Erythema multiforme major

Erythema multiforme major
Other names	Erythema multiforme majus^[1]

Micrograph of confluent epidermal necrosis. H&E stain.
Specialty	Dermatology

In dermatology, erythema multiforme major is a form of rash with skin loss or epidermal detachment.

The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.^[2]

According to some sources, there are two conditions included on a spectrum of this same disease process:

Stevens–Johnson syndrome (SJS)
Toxic epidermal necrolysis (TEN) which described by Alan Lyell and previously called Lyell syndrome[5].

In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.^[3]^[4]

However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.^[3]

References

^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
^ Daniel J. Trozak; Dan J. Tennenhouse (1 October 2005). Dermatology skills for primary care: an illustrated guide. Humana Press. pp. 161–. ISBN 978-1-58829-489-0. Archived from the original on 21 June 2013. Retrieved 5 June 2010.
^ ^a ^b "Erythema Multiforme: eMedicine Emergency Medicine". 2019-02-02. Archived from the original on 2010-08-06. {{cite journal}}: Cite journal requires |journal= (help)
^ Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC (January 1993). "Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme". Arch Dermatol. 129 (1): 92–6. doi:10.1001/archderm.129.1.92. PMID 8420497.^{[permanent dead link]}

5. Orphanet Journal of Rare Diseases 2010, 5:39 doi:10.1186/1750-1172-5-39

Urticaria and erythema

Allergic urticaria

Cold urticaria Familial Primary cold contact urticaria Secondary cold contact urticaria Reflex cold urticaria
Heat urticaria Localized heat contact urticaria Solar urticaria
Dermatographic urticaria Vibratory angioedema Pressure urticaria Cholinergic urticaria Aquagenic urticaria

Other urticaria

Erythema multiforme/ drug eruption	Erythema multiforme minor Erythema multiforme major Stevens–Johnson syndrome Toxic epidermal necrolysis panniculitis (Erythema nodosum) Acute generalized exanthematous pustulosis
Figurate erythema	Erythema annulare centrifugum Erythema marginatum Erythema migrans Erythema gyratum repens Annular erythema of infancy
Other erythema	Necrolytic migratory erythema Erythema toxicum Erythroderma Palmar erythema Generalized erythema

This page was last edited on 23 January 2024, at 22:00