To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

Hydroxy alpha sanshool

From Wikipedia, the free encyclopedia

Hydroxy alpha sanshool
HAS-2D.png
Names
IUPAC name
(2E,6Z,8E,10E)-N-(2-hydroxy-2-methylpropyl)dodeca-2,6,8,10-tetraenamide
Identifiers
3D model (JSmol)
ChemSpider
Properties
C16H25NO2
Molar mass 263.381 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Hydroxy-alpha sanshool is a molecule found in plants from the genus Zanthoxylum. It is believed to be responsible for the numbing and tingling sensation caused by eating food cooked with Sichuan peppercorns.

The term sanshool in the compound's name is derived from the Japanese term for the Sichuan pepper, sanshō (山椒) (literally, mountain pepper), to which was appended the suffix -ol, indicating an alcohol.

YouTube Encyclopedic

  • 1/1
    Views:
    29 401
  • ✪ What Makes Sichuan Food So Flavorful? Here Are the Pantry Staples You Should Be Cooking With

Transcription

Mechanism

Though the chemical structure is similar to that of capsaicin, the mechanism of action by which hydroxy-alpha sanshool induces sensations have been a matter of debate. Although the compound is an agonist at the pain-integration channels TRPV1 and TRPA1 as is capsaicin, newer evidence suggests that the tandem pore domain potassium channels KCNK3, KCNK9, and KCNK18 are primarily responsible for the molecule's effects.[1]

Hydroxy-alpha sanshool excites D-hair afferent nerve fibers, a distinct subset of the sensitive light touch receptors in the skin, and targets novel populations of Aβ and C-fiber nerve fibers.[2]

References

  1. ^ Bautista DM, Sigal YM, Milstein AD, Garrison JL, Zorn JA, Tsuruda PR, Nicoll RA, Julius D (July 2008). "Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels". Nat. Neurosci. 11 (7): 772–9. doi:10.1038/nn.2143. PMC 3072296. PMID 18568022.
  2. ^ Lennertz, Richard C; Tsunozaki, Makoto; Bautista, Diana M; Stucky, Cheryl L (24 Mar 2010). "Physiological basis of tingling paresthesia evoked by hydroxy-α-sanshool". J. Neurosci. Society for Neuroscience. 30 (12): 4353–4361. doi:10.1523/JNEUROSCI.4666-09.2010. PMC 2852189.
This page was last edited on 19 March 2019, at 20:19
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.