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From Wikipedia, the free encyclopedia

Sir

Jeremy Farrar

Jeremy Farrar C0058569 Wellcome Images.jpg
Jeremy Farrar in 2009, portrait via wellcomeimges.org at the Wellcome Trust
Born
Jeremy James Farrar

(1961-09-01) 1 September 1961 (age 59)[1]
Singapore
EducationChurcher's College
Alma mater
AwardsHo Chi Minh Medal[3]
Scientific career
Fields
Institutions
ThesisAnalysis of combinatorial immunoglobin libraries from a myasthenia gravis patient (1997)
InfluencesCheryll Tickle[8][9]
Website

Sir Jeremy James Farrar OBE FRCP FRS FMedSci[3][10] (born 1 September 1961)[1] is a British medical researcher and director of the Wellcome Trust since 2013. He was previously a professor of tropical medicine at the University of Oxford.[1][7][11][12][13][14]

Early life and education

Born in Singapore, Farrar is the youngest of six children in his family. His father taught English and his mother was a writer and artist. Due to his father's work, he spent his childhood in New Zealand, Cyprus and Libya.[15]

Farrar was educated at Churcher's College[citation needed] and University College London Medical School,[8] from where he obtained a Bachelor of Science degree in immunology in 1983 and a Bachelor of Medicine, Bachelor of Surgery degree in 1986.[2] Farrar completed his Doctor of Philosophy degree at the University of Oxford in 1998 on myasthenia gravis.[16]

Career and research

Farrar's research interests are in infectious diseases[8] such as tuberculosis,[17] dengue fever,[18][19][20][21] typhoid fever, malaria, and H5N1 influenza.[4][22][23][24]

From 1996 until 2013, Farrar was Director of the Oxford University Clinical Research Unit in Ho Chi Minh City.[5][25][26][27] In 2004, he and his Vietnamese colleague Tran Tinh Hien identified the re-emergence of the deadly bird flu, or H5N1, in humans.[28][29] He was Professor of Tropical Medicine and Global Health at the University of Oxford from 2000 until 2013.[1]

In 2013, Farrar was appointed Director of the Wellcome Trust.[1] During his time at the Wellcome Trust, with Chris Whitty and Neil Ferguson, he co-authored an article in Nature titled "Infectious disease: Tough choices to reduce Ebola transmission",[30] explaining the UK government's response to Ebola in Sierra Leone, including the proposal to build and support centres where people could self-isolate voluntarily if they suspected that they could have the disease.[31] Together with a number of others, in 2016 he proposed a World Serum Bank as a means of helping combat epidemics.[32]

In addition to his role at the Wellcome Trust, Farrar has served as chair on several advisory boards for governments and global organizations. From 2017 until 2019, he was a member of the German Ministry of Health’s International Advisory Board on Global Health, chaired by Ilona Kickbusch.[33] He is also a member of the Health and Biomedical Sciences International Advisory Council (HBMS IAC) at the Agency for Science, Technology and Research of Singapore.[34] In the United Kingdom, he is part of the Scientific Advisory Group for Emergencies (SAGE), led by Patrick Vallance,[35] and Public Health England’s Serology Working Group.[36] In May 2020, amid the COVID-19 pandemic, he was appointed to the expert advisory group for the UK Government’s Vaccine Task Force.[37]

Farrar co-chaired the World Health Organization’s working group on dengue vaccines from 2015 until 2016.[38][39] In 2017, he was part of the selection committee chaired by Jules A. Hoffmann that chose Stewart Cole as director of the Institut Pasteur.[40] In 2019, he served on The Lancet Commission on Tuberculosis, co-chaired by Eric Goosby, Dean Jamison and Soumya Swaminathan.[41] That same year, he also co-chaired a WHO committee evaluating Ebola therapeutics.[42][43]

Since its inception in 2017, Farrar has been chairing the Scientific Advisory Group of the WHO R&D Blueprint, a global strategy and preparedness plan that allows the rapid activation of research activities during epidemics.[44] Since 2018, he has been serving on the joint World Bank/WHO Global Preparedness Monitoring Board (GPMB), co-chaired by Elhadj As Sy and Gro Harlem Brundtland.[45]

Other activities

Corporate boards

Non-profit organisations

Awards and honours

Farrar is a member of the Royal College of Physicians (MRCP) and a Fellow of the Academy of Medical Sciences (FMedSci). He was appointed Officer of the Most Excellent Order of the British Empire (OBE). His citation on election to the Academy of Medical Sciences reads:[61]

Jeremy Farrar is director of the Wellcome Trust-funded Oxford University Clinical Research Unit. Over the past ten years he has created a remarkable research institute in which his own research productivity has been phenomenal and an impressive training program has been developed. Under his direction the research programme has conducted seminal work on malaria, dengue, typhoid, tetanus, pyogenic and tuberculous meningitis and has become the leading centre for clinical research on avian influenza. These Pivotal clinical and virological studies have identified the dual importance of viral burden and the cytokine response to the lethal pathogenesis of avian influenza, and have described the rapid emergence of resistance to neuraminidase inhibitors. The unit has also conducted important research into Dengue shock syndrome, conducting the only large prospective randomised trials of fluid replacement and has provided an evidence-base for revision of the World Health Organisation classification. His commitment to fighting emerging infectious diseases at their source in developing countries is commendable and his contribution to capacity building in Vietnam and other countries is vital for the future of health care in these regions and serves as a model for others to follow.

