Jacqueline K. Barton (born May 7, 1952 New York City, NY), is an American chemist. She worked as a professor of chemistry at Hunter College (1980–82), and at Columbia University (1983–89) before joining the California Institute of Technology. In 1997 she became the Arthur and Marian Hanisch Memorial Professor of Chemistry and from 2009 to 2019, the Norman Davidson Leadership Chair of the Division of Chemistry and Chemical Engineering at Caltech. She currently is the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry, Emerita.
Barton studies the chemical and physical properties of DNA and their roles in biological activities. The primary focus of her research is transverse electron transport along double-stranded DNA, its implications in the biology of DNA damage and repair, and its potential for materials sciences applications such as targeted chemotherapeutic treatments for cancer. Among many other awards, Barton has received the 2011 National Medal of Science and the 2015 Priestley Medal.
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Jacqueline Barton - 2010 National Medal of Science
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Jacqueline K. Barton - 2019 NAS Award in Chemical Sciences
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JACS in Conversation with Professor Jacqueline K. Barton
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Jacqueline Barton: DNA mediated signaling
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Science and Society: Welcome Remarks - 2/26/2016
Transcription
Barton: That's the little secret...which, I guess, isn't a secret. I do it because I love it, 'cause it's fun. Nar: While others have explored DNA's genetic role, Jacqueline Barton has been discovering its physical properties. Barton: I love structure - three-dimensional structures, and the molecular world has all these beautiful structures and what is more beautiful than the DNA double helix. Nar: It was while studying the ability of metal molecules to serve as DNA reporters that Barton made a significant discovery Barton: In my lab, we were mainly focused on how metal complexes bind to DNA and we're really trying to design molecules that would bind to specific sequences of DNA. These metal complexes carry out electron transfer reactions. Do they do it faster, better, differently in the presence of DNA? And the answer was that they did! Well how are they doing that? Maybe they are being coupled into the DNA helix and shooting an electron through the DNA? Nar: Her pursuit of the answer proved to be grueling, controversial and revolutionary. Barton: We showed that you can carry out a chemical reaction on DNA -- oxidize it, damage the DNA from a distance. Then we started saying "well, gee if we can do that, maybe that happens inside the cell because your DNA is constantly getting damaged but it gets fixed. Nar: Her discoveries have illuminated new ways to characterize DNA damage and how cells repair themselves. Barton: Within each of our cells, we have this exquisite repair machinery that's always finding the mistakes that are generated all the time and fixing those mistakes. But it's like finding a needle in a haystack and we don't have a lot of those proteins and they're not all that terribly specific for individuals mistakes. So how do they find the needle in a haystack, find the mistake? We think like telephone repairman they send a signal to each other across the genome across the DNA and that's how they hone in on the mistake. So what's in the future is actually thinking about if they're talking to anybody else on the line if maybe these repair proteins also were talking to other proteins that are involved in maintenance of the genome.
Early life and education
Jacqueline Ann Kapelman was born on May 7, 1952, in New York City. Her father served in the Assembly for nearly a decade before serving as a trial judge in the New York Supreme Court next two decades. Her father was one of the trial judges in the Son of Sam serial murder case.[7]
Jacqueline Kapelman attended Riverdale Country School for Girls in Riverdale, New York, where her math teacher, Mrs. Rosenberg, insisted that she be allowed to take calculus at the boys' school. Her interest in chemistry began at Barnard College, where she studied physical chemistry with Bernice Segal. She loved laboratory work and chemical transformations and found Segal an inspiration as a teacher.[8][9] During her last year at Barnard she married first year medical student Donald J. Barton,[10][5] receiving her B.A. from Barnard College as Jacqueline Kapelman Barton, summa cum laude, in 1974.
