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From Wikipedia, the free encyclopedia

GTF3A
Identifiers
AliasesGTF3A, AP2, TFIIIA, general transcription factor IIIA
External IDsOMIM: 600860 MGI: 1913846 HomoloGene: 55630 GeneCards: GTF3A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002097

NM_025652

RefSeq (protein)

NP_002088

NP_079928

Location (UCSC)Chr 13: 27.42 – 27.44 MbChr 5: 146.89 – 146.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.[5][6]

It was first purified and identified as the first mammalian gene-specific activator by Roeder in 1980,[7] and later characterized by Wolffe and Brown in 1988.

The TFIIIA in Xenopus was the first zinc finger protein discovered.[8]

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Transcription

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122034 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016503 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, et al. (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.
  6. ^ "Entrez Gene: GTF3A general transcription factor IIIA".
  7. ^ Engelke DR, Ng SY, Shastry BS, Roeder RG (Mar 1980). "Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes". Cell. 19 (3): 717–28. doi:10.1016/S0092-8674(80)80048-1. PMID 6153931. S2CID 23955175.
  8. ^ Bruno M, Mahgoub M, Macfarlan TS (December 2019). "The Arms Race Between KRAB-Zinc Finger Proteins and Endogenous Retroelements and Its Impact on Mammals". Annual Review of Genetics. Annual Reviews. 53 (1): 393–416. doi:10.1146/annurev-genet-112618-043717. PMID 31518518. S2CID 202572327.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page was last edited on 9 September 2023, at 06:15
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