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151657 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037262 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Angulo JF, Rouer E, Mazin A, Mattei MG, Tissier A, Horellou P, Benarous R, Devoret R (Nov 1991). "Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein". Nucleic Acids Res. 19 (19): 5117–23. doi:10.1093/nar/19.19.5117. PMC 328864. PMID 1923796.
^ ^a ^b "Entrez Gene: KIN KIN, antigenic determinant of recA protein homolog (mouse)".

Biard DS, Saintigny Y, Maratrat M, et al. (1997). "Differential expression of the HsKin17 protein during differentiation of in vitro reconstructed human skin" (PDF). Arch. Dermatol. Res. 289 (8): 448–56. doi:10.1007/s004030050220. PMID 9266022. S2CID 25828778.
Kannouche P, Angulo JF (1999). "Overexpression of kin17 protein disrupts nuclear morphology and inhibits the growth of mammalian cells". J. Cell Sci. 112 (19): 3215–24. doi:10.1242/jcs.112.19.3215. PMID 10504327.
Blattner C, Kannouche P, Litfin M, et al. (2000). "UV-Induced stabilization of c-fos and other short-lived mRNAs". Mol. Cell. Biol. 20 (10): 3616–25. doi:10.1128/MCB.20.10.3616-3625.2000. PMC 85654. PMID 10779351.
Kannouche P, Mauffrey P, Pinon-Lataillade G, et al. (2000). "Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans". Carcinogenesis. 21 (9): 1701–10. doi:10.1093/carcin/21.9.1701. PMID 10964102.
Biard DS, Miccoli L, Despras E, et al. (2002). "Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells". J. Biol. Chem. 277 (21): 19156–65. doi:10.1074/jbc.M200321200. PMID 11880372.
Miccoli L, Biard DS, Créminon C, Angulo JF (2002). "Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication". Cancer Res. 62 (19): 5425–35. PMID 12359749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masson C, Menaa F, Pinon-Lataillade G, et al. (2003). "Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 616–21. Bibcode:2003PNAS..100..616M. doi:10.1073/pnas.0236176100. PMC 141045. PMID 12525703.
Despras E, Miccoli L, Créminon C, et al. (2003). "Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells". Radiat. Res. 159 (6): 748–58. Bibcode:2003RadR..159..748D. doi:10.1667/0033-7587(2003)159[0748:DOKAHD]2.0.CO;2. ISSN 0033-7587. PMID 12751957. S2CID 10841640.
Biard DS, Miccoli L, Despras E, et al. (2004). "Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes". Mol. Cancer Res. 1 (7): 519–31. PMID 12754299.
Miccoli L, Biard DS, Frouin I, et al. (2003). "Selective interactions of human kin17 and RPA proteins with chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner". Nucleic Acids Res. 31 (14): 4162–75. doi:10.1093/nar/gkg459. PMC 165974. PMID 12853634.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Miccoli L, Frouin I, Novac O, et al. (2005). "The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins". Mol. Cell. Biol. 25 (9): 3814–30. doi:10.1128/MCB.25.9.3814-3830.2005. PMC 1084281. PMID 15831485.
le Maire A, Schiltz M, Braud S, et al. (2006). "Crystallization and halide phasing of the C-terminal domain of human KIN17". Acta Crystallographica Section F. 62 (Pt 3): 245–8. doi:10.1107/S174430910600409X. PMC 2197188. PMID 16511313.
le Maire A, Schiltz M, Stura EA, et al. (2007). "A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics" (PDF). J. Mol. Biol. 364 (4): 764–76. doi:10.1016/j.jmb.2006.09.033. PMID 17045609.

External links

Overview of all the structural information available in the PDB for UniProt: O60870 (DNA/RNA-binding protein KIN17) at the PDBe-KB.

v t e PDB gallery
2ckk: HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN KIN17 C-TERMINAL DOMAIN CONTAINING A KOW MOTIF KIN17.

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This page was last edited on 17 October 2022, at 11:17

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References

Further reading

External links