She then studied inorganic chemistry at Columbia University under the supervision of Stephen J. Lippard.[11][12][13] While at Columbia she began studying transition-metal complexes and their possible applications to chemotherapy.[8] She earned a PhD in Inorganic Chemistry in 1979, addressing The structure and chemical reactivity of a blue platinum complex: the interaction of antitumor platinum drugs and metallointercalation reagent with nucleic acids.[14]
Career and research
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 "Nature uses this for long-range signalling and finding mistakes in DNA", Jacqueline Barton: DNA like wire for signaling within a cell, EarthSky & Chemical Heritage Foundation | |
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 "Science is the most fun in the whole wide world", Medal of Science 50 Videos – Peter Dervan and Jacqueline Barton, National Science Foundation |
After earning her Ph.D. from Columbia in 1979, Barton held post-doctoral appointments at Bell Labs and Yale University, where she worked with Robert G. Shulman. She used nuclear magnetic resonance imaging technology to examine the metabolism of yeast cells.[10] Barton became a professor of chemistry at Hunter College from 1980 to 1982, and began to develop her own laboratory, the Barton Research Group.[10] While at Hunter, she studied the interactions of zinc ions with DNA, and later the interactions of ruthenium(II) and cobalt(III) complexes with DNA. This enabled her to roughly model complexes on a DNA helix and to begin studying the photophysical and photochemical properties related to enantiomers.[8]
In the 1980s, she moved to Columbia University where she taught from 1983 to 1989.[10] She became a full professor in 1986[15] and was the first woman to receive tenure in the chemistry department at Columbia.[8] Her research focused on the use of organo-ruthenium complexes to examine the physical structure of DNA. With Nicholas Turro and Vijay Kumar she studied the interactions of ruthenium phenanthroline complexes and DNA and was able to design binding molecules targeted to specific DNA sequences.[8] Photosensitive ruthenium complexes would glow brightly when they attached to the DNA double helix. When rhodium complexes were attached to the DNA, they would attract the electron causing the glow, and "turn off" the effect. During her time at Columbia, Barton obtained two patents for this method of analyzing DNA structure.[16]
In 1989, Barton moved to Caltech,[15] where her research has focused on charge transport in DNA. By using specially-designed chiral metal complexes as probes of DNA she has been able to study how DNA is damaged and repaired.[15] In DNA-based diagnostic tests, complexes are used to determine whether electrons can flow across the DNA. If an electron could not move along the DNA, the DNA would continue to glow, indicating that there was damage in the DNA genetic molecule.[16]
The research that Barton, Catherine J. Murphy, Megan Núñez and others have done at Caltech has supported the idea of fast long-range electron transfer over DNA, challenging accepted scientific views and causing considerable controversy.[8] Based on years of studies, Barton and her group theorize that DNA operates like a wire, supporting a type of long-range signaling that enables repair proteins to detect and correct mistakes in DNA. This view of DNA is deeper and more dynamic than previous views of DNA as a static library.[17]
Understanding the mediation of electron-transfer chemistry by the DNA double helix has laid a foundation for the development of new diagnostic tools and for the possible design of novel chemotherapeutics.[8][18] Barton, Erik Holmlin, Shana Kelley, and Mike Hill created the company GeneOhm Sciences to explore the development of sensitive diagnostics for detecting DNA mismatches. The company has since been acquired by BD Diagnostics.[8]
Barton has taught more than 100 graduate and postdoctoral students, many of whom are women.[18] Recognized as a "superb role model, not just for young women but for all young scientists",[15] Barton advises others that "the best thing that I can do for women in science is first to do good science".[8] She became the Arthur and Marian Hanisch Memorial Professor of Chemistry in 1997.[19] She was named chair of the Division of Chemistry and Chemical Engineering of California Institute of Technology, effective July 1, 2009.[10]
Barton was a Member of the Board of Directors of Dow Chemical for more than twenty years.[20] She has also served on the Gilead Sciences Scientific Advisory Board (1989–2008) and has been a member of Gilead's Board of Directors since 2018.[10]
In 1990, she married Peter Dervan, a fellow chemist and professor at Caltech,[6] who is also a National Medal of Science winner.[21] She has two children, a daughter, Elizabeth (born in 1991),[22] and a stepson Andrew.[22]
Research summary
Barton introduced the application of transition metal complexes to probe recognition and reactions of double helical DNA. She has designed chiral metal complexes which mimic the properties of DNA-binding proteins, allowing other researchers the capability to simulate and analyze experiments in this nature. Barton additionally established that DNA charge transport chemistry is extremely sensitive to intervening perturbations in the DNA base stack, as with single base mismatches or lesions. This discovery has been a cornerstone for the development of DNA-based electrochemical sensors.
