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DescriptionHIF Nobel Prize Physiology Medicine 2019 Hegasy ENG.png
Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability.
Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis.
Date
Source
Own work
Author
Dr. Guido Hegasy
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Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability