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| Names | |
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| Preferred IUPAC name
Sodium 3-(trimethylsilyl)propane-1-sulfonate | |
| Other names
3-trimethylsilyl-1-propanesulfonate, sodium salt; 2,2-Dimethyl-2-silapentane-5-sulfonate sodium salt; DSS sodium salt(trimethylsilyl)-1-propanesulfonate
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| Identifiers | |
3D model (JSmol)
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| Abbreviations | DSS |
| ChemSpider | |
| EC Number |
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PubChem CID
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CompTox Dashboard (EPA)
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| Properties | |
| C6H15NaO3SSi | |
| Molar mass | 218.32 g·mol−1 |
| Appearance | White solid |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sodium trimethylsilylpropanesulfonate (DSS) is the organosilicon compound with the formula (CH3)3SiCH2CH2CH2SO3−Na+. It is the sodium salt of trimethylsilylpropanesulfonic acid. A white, water-soluble solid, it is used as a chemical shift standard for proton NMR spectroscopy of aqueous solutions.[1] The chemical shift, specifically the signal for the trimethylsilyl group, is relatively insensitive to pH.[2]
The proton spectrum of DSS also exhibits resonances at 2.91 ppm (m), 1.75 ppm (m), and 0.63 ppm (m) at an intensity of 22% of the reference resonance at 0 ppm.
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Why tetramethylsilane (TMS) is used as the reference standard in NMR?
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Transcription
Alternatives
Sodium trimethylsilyl propionate (TSP) is a related compound used as an NMR standard. It uses a carboxylic acid instead of the sulfonic acid found in DSS to confer water solubility. As a weak acid, TSP is more sensitive to changes in pH.
4,4-Dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA) has also been proposed as an alternative, to overcome certain drawbacks of DSS.[3]
References
- ^ Harris, Robin K.; Becker, Edwin D.; Cabral De Menezes, Sonia M.; Granger, Pierre; Hoffman, Roy E.; Zilm, Kurt W. (2008). "Further Conventions for NMR Shielding and Chemical Shifts (IUPAC Recommendations 2008)". Pure and Applied Chemistry. 80 (2): 59–84. Bibcode:2008JMagR.191..340.. doi:10.1351/pac200880010059.
- ^ De Marco, Antonio (1977). "pH Dependence of Internal References". Journal of Magnetic Resonance. 26 (3): 527–528. Bibcode:1977JMagR..26..527D. doi:10.1016/0022-2364(77)90104-4.
- ^ Nowick, James S.; Khakshoor, Omid; Hashemzadeh, Mehrnoosh; Brower, Justin O. (2003). "DSA: A New Internal Standard for NMR Studies in Aqueous Solution". Org. Lett. 5 (19): 3511–3513. doi:10.1021/ol035347w. PMID 12967312.
This page was last edited on 20 June 2022, at 08:17