Awards and honors
Barton was awarded the National Medal of Science by Barack Obama in 2011, "For discovery of a new property of the DNA helix, long-range electron transfer, and for showing that electron transfer depends upon stacking of the base pairs and DNA dynamics. Her experiments reveal a strategy for how DNA repair proteins locate DNA lesions and demonstrate a biological role for DNA-mediated charge transfer."[23] Other awards include:
- Alan T. Waterman Award of the National Science Foundation (1985), first woman recipient[16][24]
- Fresenius Award from Phi Lambda Upsilon (1986), first woman recipient[25]
- Eli Lilly Award in Biological Chemistry by the American Chemical Society (1987)[26]
- American Chemical Society Award in Pure Chemistry (1988), first woman recipient[27]
- Mayor of New York's Award in Science and Technology (1988)
- American Chemical Society Baekeland Medal (1991), first woman recipient[28]
- Fellow of the American Academy of Arts and Sciences (1991)[10][29]
- MacArthur Foundation Fellowship (1991)[22]
- Garvan Medal of the American Chemical Society (1992)[30]
- Tolman Award of the American Chemical Society (1994), first woman recipient[31]
- Havinga Medal (1995)[32]
- Paul Karrer Gold Medal (1996), first woman recipient[10][33]
- Skidmore College honorary Doctor of Laws degree (1997)[34]
- Nichols Medal of the American Chemical Society (1997), first woman recipient[35]
- Weizmann Women & Science Award (1998)[36]
- elected American Philosophical Society (2000)[10]
- elected National Academy of Sciences (2002)[10][37]
- Ronald Breslow Award in Biomimetic Chemistry from the American Chemical Society (2003)[38]
- Yale University honorary Doctor of Science degree (2005)[39]
- Hamilton College honorary Doctor of Science degree (2005)[40]
- ACS Gibbs Medal (2006)[41]
- Linus Pauling Award (2007)
- F.A. Cotton Medal for Excellence in Chemical Research of the American Chemical Society (2007)[42]
- National Medal of Science (2011)[17][43]
- elected Institute of Medicine (2012)[44][45]
- Fellow of the American Chemical Society (ACS) (2014)[46]
- Honorary Fellow of the Royal Society of Chemistry (2014)
- American Institute of Chemists Gold Medal (2015)[18]
- Priestley Medal (2015)[15][47]
- Centenary Prize (2018) from the Royal Society of Chemistry[48]
- Fellow of the National Academy of Inventors (2018)[49]
- NAS Award in Chemical Sciences (2019)[50]
- Theodore Richards Award, Northeastern Section, American Chemical Society (2021)
- Welch award in Chemistry ( Welch foundation) (2023)
References
- ^ Jacqueline K. Barton – Chemistry Tree
- ^ Chow, Christine S. (1992). Transition metal complexes as probes for higher-order structure in RNA. caltech.edu (PhD thesis). California Institute of Technology. OCLC 437064763.
- ^ Delaney, Sarah (2004). Oxidative DNA Damage by Long-Range Charge Transport (PhD thesis). doi:10.7907/9Q0X-TZ17. OCLC 654923736. ProQuest 305200014.
- ^ Odom, Duncan T. (2001). The application of metallointercalators in recognition of and charge transport in nucleic acids. caltech.edu (PhD thesis). California Institute of Technology. OCLC 874759941.
- ^ a b "Miss Kapelman Becomes Bride At the St. Regis". The New York Times. November 12, 1973.
The bride is the daughter of Mrs. Claudine Gutchen Kapelman and Justice William Kapelman of the Criminal Branch of the State Supreme Court, Bronx County, and a former Democratic State Assemblyman.
- ^ a b "Meet Jacqueline K. Barton, 2015 Priestley Medalist". Chemical & Engineering News. 93 (12). Mar 23, 2015. Retrieved 2 April 2015.
- ^ Kerr, Peter (November 10, 1984). "William Kapelman, Ex-Judge And A Bronx Assemblyman". The New York Times.
- ^ a b c d e f g h i Barton, Jacqueline K. (March 23, 2015). "A Career In Chemistry". Chemical & Engineering News. 93 (12): 15–19. doi:10.1021/cen-09312-cover2. Retrieved 2 April 2015.
- ^ "Bernice Segal, 59, a Professor of Chemistry". The New York Times. April 11, 1989. Retrieved 2 April 2015.
- ^ a b c d e f g h i j Ghaffari, Elizabeth (2011). Women Leaders at Work: Untold Tales of Women Achieving Their Ambitions. Apress. pp. 115–124. ISBN 978-1-4302-3730-3.
- ^ The Robert A. Welch Foundation Research Bulletin. Houston, Texas: Robert A. Welch Foundation.
- ^ Thompson, Clifford (2007). Current biography yearbook 2006 (67th annual cumulation ed.). New York: H. W. Wilson. p. 23. ISBN 978-0-8242-1074-8.
- ^ "Jacqueline Barton, Ph.D. '79, and Michael L. Lomax, M.A. '72, to Receive Distinguished Achievement Awards at GSAS Convocation Ceremonies". Graduate School of Arts and Sciences of Columbia University. Archived from the original on 2 April 2015. Retrieved 31 March 2015.
- ^ Barton, Jacqueline Ann (1979). The structure and chemical reactivity of a blue platinum complex: The interaction of antitumor platinum drugs and metallointercalation reagent with nucleic acids (Ph.D. thesis). Columbia University. OCLC 504880014 – via ProQuest. Alternate link via Columbia University.
- ^ a b c d e Wilson, Elizabeth K. (June 12, 2014). "Jacqueline Barton Named Priestley Medalist". Chemical & Engineering News. 92 (24): 4. doi:10.1021/cen-09224-notw1. Retrieved 2 April 2015.
