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The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggested that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development.[6] Multiple alternatively spliced transcript variants encoding the same protein have been observed, the full-length natures of only some have been determined.[5]
Kook H, Epstein JA (October 2003). "Hopping to the beat. Hop regulation of cardiac gene expression". Trends in Cardiovascular Medicine. 13 (7): 261–4. doi:10.1016/S1050-1738(03)00107-5. PMID14522464.
Asanoma K, Matsuda T, Kondo H, Kato K, Kishino T, Niikawa N, Wake N, Kato H (January 2003). "NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif". Genomics. 81 (1): 15–25. doi:10.1016/S0888-7543(02)00011-3. PMID12573257.
Chen Y, Petersen S, Pacyna-Gengelbach M, Pietas A, Petersen I (2003). "Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer". Oncology. 64 (4): 450–8. doi:10.1159/000070306. PMID12759545. S2CID3205741.
Pauws E, Sijmons GG, Yaka C, Ris-Stalpers C (July 2004). "A novel homeobox gene overexpressed in thyroid carcinoma". Thyroid. 14 (7): 500–5. doi:10.1089/1050725041517020. PMID15307938.
Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ (October 2004). "Association between gene expression profile and tumor invasion in oral squamous cell carcinoma". Cancer Genetics and Cytogenetics. 154 (1): 27–35. doi:10.1016/j.cancergencyto.2004.01.026. PMID15381369.
Asanoma K, Kato H, Inoue T, Matsuda T, Wake N (August 2004). "Analysis of a candidate gene associated with growth suppression of choriocarcinoma and differentiation of trophoblasts". The Journal of Reproductive Medicine. 49 (8): 617–26. PMID15457851.
Americo TA, Chiarini LB, Linden R (June 2007). "Signaling induced by hop/STI-1 depends on endocytosis". Biochemical and Biophysical Research Communications. 358 (2): 620–5. doi:10.1016/j.bbrc.2007.04.202. PMID17498662.
This page was last edited on 27 December 2023, at 22:08