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Summary
| Description |
Critical quality attributes (CQAs) that dictate the performance of the mRNA construct to express the gene of interest efficiently. Five principal CQAs include 5′ capping efficiency and structure; UTR structure, length, and regulatory elements; modification of coding sequence; poly-A-tail properties; mRNA purity. |
| Date | |
| Source | Jackson, N.A.C., Kester, K.E., Casimiro, D. et al. The promise of mRNA vaccines: a biotech and industrial perspective. npj Vaccines 5, 11 (2020). https://doi.org/10.1038/s41541-020-0159-8 |
| Author | Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, and Frank DeRosa |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:16, 12 September 2021 | | 1,895 × 1,103 (111 KB) | Guest2625 | Uploaded a work by Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, and Frank DeRosa from Jackson, N.A.C., Kester, K.E., Casimiro, D. et al. The promise of mRNA vaccines: a biotech and industrial perspective. npj Vaccines 5, 11 (2020). https://doi.org/10.1038/s41541-020-0159-8 with UploadWizard |
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