Glycerol 2-dehydrogenase (NADP⁺)

In enzymology, a glycerol 2-dehydrogenase (NADP⁺) (EC 1.1.1.156) is an enzyme that catalyzes the chemical reaction

glycerol + NADP⁺ ${\displaystyle \rightleftharpoons }$ glycerone + NADPH + H⁺

Thus, the two substrates of this enzyme are glycerol and NADP⁺, whereas its 3 products are glycerone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is glycerol:NADP⁺ 2-oxidoreductase (glycerone-forming). Other names in common use include dihydroxyacetone reductase, dihydroxyacetone (reduced nicotinamide adenine dinucleotide, phosphate) reductase, dihydroxyacetone reductase (NADPH), DHA oxidoreductase, and glycerol 2-dehydrogenase (NADP⁺). This enzyme participates in glycerolipid metabolism.

References

• Ben-Amotz A, Avron M (1973). "NADP specific dihydroxyacetone reductase from Dunaliella parva". FEBS Lett. 29 (2): 153–5. doi:10.1016/0014-5793(73)80548-4. PMID 4146296.

This page was last edited on 26 August 2023, at 14:20