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Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.[5]
Chérel M, Sorel M, Lebeau B, et al. (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): 2534–40. doi:10.1182/blood.V86.7.2534.bloodjournal8672534 (inactive 2024-04-02). PMID7670098.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
Chérel M, Sorel M, Apiou F, et al. (1996). "The human interleukin-11 receptor alpha gene (IL11RA): genomic organization and chromosome mapping". Genomics. 32 (1): 49–53. doi:10.1006/geno.1996.0075. PMID8786120.
Van Leuven F, Stas L, Hilliker C, et al. (1996). "Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13". Genomics. 31 (1): 65–70. doi:10.1006/geno.1996.0010. PMID8808281.
Tsimanis A, Shtalrid M, Shvidel L, et al. (2005). "Expression of interleukin-11 receptor in CD38-positive cells from patients with multiple myeloma". Leuk. Lymphoma. 45 (11): 2315–9. doi:10.1080/10428190412331283161. PMID15512823. S2CID27011485.
Hanavadi S, Martin TA, Watkins G, et al. (2006). "Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer". Ann. Surg. Oncol. 13 (6): 802–8. doi:10.1245/ASO.2006.05.028. PMID16614887. S2CID5693500.
This page was last edited on 2 April 2024, at 22:59