HP1BP3

HP1BP3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2RQP

Identifiers

Aliases

HP1BP3, HP1-BP74, HP1BP74, heterochromatin protein 1 binding protein 3

External IDs

OMIM: 616072 MGI: 109369 HomoloGene: 7774 GeneCards: HP1BP3

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.12	Start	20,742,679 bp^[1]
Band	1p36.12	End	20,787,323 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D3	Start	137,943,607 bp^[2]
Band	4\|4 D3	End	137,971,994 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

tibia

trabecular bone

parietal pleura

visceral pleura

Achilles tendon

parotid gland

seminal vesicula

germinal epithelium

ganglionic eminence

Top expressed in

renal corpuscle

medullary collecting duct

condyle

ascending aorta

aortic valve

ganglionic eminence

thymus

olfactory bulb

maxillary prominence

fossa

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding nucleosome binding protein binding chromatin binding
Cellular component	nucleosome nucleus chromosome nuclear speck
Biological process	regulation of nucleus size nucleosome assembly heterochromatin organization regulation of transcription, DNA-templated regulation of cell population proliferation cellular response to hypoxia
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


50809


15441

Ensembl


ENSG00000127483


ENSMUSG00000028759

UniProt


Q5SSJ5


Q3TEA8

RefSeq (mRNA)


NM_016287 NM_001372052

NM_001122896 NM_001122897 NM_001285478 NM_001285479 NM_001285480
NM_001285481 NM_010470 NM_001356431 NM_001356432

RefSeq (protein)

NP_057371 NP_001358981 NP_001363716 NP_001363717 NP_001363718
NP_001363719 NP_001363720 NP_001363721 NP_001363722 NP_001363723 NP_001363724 NP_001363725 NP_001363726

NP_001116368 NP_001116369 NP_001272407 NP_001272408 NP_001272409
NP_001272410 NP_034600 NP_001343360 NP_001343361

Location (UCSC)

Chr 1: 20.74 – 20.79 Mb

Chr 4: 137.94 – 137.97 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene.^[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin ^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: heterochromatin protein 1, binding protein 3". Retrieved 2011-08-30.
^ Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC 4344522. PMID 25662603.
^ Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi:10.1074/mcp.M113.034975. PMC 4159643. PMID 24830416.
^ Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel.2009.03.013. PMC 2727917. PMID 19394292.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW (April 2009). "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia". European Archives of Psychiatry and Clinical Neuroscience. 259 (3): 151–63. doi:10.1007/s00406-008-0847-2. PMID 19165527. S2CID 33815571.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW (2009). "In vitro nuclear interactome of the HIV-1 Tat protein". Retrovirology. 6: 47. doi:10.1186/1742-4690-6-47. PMC 2702331. PMID 19454010.

This page was last edited on 20 January 2024, at 13:19

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References

Further reading