EDC3

EDC3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2VC8, 2WAX, 2WAY, 3D3J, 3D3K

Identifiers

Aliases

EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23

External IDs

OMIM: 609842 MGI: 2142951 HomoloGene: 11827 GeneCards: EDC3

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q24.1	Start	74,630,558 bp^[1]
Band	15q24.1	End	74,696,292 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 B	Start	57,615,823 bp^[2]
Band	9\|9 B	End	57,659,782 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

ganglionic eminence

islet of Langerhans

right lobe of thyroid gland

rectum

left lobe of thyroid gland

monocyte

gastrocnemius muscle

popliteal artery

thymus

Top expressed in

primitive streak

hand

otolith organ

yolk sac

utricle

external carotid artery

trigeminal ganglion

internal carotid artery

fossa

condyle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding phosphodiesterase decapping endonuclease activity identical protein binding RNA binding mRNA binding
Cellular component	cytoplasm cytosol membrane P-body cytoplasmic ribonucleoprotein granule
Biological process	P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA phosphodiester bond hydrolysis, endonucleolytic deadenylation-independent decapping of nuclear-transcribed mRNA
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


80153


353190

Ensembl


ENSG00000179151


ENSMUSG00000038957

UniProt


Q96F86


Q8K2D3

RefSeq (mRNA)


NM_001142443 NM_001142444 NM_025083 NM_001351378 NM_001351379


NM_153799

RefSeq (protein)


NP_001135915 NP_001135916 NP_079359 NP_001338307 NP_001338308


NP_722494

Location (UCSC)

Chr 15: 74.63 – 74.7 Mb

Chr 9: 57.62 – 57.66 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.^[5]^[6]^[7]

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179151 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038957 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett. 569 (1–3): 18–26. doi:10.1016/j.febslet.2004.03.126. PMID 15225602.
^ Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res. 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID 17533573. S2CID 10679128.
^ ^a ^b "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC 2169425. PMID 17923697.

Post-transcriptional modification

Nuclear

Precursor mRNA
5′ cap formation
Polyadenylation
- CPSF
- CstF
- PAP
- PAB2
- CFI
- CFII
Poly(A)-binding protein
RNA editing
Polyuridylation

RNA splicing

Intron / Exon snRNP Spliceosome minor U1 Alternative splicing
pre-mRNA factors	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

Cytosolic

5′ cap methylation
mRNA decapping
- DCP1A
- DCP1B
- DCP2
- DCPS
- EDC3
- EDC4

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This page was last edited on 29 March 2024, at 00:28

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References

Further reading