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File:Choline metabolism.svg

From Wikipedia, the free encyclopedia

Original file(SVG file, nominally 650 × 690 pixels, file size: 5 KB)

Summary

Description
Main pathways of choline (Chol) metabolism, synthesis and excretion.

All of the substrates and products of PC→Chol, 3PG→PE and DimethylGly→Glycine are not shown.

Black: main substrates/products

  • 3PG: 3-phosphoglycerate
  • CDP-Chol: cytidine diphosphate-choline
  • Chol: choline
  • xGly: methylglycine (sarcosine), dimethylglycine and trimethylglycine (betaine)
  • GlyBA: glycine betaine aldehyde
  • HCys: homocysteine
  • PC: phosphatidylcholine
  • PChol: phosphocholine
  • PE: phosphatidylethanolamine
  • SAH: S-adenosylhomocysteine
  • SAM: S-Adenosyl methionine

Gray: side substrates/cofactors/other

  • ADP: adenosine diphosphate
  • ATP: adenosine triphosphate
  • B12: cobalamin
  • CMP: cytidine monophosphate
  • CTP: cytidine triphosphate
  • CoA: (acetyl-)coenzyme A
  • DAG: diglyceride
  • NADH: nicotinamide adenine dinucleotide
  • PPi: pyrophosphate
  • THF: (methyl-)tetrahydrofolate

Red: enzymes

  • BADH: betaine-aldehyde dehydrogenase, EC 1.2.1.8
  • BHMT: betaine-homocysteine S-methyltransferase, EC 2.1.1.5
  • CK: choline kinase, EC 2.7.1.32
  • CPCT: choline-phosphate cytidylyltransferase, EC 2.7.7.15
  • CPT: diacylglycerol cholinephosphotransferase, EC 2.7.8.2
  • ChAT: choline acetyltransferase, EC 2.3.1.6
  • ChOx: choline oxidase, EC 1.1.3.17
  • MS: methionine synthase, EC 2.1.1.13
  • PEMT: phosphatidylethanolamine N-methyltransferase, EC 2.1.1.17
  • PLs: phospholipases
  • SAHase: adenosylhomocysteinase, EC 3.3.1.1

Purple: PEMT pathway

Blue: CDP-choline pathway

Adapted from (with added details):

Date
Source Own work
Author 5-HT2AR

Licensing

I, the copyright holder of this work, hereby publish it under the following license:
Creative Commons CC-Zero This file is made available under the Creative Commons CC0 1.0 Universal Public Domain Dedication.
The person who associated a work with this deed has dedicated the work to the public domain by waiving all of their rights to the work worldwide under copyright law, including all related and neighboring rights, to the extent allowed by law. You can copy, modify, distribute and perform the work, even for commercial purposes, all without asking permission.

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current21:38, 22 October 2019Thumbnail for version as of 21:38, 22 October 2019650 × 690 (5 KB)5-HT2ARUser created page with UploadWizard
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Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.