Intracellular receptors are globular protein receptors located inside the cell rather than on its cell membrane. The word intracellular means "within or inside a cell." Molecules that cross a cell membrane to bind with a receptor are generally nonpolar and may be relatively small. These molecules are also known as ligands. Hormones that use intracellular receptors include thyroid, aldosterone, and steroid hormones.[1]
Examples are the class of nuclear receptors located in the cell nucleus and cytoplasm and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually intracellular second messengers like inositol trisphosphate (IP3) and extracellular lipophilic hormones like steroid hormones. Some intracrine peptide hormones also have intracellular receptors.
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Intracellular receptor | Nuclear receptor | Nuclear receptor and its mode of action
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Intracellular Receptor Signaling || Type I and Type II Nuclear Receptor Signaling and Structure
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Endocrinology | Receptor Pathways
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Intracellular Receptors
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Intracellular Signaling / Second Messenger System
Transcription
Examples
- transcription factors
- other
See also
References
- ^ Nowicki, Stephen (May 13, 2016). "Chapter 2". Biology (Textbook) (1st ed.). U.S.A.: Houghton Mifflin Harcourt. p. 84. ISBN 978-0544817982.
External links
- Nuclear receptor signalling atlas (NURSA, open-access journal)
This page was last edited on 11 April 2024, at 00:49