Farrar was elected a Fellow of the Royal Society (FRS) in 2015.[10] He was appointed a Knight Bachelor in the 2019 New Year Honours for services to Global Health.[62][63]

Controversy

Farrar was the director of the Wellcome Trust in 2018, when bosses (Mike Stratton) at the Wellcome Sanger Institute were accused of bullying staff.[64]

Personal life

Farrar has been married to Christiane Dolecek, an Austrian-born typhoid researcher, since 1998.[65] They have three children and live in Oxford.[66] Since 2011, the family's Farrar Foundation has focused on providing educational assistance to youth from Vietnam and Nepal.[67]

See also

References

  1. ^ a b c d e Anon (2016). "Farrar, Dr Jeremy James". Who's Who. ukwhoswho.com (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
  2. ^ a b "Jeremy Farrar". antimicrobe.org.
  3. ^ a b "Jeremy Farrar – Epidemiologist". BBC.
  4. ^ a b Woolhouse, Mark; Farrar, Jeremy (2014). "Policy: An intergovernmental panel on antimicrobial resistance". Nature. 509 (7502): 555–7. doi:10.1038/509555a. PMID 24877180.
  5. ^ a b "Oxford University Clinical Research Unit". oucru.org.
  6. ^ The Farrar Foundation, farrarfoundation.org
  7. ^ a b Farrar, J; Cressey, D (2014). "Straight talk with...Jeremy Farrar". Nature Medicine. 20 (2): 112. doi:10.1038/nm0214-112. PMID 24504397.
  8. ^ a b c Jeremy Farrar Interviewed by Jim Al-Khalili on The Life Scientific, 14 July 2014
  9. ^ Tickle, C; Crawley, A; Farrar, J (1989). "Retinoic acid application to chick wing buds leads to a dose-dependent reorganization of the apical ectodermal ridge that is mediated by the mesenchyme". Development. 106 (4): 691–705. PMID 2562664.
  10. ^ a b "Professor Jeremy Farrar OBE FMedSci FRS". London: Royal Society. Archived from the original on 17 November 2015.
  11. ^ Van Noorden, Richard (2013). "Clinician to head Wellcome Trust: Jeremy Farrar to lead one of world's largest research charities". Nature. 497 (7447): 19. Bibcode:2013Natur.497...19V. doi:10.1038/497019a. PMID 23636375.
  12. ^ Maxmen, A. (2009). "Jeremy Farrar: When disaster strikes". Journal of Experimental Medicine. 206 (1): 4–5. doi:10.1084/jem.2061pi. PMC 2626674. PMID 19153250.
  13. ^ Jeremy Farrar publications indexed by the Scopus bibliographic database. (subscription required)
  14. ^ A very Wellcome appointment: Professor Jeremy Farrar, who takes over as director of the Wellcome Trust in October 2013, The Guardian, 25 April 2013
  15. ^ James Ashton (18 January 2015), Jeremy Farrar interview: Wellcome Trust director says 'I'm not a great believer in the power of prayer' The Independent.
  16. ^ Farrar, Jeremy (1997). Analysis of combinatorial immunoglobin libraries from a myasthenia gravis patient (DPhil thesis). University of Oxford. EThOS uk.bl.ethos.339366.
  17. ^ Thwaites, G. E.; Nguyen, N. D.; Nguyen, N. H.; Hoang, H. T.; Do, D. T. T.; Nguyen, N. T. C.; Nguyen, N. Q.; Nguyen, N. T.; Nguyen, N. N.; Nguyen, N. T. N.; Nguyen, N. N.; Nguyen, N. H.; Vu, V. N.; Cao, C. H.; Tran, T. T. H.; Pham, P. P.; Nguyen, N. T.; Stepniewska, K.; White, N. J.; Tran, T. T.; Farrar, J. J. (2004). "Dexamethasone for the Treatment of Tuberculous Meningitis in Adolescents and Adults". New England Journal of Medicine. 351 (17): 1741–1751. doi:10.1056/NEJMoa040573. PMID 15496623.
  18. ^ Tricou, V.; Vu, H. T.; Quynh, N. V.; Nguyen, C. V.; Tran, H. T.; Farrar, J.; Wills, B.; Simmons, C. P. (2010). "Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses". BMC Infectious Diseases. 10: 142. doi:10.1186/1471-2334-10-142. PMC 2895602. PMID 20509940.