- ^ a b c "Chemists devise way to light up DNA, diseases". Columbia University Record. 19 (11). November 19, 1993. Retrieved 2 April 2015.
- ^ a b "Jacqueline Barton: DNA like wire for signaling within a cell". EarthSky. Apr 23, 2012. Retrieved 31 March 2015.
- ^ a b c "Jacqueline K. Barton". Science History Institute. 2016-06-24.
- ^ "Jacqueline K. Barton Ph.D." Bloomberg Business. Retrieved 3 April 2015.
- ^ "Jacqueline K. Barton". Dow. Retrieved 31 March 2015.
- ^ "President Obama Honors Nation's Top Scientists and Innovators". National Science Foundation. October 14, 2011. Retrieved 3 April 2015.
- ^ a b c Angier, Natalie (March 2, 2004). "Scientist at Work/Jacqueline Barton". The New York Times. Retrieved 31 March 2015.
- ^ "President Obama Honors Nation's Top Scientists and Innovators". whitehouse.gov. September 27, 2011. Retrieved 2 April 2015 – via National Archives.
- ^ Blauner, Peter (Jun 17, 1985). "The Right Chemistry". New York Magazine. p. 28. Retrieved 31 March 2015.
- ^ "Award Recipients". Phi Lambda Upsilon. Retrieved 3 April 2015.
- ^ "Eli Lilly Award in Biological Chemistry" (PDF). ACS Division of Biological Chemistry. Archived from the original (PDF) on 9 October 2020. Retrieved 3 April 2015.
- ^ "ACS Award in Pure Chemistry". ACS Chemistry for Life. American Chemical Society (ACS). Retrieved 3 April 2015.
- ^ "Awards". New Jersey Section American Chemical Society. Retrieved 7 April 2015.
- ^ "Book of Members, 1780–2010: Chapter B" (PDF). American Academy of Arts and Sciences. Retrieved May 19, 2011.
- ^ "Francis P. Garvan-John M. Olin Medal". ACS Chemistry for Life. American Chemical Society (ACS). Retrieved 3 April 2015.
- ^ "Tolman Award". SCALACS. Southern California Section of the American Chemical Society. 2006-01-10. Retrieved 7 April 2015.
- ^ "Havinga Medal Laureates". Havinga Foundation.org. Retrieved 7 April 2015.
- ^ "List of Recipients". University of Zurich. Archived from the original on 20 January 2015. Retrieved 7 April 2015.
- ^ "Commencement Speakers at Skidmore (1937 to present)". Skidmore College.
- ^ "Nichols Medalists". New York Section American Chemical Society. Retrieved 7 April 2015.
- ^ "Dr. Jacqueline Barton To Receive 1998 Women & Science Award". EurekaAlert. American Committee for the Weizmann Institute of Science. 1998-04-21. Archived from the original on 2015-04-18. Retrieved 3 April 2015.
- ^ "72 New Members Chosen by Academy". National Academy of Sciences. April 30, 2002.
- ^ "Ronald Breslow Award for Achievement in Biomimetic Chemistry". ACS Chemistry for Life. American Chemical Society (ACS). Retrieved 3 April 2015.
- ^ Martineau, Kim (May 24, 2005). "A Day Of Idealism at Yale". Hartford Courant.
- ^ "Hamilton College Names Honorary Degree Recipients". Hamilton College. September 28, 2005.
- ^ Tindol, Robert (May 16, 2006). "Caltech Chemist Jacqueline Barton Receives Gibbs Medal from American Chemical Society". Caltech. Retrieved 3 April 2015.
- ^ "F.A. Cotton Medal for Excellence in Chemical Research". American Chemical Society Texas A&M University. Retrieved 3 April 2015.
- ^ "Jacqueline Barton (1952– )". National Science Foundation. Retrieved 31 March 2015.
- ^ "Barton Elected to Institute of Medicine". California Institute of Technology. October 14, 2012.
- ^ "IOM Elects 70 New Members, 10 Foreign Associates". National Academy of Sciences. October 14, 2012.
- ^ "Banner year for female nanoscientists honored as 2014 ACS Fellows". Women in Nanoscience Blog. July 22, 2014. Archived from the original on 2 April 2015. Retrieved 1 April 2015.
- ^ Kemsley, Jyllian (March 23, 2015). "Meet Jacqueline K. Barton, 2015 Priestley Medalist". Chemical & Engineering News. 93 (12): 11–14. Retrieved March 30, 2015.
- ^ "2018 Centenary Prize Winner". Royal Society of Chemistry.
- ^ "Two Caltech Chemists Elected to the National Academy of Inventors". California Institute of Technology. December 11, 2018.
- ^ "Jacqueline K. Barton". www.nasonline.org.
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This page was last edited on 12 March 2024, at 20:52