!["Figure 9. National Drug Overdose Deaths Involving Benzodiazepines, by Opioid Involvement—Number Among All Ages, 1999-2021. The figure above is a bar and line graph showing the total number of U.S. overdose deaths involving benzodiazepines from 1999 to 2021. Drug overdose deaths involving benzodiazepines steadily increased from 1,135 in 1999 to 11,537 in 2017 and declined to 9,711 in 2019. Between 2019 and 2021, deaths rose again to 12,499. The bars are overlaid by lines showing the number of deaths involving benzodiazepines in combination with synthetic opioids other than methadone (primarily fentanyl) or without any opioid (Source: CDC WONDER)."](http://upload.wikimedia.org/wikipedia/commons/thumb/2/2e/US_timeline._Drug_overdose_deaths_involving_antidepressants%2C_by_opioid_involvement.jpg/800px-US_timeline._Drug_overdose_deaths_involving_antidepressants%2C_by_opioid_involvement.jpg)
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