  19. ^ Guzman, M. G.; Halstead, S. B.; Artsob, H.; Buchy, P.; Farrar, J.; Gubler, D. J.; Hunsperger, E.; Kroeger, A.; Margolis, H. S.; Martínez, E.; Nathan, M. B.; Pelegrino, J. L.; Simmons, C.; Yoksan, S.; Peeling, R. W. (2010). "Dengue: A continuing global threat". Nature Reviews Microbiology. 8 (12): S7–16. doi:10.1038/nrmicro2460. PMC 4333201. PMID 21079655.
  20. ^ Wills, B. A.; Dung, N. M.; Loan, H. T.; Tam, D. T. H.; Thuy, T. T. N.; Minh, L. T. T.; Diet, T. V.; Hao, N. T.; Chau, N. V.; Stepniewska, K.; White, N. J.; Farrar, J. J. (2005). "Comparison of Three Fluid Solutions for Resuscitation in Dengue Shock Syndrome". New England Journal of Medicine. 353 (9): 877–89. doi:10.1056/NEJMoa044057. PMID 16135832.
  21. ^ Solomon, T.; Dung, N. M.; Vaughn, D. W.; Kneen, R.; Thao, L. T. T.; Raengsakulrach, B.; Loan, H. T.; Day, N. P.; Farrar, J.; Myint, K. S.; Warrell, M. J.; James, W. S.; Nisalak, A.; White, N. J. (2000). "Neurological manifestations of dengue infection". The Lancet. 355 (9209): 1053–1059. doi:10.1016/S0140-6736(00)02036-5. PMID 10744091.
  22. ^ Farrar, J. (2012). "H5N1 surveillance: Shift expertise to where it matters". Nature. 483 (7391): 534–535. Bibcode:2012Natur.483..534F. doi:10.1038/483534a. PMID 22460881.
  23. ^ Hien, T. T.; Nguyen, N. T.; Nguyen, N. T.; Luong, L. T.; Pham, P. P.; Nguyen, N. V. V.; Pham, P. T.; Vo, V. C.; Le, L. T. Q.; Ngo, N. T.; Dao, D. B.; Le, L. P.; Nguyen, N. T.; Hoang, H. T.; Cao, C. V.; Le, L. T.; Nguyen, N. D.; Le, L. H.; Nguyen, N. T. K.; Le, L. H.; Le, L. V.; Christiane, C.; Tran, T. T.; Menno De, M.; Schultsz, C.; Cheng, P.; Lim, W.; Horby, P.; Farrar, J.; World Health Organization International Avian Influenza Investigative Team (2004). "Avian Influenza A (H5N1) in 10 Patients in Vietnam". New England Journal of Medicine. 350 (12): 1179–1188. doi:10.1056/NEJMoa040419. PMID 14985470.
  24. ^ De Jong, M. D.; Simmons, C. P.; Thanh, T. T.; Hien, V. M.; Smith, G. J. D.; Chau, T. N. B.; Hoang, D. M.; Chau, N.; Khanh, T. H.; Dong, V. C.; Qui, P. T.; Cam, B.; Ha Do, D. Q.; Guan, Y.; Peiris, J. S. M.; Chinh, N. T.; Hien, T. T.; Farrar, J. (2006). "Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia". Nature Medicine. 12 (10): 1203–1207. doi:10.1038/nm1477. PMC 4333202. PMID 16964257.
  25. ^ Watts, Geoff (2013). "Jeremy Farrar: Wellcome arrival from southeast Asia". The Lancet. 382 (9899): 1167. doi:10.1016/S0140-6736(13)62047-4. PMID 24095187.
  26. ^ Jeremy Farrar on Connecting your research with society on YouTube
  27. ^ Exchanges at the Frontier: Jeremy Farrar on YouTube
  28. ^ Annie Maccoby Berglof (20 June 2014), At Home with the FT House & Home: Wellcome Trust director Jeremy Farrar Financial Times.
  29. ^ Jeremy Farrar seeks innovative backgrounds to help fight infectious diseases, Wired UK on YouTube
  30. ^ Whitty, Christopher J. M.; Farrar, Jeremy; Ferguson, Neil; Edmunds, W. John; Piot, Peter; Leach, Melissa; Davies, Sally C. (2014). "Infectious disease: Tough choices to reduce Ebola transmission". Nature. 515 (7526): 192–194. Bibcode:2014Natur.515..192W. doi:10.1038/515192a. PMID 25391946.
  31. ^ "Infectious disease: Tough choices to reduce Ebola transmission | Ebola Response Anthropology Platform". www.ebola-anthropology.net. Retrieved 10 March 2020.
  32. ^ Metcalf, C Jessica E.; Farrar, Jeremy; Cutts, Felicity T.; Basta, Nicole E.; Graham, Andrea L.; Lessler, Justin; Ferguson, Neil M.; Burke, Donald S.; Grenfell, Bryan T. (2016). "Use of serological surveys to generate key insights into the changing global landscape of infectious disease". The Lancet. 388 (10045): 728–730. doi:10.1016/S0140-6736(16)30164-7. PMC 5678936. PMID 27059886.
  33. ^ Four new members complete the International Advisory Board on Global Health  Federal Ministry of Health, press release of July 2, 2018.
  34. ^ Health and Biomedical Sciences International Advisory Council (HBMS IAC) Agency for Science, Technology and Research of Singapore.
