![Tertiary structure of human Cdk2, determined by X-ray crystallography. Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) that is primarily made up of alpha helices. The ATP substrate is shown as a ball-and-stick model, located deep within the active-site cleft between the two lobes. The phosphates are oriented outward, toward the mouth of the cleft, which is blocked in this structure by the T-loop (highlighted in green). (PDB 1hck)[1]](http://upload.wikimedia.org/wikipedia/commons/thumb/5/5d/Cyclin-dependent_kinase_structure.pdf/page1-540px-Cyclin-dependent_kinase_structure.pdf.jpg)
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Summary
| Description |
Tertiary structure of human Cdk2, determined by X-ray crystallography. Like other protein kinases, Cdk2 is composed of two lobes: a smaller amino-terminal lobe (top) that is composed primarily of beta sheet and the PSTAIRE helix, and a large carboxy-terminal lobe (bottom) that is primarily made up of alpha helices. The ATP substrate is shown as a ball-and-stick model, located deep within the active-site cleft between the two lobes. The phosphates are oriented outward, toward the mouth of the cleft, which is blocked in this structure by the T-loop (highlighted in green). (PDB 1hck)[1] |
| Date | |
| Source | The Cell Cycle. Principles of Control. |
| Author | David O Morgan |
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| current | 02:12, 8 April 2020 |  | 1,350 × 1,500 (4.57 MB) | Rob Hurt | Uploaded a work by David O Morgan from The Cell Cycle. Principles of Control. with UploadWizard |
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