In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative name is muriate, derived from hydrochloric acid's ancient name: muriatic acid.
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Hydrochloride
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Why Use Hydrochloride In Drugs | Why Hydrochloride is written on packaging | Medicine knowledge
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हर दवा के पीछे Hydrochloride क्यों लिखा होता है / Why Use Hydrochloride In Drugs In Hindi
Transcription
Uses
Converting amines into their hydrochlorides is a common way to improve their water solubility, which can be desirable for substances used in medications.[1] The European Pharmacopoeia lists more than 200 hydrochlorides as active ingredients in medications.[2] These hydrochlorides, compared to free bases, may more readily dissolve in the gastrointestinal tract and be absorbed into the bloodstream more quickly. Additionally, many hydrochlorides of amines have a longer shelf-life than their respective free bases.[citation needed]
Amine hydrochlorides represent latent forms of a more reactive free base. In this regard, formation of an amine hydrochloride confers protection. This effect is illustrated by the hydrochlorides of the amino acids. Glycine methyl ester hydrochloride is a shelf-stable salt that can be readily converted to a reactive glycine methyl ester, a compound that is not shelf-stable.[3][4]
See also
- Chloride, inorganic salts of hydrochloric acid
- Free base (chemistry)
- Quaternary ammonium cation
References
- ^ Stahl, P. Heinrich; Wermuth, Camille G., eds. (2011). Pharmaceutical Salts: Properties, Selection, and Use (2nd ed.). John Wiley & Sons. ISBN 978-3-90639-051-2.
- ^ European Pharmacopoeia 7th Edition 2011, EDQM.
- ^ Myers, Andrew G.; Gleason, James L. (1999). "Asymmetric Synthesis of α-Amino Acids by the Alkylation of Pseudoephedrine Glycinamide: L-Allylglycine and N-BOC-l-Allylglycine". Organic Syntheses. 76: 57. doi:10.15227/orgsyn.076.0057.
- ^ White, James D.; Kranemann, Christian L.; Kuntiyong, Punlop (2002). "4-Methoxycarbonyl-2-methyl-1,3-oxazole". Org. Synth. 79: 244. doi:10.15227/orgsyn.079.0244.
This page was last edited on 29 April 2023, at 02:42