  35. ^ Mark Landler and Stephen Castle (April 23, 2020), The Secretive Group Guiding the U.K. on Coronavirus New York Times.
  36. ^ List of participants of SAGE and related sub-groups, 7 May 2020 Government of the United Kingdom.
  37. ^ Funding and manufacturing boost for UK vaccine programme Government of the United Kingdom, press release of May 17, 2020.
  38. ^ SAGE Working Group on Dengue Vaccines and Vaccination (March 2015 to August 2016) World Health Organization.
  39. ^ Julie Steenhuysen and Ben Hirschler (13 December 2017), Did Sanofi, WHO ignore warning signals on dengue vaccine? Reuters.
  40. ^ Launch of the recruitment process for the Director of the Institut Pasteur Institut Pasteur, press release of 2 May 2017.
  41. ^ Commissioners The Lancet Commission on TB.
  42. ^ Donald G. McNeil Jr. (12 August 2019), A Cure for Ebola? Two New Treatments Prove Highly Effective in Congo The New York Times.
  43. ^ Sarah Boseley (August 12, 2019), Ebola now curable after trials of drugs in DRC, say scientists The Guardian.
  44. ^ R&D Blueprint Scientific Advisory Group members World Health Organization.
  45. ^ WHO and World Bank Group Join Forces to Strengthen Global Health Security World Bank, press release of 24 May 2018.
  46. ^ Temasek Review 2019: Temasek International Panel Temasek Holdings.
  47. ^ Climate & Health Initiative Planning Committee National Academy of Sciences (NAS).
  48. ^ Appointments and changes to the Genome Research Limited Board Wellcome Trust Sanger Institute, press release of 9 December 2019.
  49. ^ Advisory Board & Senior Sponsors Forward Institute.
  50. ^ GHIT Fund Announces New Council Member Jeremy Farrar Global Health Innovative Technology Fund (GHIT Fund), press release of 8 August 2018.
  51. ^ Clive Cookson (18 January 2017). "Davos launch for coalition to prevent epidemics of emerging viruses". Financial Times. Retrieved 6 March 2020. Billion-dollar programme aims to cut vaccine-development time from 12 years to one
  52. ^ John Cohen (2 September 2016). "New vaccine coalition aims to ward off epidemics". Science. 353 (6303).
  53. ^ About Us Global He@lth 2030 Innovation Task Force.
  54. ^ Strategic Advisory Board Global Alliance for Genomics and Health (GA4GH).
  55. ^ GovernanceGlobal Research Collaboration for Infectious Disease Preparedness (GloPID-R).
  56. ^ Jeremy Farrar Francis Crick Institute.
  57. ^ Office for Strategic Coordination of Health Research (OSCHR) National Health Service.
  58. ^ Editors and Publishers The New England Journal of Medicine.
  59. ^ Strategic Coherence of ODA-funded Research UK Collaborative on Development Research (UKCDR).
  60. ^ Global Advisory Board WomenLift Health.
  61. ^ "Dr Jeremy Farrar OBE FMedSci". London: Academy of Medical Sciences. Archived from the original on 25 September 2014.
  62. ^ "New Year's Honours 2019" (PDF). Government of the United Kingdom. Retrieved 29 December 2018.
  63. ^ "New Years Honours List – United Kingdom". thegazette.co.uk. 28 December 2018. Retrieved 29 December 2018.
  64. ^ "Bosses at leading UK science institute accused of bullying staff".
  65. ^ Annie Maccoby Berglof (20 June 2014), At Home with the FT House & Home: Wellcome Trust director Jeremy Farrar Financial Times.
  66. ^ Annie Maccoby Berglof (20 June 2014), At Home with the FT House & Home: Wellcome Trust director Jeremy Farrar Financial Times.
  67. ^ Katrin Elger and Veronika Hackenbroch (8 December 2014), Epidemics Expert Jeremy Farrar: 'The Most Dangerous Emerging Disease Is Drug Resistance' Der Spiegel.
Cultural offices
Preceded by
Mark Walport
Director of the Wellcome Trust
2013 – date
Incumbent
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