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Cell surface A33 antigen is a protein that in humans is encoded by the GPA33gene.[5][6][7]
The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily.[7]
^Ritter G, Cohen LS, Nice EC, Catimel B, Burgess AW, Moritz RL, Ji H, Heath JK, White SJ, Welt S, Old LJ, Simpson RJ (Sep 1997). "Characterization of posttranslational modifications of human A33 antigen, a novel palmitoylated surface glycoprotein of human gastrointestinal epithelium". Biochem Biophys Res Commun. 236 (3): 682–6. doi:10.1006/bbrc.1997.6966. PMID9245713.
Moritz RL, Ritter G, Catimel B, et al. (1998). "Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium". Journal of Chromatography A. 798 (1–2): 91–101. doi:10.1016/S0021-9673(97)01031-5. PMID9542130.
This page was last edited on 3 March 2023, at 20:31