Jeremy Gunawardena | |
|---|---|
| Alma mater | University of Cambridge (Ph.D.) |
| Known for | Little b |
| Scientific career | |
| Fields | Systems biology, Mathematical biology, Algebraic topology |
| Institutions | Harvard |
Jeremy Gunawardena, a mathematician and systems biologist, is Associate Professor of Systems Biology at Harvard Medical School. He specializes in cellular signalling and decision making.
YouTube Encyclopedic
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1/2Views:8859 348
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Science Matters with Jeremy Gunawardena
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Computer Science 61B - 2014-03-19: Trees and traversals; Priority queues
Transcription
I love what I do because it allows me to bring mathematics to bear on problems in the real world, particularly in the biological context, and that's very exciting. I love it because it allows me to go exploring in areas between the sciences, where I think there's much to be discovered. And I love it because I get to interact with the most fabulous students. My name's Jeremy Gunawardena. I'm an associate professor in the Department of systems biology at Harvard Medical School. I'm a mathematician by upbringing but the system's biologists now. My lab studies information processing in mammalian cells using a combination of mathematical an experimental methods. When the human genome was worked out a lot of us were tremendously excited that this will be a treasure trove information about how we worked and how it would impact human health. And it turns out to be a lot more complicated, because DNA is a molecule. It's dead. We are alive. And there's an enormous transformation that takes place in going from the information in the DNA to us, and that's what systems biology is all about.
Biography
Gunawardena obtained a PhD in algebraic topology from the University of Cambridge under Frank Adams,[1] after which he spent two years as LE Dickson Instructor at the University of Chicago[2] before returning to Cambridge. He set up the first computer science courses at Chicago. After leading Hewlett-Packard's research team in Europe, he joined the faculty of systems biology at the Harvard Medical School.
Work
Gunawardena focuses on mathematical techniques in systems biology, including models for post-translational modification[3] (multisite phosphorylation, transcription factor binding [4]) and other modeling of systems.
One of his most cited papers, "Multisite protein phosphorylation makes a good threshold but can be a poor switch" in Proceedings of the National Academy of Sciences, [5] has received 280 citations according to Google Scholar.[6]
References
- ^ "Jeremy Harin Charles Gunawardena". Mathematics Genealogy Project. Retrieved January 17, 2022.
- ^ "CDS Lecture Series". isr.umd.edu. Retrieved January 17, 2022.
- ^ Gunawardena, J; Y Xu (2012). "Realistic enzymology for post-translational modification: zero-order ultrasensitivity revisited". J Theor Biol. 311: 139–152. Bibcode:2012JThBi.311..139X. doi:10.1016/j.jtbi.2012.07.012. PMC 3432734. PMID 22828569.
- ^ Gunawardena, J; N Hao; B A Budnik; E K O'Shea (2013). "Tunable signal processing through modular control of transcription factor translocation". Science. 339 (6118): 460–4. Bibcode:2013Sci...339..460H. doi:10.1126/science.1227299. PMC 3746486. PMID 23349292.
- ^ PNAS full text
- ^ "Google Scholar".
External links
This page was last edited on 16 February 2023, at 20:17