dTDP-6-deoxy-L-talose 4-dehydrogenase

In enzymology, a dTDP-6-deoxy-L-talose 4-dehydrogenase (EC 1.1.1.134) is an enzyme that catalyzes the chemical reaction

dTDP-6-deoxy-L-talose + NADP⁺ ${\displaystyle \rightleftharpoons }$ dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H⁺

Thus, the two substrates of this enzyme are dTDP-6-deoxy-L-talose and NADP⁺, whereas its 3 products are dTDP-4-dehydro-6-deoxy-L-mannose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is dTDP-6-deoxy-L-talose:NADP⁺ 4-oxidoreductase. Other names in common use include thymidine diphospho-6-deoxy-L-talose dehydrogenase, TDP-6-deoxy-L-talose dehydrogenase, thymidine diphospho-6-deoxy-L-talose dehydrogenase, and dTDP-6-deoxy-L-talose dehydrogenase (4-reductase). This enzyme participates in nucleotide sugars metabolism.

References

• Gaugler RW, Gabriel O (1973). "Biological mechanisms involved in the formation of deoxy sugars VII. Biosynthesis of 6-deoxy-L-talose". J. Biol. Chem. 248 (17): 6041–9. PMID 4199258.

This page was last edited on 26 August 2023, at 13:56