!["Figure 6. National Overdose Deaths Involving Stimulants (cocaine and psychostimulants), by Opioid Involvement—Number Among All Ages, 1999-2021. The figure above is a bar and line graph showing the total number of U.S. overdose deaths involving stimulants from 1999 to 2021. Drug overdose deaths rose from 12,122 in 2015 to 53,495 in 2021. The bars are overlaid by lines showing the number of deaths involving stimulants in combination with synthetic opioids other than methadone (primarily fentanyl) or without any opioid. The number of deaths involving stimulants has increased steadily since 2014 regardless of opioid involvement (Source: CDC WONDER)."](http://upload.wikimedia.org/wikipedia/commons/thumb/d/df/Timeline_of_US_overdose_deaths_involving_stimulants_%28cocaine_and_psychostimulants%29%2C_by_opioid_involvement.jpg/800px-Timeline_of_US_overdose_deaths_involving_stimulants_%28cocaine_and_psychostimulants%29%2C_by_opioid_involvement.jpg)
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