To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

How to transfigure the Wikipedia

Would you like Wikipedia to always look as professional and up-to-date? We have created a browser extension. It will enhance any encyclopedic page you visit with the magic of the WIKI 2 technology.

Try it — you can delete it anytime.

Install in 5 seconds
4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
Great Wikipedia has got greater.
.
Leo
Newton
Brights
Milds

JNJ-10397049

From Wikipedia, the free encyclopedia

JNJ-10397049
Clinical data
ATC code
  • none
Identifiers
  • 1-(2,4-dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-1,3-dioxan-5-yl)urea
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H20Br2N2O3
Molar mass484.188 g·mol−1
3D model (JSmol)
  • BrC1=CC=C(NC(N[C@@H]2[C@H](C3=CC=CC=C3)OC(C)(C)OC2)=O)C(Br)=C1
  • InChI=1S/C19H20Br2N2O3/c1-19(2)25-11-16(17(26-19)12-6-4-3-5-7-12)23-18(24)22-15-9-8-13(20)10-14(15)21/h3-10,16-17H,11H2,1-2H3,(H2,22,23,24)/t16-,17-/m0/s1 ☒N
  • Key:RBKIJGLHFFQHBE-IRXDYDNUSA-N ☒N

JNJ-10397049 is a potent and highly selective OX2 receptor antagonist. In animals, JNJ-10397049 was found to have sleep-promoting effects and to attenuate the reinforcing effects of ethanol.[1][2]

References

  1. ^ Dugovic C, Shelton JE, Aluisio LE, Fraser IC, Jiang X, Sutton SW, et al. (July 2009). "Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat". The Journal of Pharmacology and Experimental Therapeutics. 330 (1): 142–51. doi:10.1124/jpet.109.152009. PMID 19363060. S2CID 5676758.
  2. ^ Shoblock JR, Welty N, Aluisio L, Fraser I, Motley ST, Morton K, et al. (May 2011). "Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement". Psychopharmacology. 215 (1): 191–203. doi:10.1007/s00213-010-2127-x. PMID 21181123. S2CID 28874886.



Stub icon

This sedative-related article is a stub. You can help Wikipedia by expanding it.

This page was last edited on 22 January 2023, at 14:51
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.
Contact WIKI 2
Introduction
Terms of Service
Privacy Policy