Glycerol-3-phosphate 1-dehydrogenase (NADP⁺)

In enzymology, a glycerol-3-phosphate 1-dehydrogenase (NADP⁺) (EC 1.1.1.177) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NADP⁺ ${\displaystyle \rightleftharpoons }$ D-glyceraldehyde 3-phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and NADP⁺, whereas its 3 products are D-glyceraldehyde 3-phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NADP⁺ 1-oxidoreductase. Other names in common use include glycerol phosphate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, L-glycerol 3-phosphate:NADP⁺ oxidoreductase, glycerin-3-phosphate dehydrogenase, NADPH-dependent glycerin-3-phosphate dehydrogenase, and glycerol-3-phosphate 1-dehydrogenase (NADP⁺).

References

• Glushankov PE, Epifanova VE, Kolotilova AI (1976). "Pentose phosphate pathway of carbohydrate metabolism and NADP-dependent glycerol 3-phosphate dehydrogenase activity in some white rat tissues". Biokhimiya. 41: 1788–1790.
• Wood T (1974). "Catalysis of pentose phosphate pathway reactions by cytoplasmic fractions from muscle, uterus and liver of the rat, and the presence of a reduced nicotinamide-adenine dinucleotide phosphate-triose phosphate oxidoreductase in rat muscle". Biochem. J. 138 (1): 71–6. PMC 1166176. PMID 4152128.

This page was last edited on 26 August 2023, at 14:20