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DPPA3

From Wikipedia, the free encyclopedia

DPPA3

Identifiers

DPPA3, STELLA, developmental pluripotency associated 3, Pgc7

External IDs

OMIM: 608408 HomoloGene: 138483 GeneCards: DPPA3

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.31	Start	7,711,433 bp^[1]
Band	12p13.31	End	7,717,559 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

duodenum

blood

muscle tissue

liver

islet of Langerhans

smooth muscle tissue

respiratory system

lung

n/a

More reference expression data

n/a

Gene ontology
Molecular function	methylated histone binding
Cellular component	male pronucleus cytoplasm nucleus female pronucleus
Biological process	multicellular organism development protection of DNA demethylation of female pronucleus negative regulation of DNA demethylation regulation of genetic imprinting chromatin organization
Sources:Amigo / QuickGO

Species

Human

Mouse


359787


n/a


ENSG00000187569


n/a


Q6W0C5


n/a

RefSeq (mRNA)


NM_199286


n/a

RefSeq (protein)


NP_954980


n/a

Location (UCSC)

Chr 12: 7.71 – 7.72 Mb

n/a

PubMed search

^[2]

n/a

View/Edit Human

Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.^[3]

This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187569 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: DPPA3 developmental pluripotency associated 3".

Further reading

Nakamura T, Arai Y, Umehara H, et al. (2007). "PGC7/Stella protects against DNA demethylation in early embryogenesis". Nat. Cell Biol. 9 (1): 64–71. doi:10.1038/ncb1519. PMID 17143267. S2CID 1947132.
Elliman SJ, Wu I, Kemp DM (2006). "Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin". J. Biol. Chem. 281 (1): 16–9. doi:10.1074/jbc.C500415200. PMID 16291741.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bortvin A, Goodheart M, Liao M, Page DC (2004). "Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice". BMC Dev. Biol. 4: 2. doi:10.1186/1471-213X-4-2. PMC 362866. PMID 15018652.
Clark AT, Rodriguez RT, Bodnar MS, et al. (2004). "Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma". Stem Cells. 22 (2): 169–79. doi:10.1634/stemcells.22-2-169. PMID 14990856. S2CID 38136098.
Bowles J, Teasdale RP, James K, Koopman P (2004). "Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours". Cytogenet. Genome Res. 101 (3–4): 261–5. doi:10.1159/000074346. PMID 14684992. S2CID 7005986.
Payer B, Saitou M, Barton SC, et al. (2004). "Stella is a maternal effect gene required for normal early development in mice". Curr. Biol. 13 (23): 2110–7. doi:10.1016/j.cub.2003.11.026. PMID 14654002. S2CID 2010581.
Sato M, Kimura T, Kurokawa K, et al. (2002). "Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells". Mech. Dev. 113 (1): 91–4. doi:10.1016/S0925-4773(02)00002-3. PMID 11900980. S2CID 12877378.

This page was last edited on 3 December 2023, at 01:50

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