| Combination of | |
|---|---|
| Dolutegravir | HIV integrase strand transfer inhibitor (INSTI) |
| Rilpivirine | HIV non-nucleoside reverse-transcriptase inhibitor (NNRTI) |
| Clinical data | |
| Trade names | Juluca |
| AHFS/Drugs.com | Monograph |
| License data | |
| Pregnancy category | |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| KEGG | |
Dolutegravir/rilpivirine, sold under the brand name Juluca, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS.[8][6] It contains the medicines dolutegravir and rilpivirine.[6] It is taken by mouth.[6]
The most common adverse reactions (of all severity grades) are diarrhea and headache.[6]
Dolutegravir/rilpivirine was approved for use in the United States in November 2017,[6][9][10] and for use in the European Union in May 2018.[7]
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Transcription
Medical uses
Dolutegravir/rilpivirine is indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are virologically suppressed (HIV-1 RNA <50 copies/mL) on a stable antiretroviral regimen for at least six months with no history of virological failure and no known or suspected resistance to any non-nucleoside reverse transcriptase inhibitor or integrase inhibitor.[7]
References
- ^ "Dolutegravir / rilpivirine (Juluca) Use During Pregnancy". Drugs.com. 7 January 2020. Retrieved 25 March 2020.
- ^ a b "TGA eBS - Product and Consumer Medicine Information Licence".
- ^ "Juluca". NPS MedicineWise. 15 July 2021. Retrieved 13 February 2022.
- ^ "Search Page - Drug and Health Product Register". 23 October 2014.
- ^ "Juluca 50 mg/25 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 25 February 2020. Retrieved 25 March 2020.
- ^ a b c d e f "Juluca- dolutegravir sodium and rilpivirine hydrochloride tablet, film coated". DailyMed. 24 October 2019. Retrieved 25 March 2020.
- ^ a b c "Juluca EPAR". European Medicines Agency (EMA). 11 February 2019. Retrieved 25 March 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ Hester EK, Astle K (August 2019). "Dolutegravir-Rilpivirine, Dual Antiretroviral Therapy for the Treatment of HIV-1 Infection". The Annals of Pharmacotherapy. 53 (8): 860–866. doi:10.1177/1060028019831674. PMID 30758229. S2CID 73429093.
- ^ "Drug Approval Package: Juluca (dolutegravir and rilpivirine)". U.S. Food and Drug Administration (FDA). 29 June 2018. Retrieved 25 March 2020.
- ^ "Juluca: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 25 March 2020.
External links
- "Dolutegravir mixture with rilpivirine". Drug Information Portal. U.S. National Library of Medicine.
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This page was last edited on 20 December 2023, at 21:38