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From Wikipedia, the free encyclopedia

Hermann Emil Fischer
Hermann Emil Fischer c1895.jpg
Hermann Emil Fischer
Born
Hermann Emil Louis Fischer

(1852-10-09)9 October 1852
Euskirchen, Rhine Province
Died15 July 1919(1919-07-15) (aged 66)
NationalityGermany
Alma materUniversity of Bonn
University of Strasbourg
Known forStudy of sugars & purines
Awards
Scientific career
FieldsChemistry
InstitutionsUniversity of Munich (1875–81)
University of Erlangen (1881–88)
University of Würzburg (1888–92)
University of Berlin (1892–1919)
Doctoral advisorAdolf von Baeyer[citation needed]
Doctoral studentsAlfred Stock
Otto Diels
Otto Ruff
Walter A. Jacobs
Ludwig Knorr
Oskar Piloty
Julius Tafel

Hermann Emil Louis Fischer FRS FRSE FCS (9 October 1852 – 15 July 1919) was a German chemist and 1902 recipient of the Nobel Prize in Chemistry. He discovered the Fischer esterification. He also developed the Fischer projection, a symbolic way of drawing asymmetric carbon atoms. He never used his first given name, and was known throughout his life simply as Emil Fischer.[2][3][4][5]

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Transcription

Contents

Early years and career

Fischer was born in Euskirchen, near Cologne, the son of Laurenz Fischer, a businessman, and his wife Julie Poensgen. After graduating he wished to study natural sciences, but his father compelled him to work in the family business until determining that his son was unsuitable. Fischer then attended the University of Bonn in 1871, but switched to the University of Strasbourg in 1872.[6] He earned his doctorate in 1874 under Adolf von Baeyer[6] with his study of phthaleins, and was appointed to a position at the university.

After eight years at Strasbourg, he was appointed to the chair of chemistry successively at the universities of Erlangen (1882) and Würzburg (1885). In 1892 he succeeded von Hofmann as professor of chemistry at the University of Berlin.[7]

Research

In 1875, the year following his engagement with von Baeyer, he published his discovery of the organic derivatives of a new compound of hydrogen and nitrogen, hydrazine. He investigated their derivatives, establishing their relation to the diazo compounds, and he noted the readiness with which they entered into combination with other substances, giving origin to a wealth of hitherto unknown compounds. Of such condensation products undoubtedly the most important are the hydrazones, which result from the interaction with aldehydes and ketones. His observations, published in 1886, that such hydrazones, by treatment with hydrochloric acid or zinc chloride, yielded derivatives of indole, the parent substance of indigo, were a confirmation of the views advanced by von Baeyer on the subject of indigo and the many substances related to it.[7]

He next turned to the fuchsine (then called "rosaniline") magenta dyes, and in collaboration with his cousin Otto Fischer, he published papers in 1878 and 1879 which established that these dyes were derivatives of triphenylmethane. Emil Fischer's next research was concerned with compounds related to uric acid. Here the ground had been broken by von Baeyer, but Fischer greatly advanced the field of knowledge of the purines. In 1881 and 1882 he published papers which established the formulae of uric acid, xanthine, caffeine (achieving the first synthesis), theobromine and some other compounds of this group. After purine itself was isolated, a variety of derivatives were prepared, some of which were patented in view of possible therapeutical applications.[7]

Fischer is particularly noted for his work on sugars. Among his early discoveries related to hydrazine was that phenyl hydrazine reacted with sugars to form substances which he named osazones, and which, being highly crystalline and readily formed, served to identify such carbohydrates more definitely than had been previously possible.[7] Later, among other work, he is noted for the organic synthesis of D-(+)-glucose.[8] He showed how to deduce the formulae of the 16 stereoisomeric glucoses, and prepared several stereoisomerides, helping to confirm confirming the Le Bel–Van 't Hoff rule of the asymmetric carbon atom.[7]

In the field of enzymology, Fischer is known for his proposal of "the lock and key" model as a mechanism of substrate binding.

Fischer was also instrumental in the discovery of barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and anesthesia. Along with the physician Josef von Mering, he helped to launch the first barbiturate sedative, barbital, in 1904.[9] He next carried out pioneering work on proteins. By the introduction of new methods, he succeeded in breaking down the complex albumins into amino acids and other nitrogenous compounds, the constitutions of most of which were known, and by bringing about the recombination of these units, he prepared synthetic peptides which approximated to the natural products. His researches made from 1899 to 1906 were published in 1907 with the title Untersuchungen über Aminosauren, Polypeptides und Proteine.[7]

Honours, awards, and legacy

Monument to Emil Fischer in Berlin
Monument to Emil Fischer in Berlin

In 1897 he put forward the idea to create the International Atomic Weights Commission. Fischer was elected a Foreign Member of the Royal Society (ForMemRS) in 1899.[1] He was awarded the 1902 Nobel Prize in chemistry.

Many names of chemical reactions and concepts are named after him:

(Fischer–Tropsch process is named after Franz Emil Fischer a chemist who was no relation, head of the Max Planck Institute for Coal Research in Muelheim.)

References

  1. ^ a b "Fellows of the Royal Society". London: Royal Society. Archived from the original on 16 March 2015.
  2. ^ Horst Kunz (2002). "Emil Fischer – Unequalled Classicist, Master of Organic Chemistry Research, and Inspired Trailblazer of Biological Chemistry". Angewandte Chemie International Edition. 41 (23): 4439–4451. doi:10.1002/1521-3773(20021202)41:23<4439::AID-ANIE4439>3.0.CO;2-6. PMID 12458504.
  3. ^ Lichtenthaler, F. W. (1992). "Emil Fischers Beweis der Konfiguration von Zuckern: eine Würdigung nach hundert Jahren". Angewandte Chemie. 104 (12): 1577–1593. doi:10.1002/ange.19921041204.
  4. ^ Forster, Martin Onslow (1 January 1920). "Emil Fischer memorial lecture". Journal of the Chemical Society, Transactions. 117: 1157–1201. doi:10.1039/CT9201701157.
  5. ^ Biography Biography of Fischer from Nobelprize.org website
  6. ^ a b Farber, Eduard (1970–1980). "Fischer, Emil Hermann". Dictionary of Scientific Biography. 5. New York: Charles Scribner's Sons. pp. 1–5. ISBN 978-0-684-10114-9.
  7. ^ a b c d e f  One or more of the preceding sentences incorporates text from a publication now in the public domainChisholm, Hugh, ed. (1911). "Fischer, Emil". Encyclopædia Britannica. 10 (11th ed.). Cambridge University Press. p. 426.
  8. ^ Fischer, Emil (1890). "Synthese des Traubenzuckers". Berichte der Deutschen Chemischen Gesellschaft. 23: 799–805. doi:10.1002/cber.189002301126.
  9. ^ López-Muñoz, Francisco; Ucha-Udabe, Ronaldo; Alamo, Cecilio (2005). "The history of barbiturates a century after their clinical introduction". Neuropsychiatric Disease and Treatment. 1 (4): 329–43. PMC 2424120. PMID 18568113.

External links

This page was last edited on 6 November 2019, at 18:42
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