Hyalobarrier

Hyalobarrier is a substance to keep tissue apart post surgery and therefore prevent adhesions. It contains autocross-linked hyaluronan. Highly viscous due to condensation. Hyaluronan is present in cartilage and skin hence there is a natural metabolic pathway for it. This gel is used to separate organs and tissue after surgery. Scientific documentation so far covers the gynaecology speciality. IE Laparoscopic surgery, hysteroscopy/hysteroscopic surgery but also open surgery. According to data in a Cochrane collaboration review barrier agents may be a little more effective in preventing adhesions than no intervention. The Cochrane report also states that the incidence of postsurgical adhesions is as high as 50 to 100%.^[1] In a recent review by C Sutton (University of Surrey, Guilford UK), it is stated that Hyalobarrier is the only anti adhesive substance that has published data for intrauterine use.^[2]

Additional information

• Laparoscopy
• Asherman's syndrome

References

• Mais V, Bracco GL, Litta P, Gargiulo T, Melis GB (May 2006). "Reduction of postoperative adhesions with an auto-crosslinked hyaluronan gel in gynaecological laparoscopic surgery: a blinded, controlled, randomized, multicentre study". Hum. Reprod. 21 (5): 1248–54. doi:10.1093/humrep/dei488. PMID 16439505.

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This page was last edited on 19 July 2023, at 18:41