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Graham-Little syndrome

From Wikipedia, the free encyclopedia

Graham-Little syndrome
Other namesGraham Little-Piccardi-Lassueur syndrome
SpecialtyDermatology Edit this on Wikidata

Graham-Little syndrome or Graham Little-Piccardi-Lassueur syndrome is a cutaneous condition characterized by lichen planus-like skin lesions.[1]: 648  It is named after Ernest Graham-Little.[2]

Graham-Little syndrome is more common in women than men and usually presents between the ages 30-70.

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Transcription

Signs and symptoms

Graham-Little syndrome is defined by a follicular spinous papule on the body, scalp, or both, noncicatricial alopecia of the axilla and groin, and patchy cicatricial alopecia of the scalp.[3]

Causes

Although the precise cause of the condition is unknown, as it is thought to be a variation of lichen planus, cell-mediated immunity—a type of immune system—may be a crucial factor in the development of the disease's clinical manifestation.[3] There have only been a few reported isolated cases of androgen insensitivity syndrome (testicular feminization),[4] which has a familial pattern, a link with hepatitis B vaccination,[5] and phenotypically feminine (genetically XY) patients.[6]

Diagnosis

According to histopathology, early lesions of lichen planopilaris exhibit vacuolar alterations in the outer root sheath as well as perifollicular lymphocytic infiltrates at the level of the isthmus and infundibulum. In more advanced cases, there is epithelial atrophy and perifollicular fibrosis at the level of the isthmus and infundibulum, which results in the distinctive hourglass shape. In more advanced cases, the lost hair follicles are replaced with elastic fibers arranged vertically in place of the lost hair follicles.[3]

Treatment

PUVA therapy, cyclosporine, retinoids, topical, intralesional, and systemic corticosteroids, and antimalarials are among the treatment techniques that have been tested.[3]

Epidemiology

Graham-Little syndrome occurs in people between the ages of 30 and 70, with four times as many reports of females experiencing it as males.[3]

See also

References

  1. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  2. ^ Dorland's Illustrated Medical Dictionary (32 ed.). Philadelphia: Elsevier Saunders. 2012. p. 801. ISBN 978-1416062578. Retrieved October 26, 2019.
  3. ^ a b c d e Pai, VaradrajV; Kikkeri, NaveenN; Sori, Tukaram; Dinesh, US (2011). "Graham-Little Piccardi Lassueur syndrome: An unusual variant of follicular lichen planus". International Journal of Trichology. Medknow. 3 (1): 28. doi:10.4103/0974-7753.82129. ISSN 0974-7753. PMC 3129120.
  4. ^ Vega Gutiérrez, J; Miranda‐Romero, A; Pérez Milán, F; Martínez García, G (2004-06-11). "Graham Little–Piccardi–Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization)". Journal of the European Academy of Dermatology and Venereology. Wiley. 18 (4): 463–466. doi:10.1111/j.1468-3083.2004.00945.x. ISSN 0926-9959.
  5. ^ Bardazzi, C. Landi, C. Orlandi, I., F. (1999-03-18). "Graham Little-Piccardi-Lasseur Syndrome Following HBV Vaccination". Acta Dermato-Venereologica. Medical Journals Sweden AB. 79 (1): 93–93. doi:10.1080/000155599750011886. ISSN 0001-5555.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Viglizzo, Gianmaria; Verrini, Anna; Rongioletti, Franco (2004). "Familial Lassueur-Graham-Little-Piccardi Syndrome". Dermatology. S. Karger AG. 208 (2): 142–144. doi:10.1159/000076489. ISSN 1018-8665.

Further reading

  • Celen, Arda; Lo Sicco, Kristen; Lee, Nayoung; Meehan, Shane; Weed, Jason (2023-02-01). "Graham-Little-Piccardi-Lasseur Syndrome: A Case Report". Journal of Drugs in Dermatology. 22 (2): 210–216. doi:10.36849/JDD.6926.
  • László, Fekete Gyula (2013-03-14). "Graham‐Little–Piccardi–Lasseur syndrome: case report and review of the syndrome in men". International Journal of Dermatology. Wiley. 53 (8): 1019–1022. doi:10.1111/j.1365-4632.2012.05672.x. ISSN 0011-9059.

External links

This page was last edited on 18 March 2024, at 05:01
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