Gaba type a receptor associated protein like 1

GABARAPL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2L8J, 2R2Q

Identifiers

Aliases

GABARAPL1, APG8-LIKE, APG8L, ATG8, ATG8B, ATG8L, GEC1, GABA type A receptor associated protein like 1

External IDs

OMIM: 607420; MGI: 1914980; HomoloGene: 134420; GeneCards: GABARAPL1; OMA:GABARAPL1 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.2	Start	10,212,458 bp^[1]
Band	12p13.2	End	10,223,128 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 F3	Start	129,510,123 bp^[2]
Band	6\|6 F3	End	129,519,309 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

endothelial cell

middle temporal gyrus

pons

parotid gland

internal globus pallidus

superior frontal gyrus

kidney tubule

orbitofrontal cortex

superior vestibular nucleus

Top expressed in

hypothalamus

hippocampus proper

superior frontal gyrus

kidney

olfactory bulb

cerebellar cortex

renal cortex

testicle

lens

proximal tubule

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	GABA receptor binding Tat protein binding protein binding beta-tubulin binding ubiquitin protein ligase binding
Cellular component	cytoplasm cell body Golgi apparatus membrane intracellular anatomical structure dendrite membrane autophagosome endoplasmic reticulum mitochondrion dendrite cytoplasm microtubule cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle autophagosome membrane cytosol
Biological process	autophagy macroautophagy autophagosome maturation autophagosome assembly autophagy of mitochondrion cellular response to nitrogen starvation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23710


57436

Ensembl


ENSG00000139112


ENSMUSG00000030161

UniProt


Q9H0R8


Q8R3R8

RefSeq (mRNA)


NM_031412 NM_001363598


NM_020590

RefSeq (protein)


NP_113600 NP_001350527


NP_065615

Location (UCSC)

Chr 12: 10.21 – 10.22 Mb

Chr 6: 129.51 – 129.52 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

GABA type A receptor associated protein like 1 is a protein that in humans is encoded by the GABARAPL1 gene. ^[5]

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References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139112 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030161 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GABA type A receptor associated protein like 1". Retrieved 2017-12-21.

Nemos C, Mansuy V, Vernier-Magnin S, Fraichard A, Jouvenot M, Delage-Mourroux R (2003). "Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system". Brain Res. Mol. Brain Res. 119 (2): 216–9. doi:10.1016/j.molbrainres.2003.09.011. PMID 14625090.
Chen C, Li JG, Chen Y, Huang P, Wang Y, Liu-Chen LY (2006). "GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor". J. Biol. Chem. 281 (12): 7983–93. doi:10.1074/jbc.M509805200. PMID 16431922.
Chen Y, Chen C, Kotsikorou E, Lynch DL, Reggio PH, Liu-Chen LY (2009). "GEC1-kappa opioid receptor binding involves hydrophobic interactions: GEC1 has chaperone-like effect". J. Biol. Chem. 284 (3): 1673–85. doi:10.1074/jbc.M808303200. PMC 2615498. PMID 19001416.
Betin VM, Lane JD (2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". J. Cell Sci. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
Berthier A, Seguin S, Sasco AJ, Bobin JY, De Laroche G, Datchary J, Saez S, Rodriguez-Lafrasse C, Tolle F, Fraichard A, Boyer-Guittaut M, Jouvenot M, Delage-Mourroux R, Descotes F (2010). "High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer". Br. J. Cancer. 102 (6): 1024–31. doi:10.1038/sj.bjc.6605568. PMC 2844027. PMID 20197771.
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G (2010). "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"". PLOS Genet. 6 (7): e1001016. doi:10.1371/journal.pgen.1001016. PMC 2900295. PMID 20628624.
Le Grand JN, Chakrama FZ, Seguin-Py S, Fraichard A, Delage-Mourroux R, Jouvenot M, Boyer-Guittaut M (2011). "GABARAPL1 (GEC1): original or copycat?". Autophagy. 7 (10): 1098–107. doi:10.4161/auto.7.10.15904. PMID 21597319.
Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V (2011). "Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1". J. Mol. Biol. 410 (3): 477–87. doi:10.1016/j.jmb.2011.05.003. PMID 21620860.
Jiang S, Wells CD, Roach PJ (2011). "Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1". Biochem. Biophys. Res. Commun. 413 (3): 420–5. doi:10.1016/j.bbrc.2011.08.106. PMC 3411280. PMID 21893048.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 2 December 2023, at 22:28

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