RNA Helicase A

DHX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLM, 3VYX, 3VYY
Identifiers
Aliases	DHX9, DDX9, LKP, NDH2, NDHII, RHA, RNA Helicase A, DEAH-box helicase 9, DExH-box helicase 9
External IDs	OMIM: 603115; MGI: 108177; HomoloGene: 1039; GeneCards: DHX9; OMA:DHX9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q25.3 Start 182,839,347 bp[1] End 182,887,982 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 G3|1 65.37 cM Start 153,331,504 bp[2] End 153,363,406 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence sperm Achilles tendon canal of the cervix cerebellar hemisphere right uterine tube lymph node left lobe of thyroid gland right lobe of thyroid gland tibial nerve Top expressed in primitive streak abdominal wall otic placode maxillary prominence vas deferens saccule ganglionic eminence Paneth cell atrium dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA helicase activity nucleotide binding helicase activity protein binding nucleic acid binding hydrolase activity RNA binding DNA binding single-stranded DNA binding double-stranded RNA binding single-stranded RNA binding nucleoside-triphosphatase activity chromatin DNA binding 3'-5' DNA/RNA helicase activity 3'-5' RNA helicase activity triplex DNA binding nucleoside-triphosphate diphosphatase activity importin-alpha family protein binding single-stranded 3'-5' DNA helicase activity siRNA binding mRNA binding RNA stem-loop binding polysome binding promoter-specific chromatin binding RNA polymerase II complex binding regulatory region RNA binding transcription coregulator activity transcription coactivator activity DNA replication origin binding double-stranded DNA binding DNA helicase activity ATP binding ATPase activity RNA polymerase binding 3'-5' DNA helicase activity RISC complex binding sequence-specific mRNA binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component CRD-mediated mRNA stability complex cytosol centrosome membrane cytoplasmic ribonucleoprotein granule nucleus nucleolus perichromatin fibrils cytoplasm nuclear stress granule nuclear body polysomal ribosome polysome actin cytoskeleton RISC-loading complex nucleoplasm microtubule organizing center cytoskeleton protein-containing complex ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA splicing, via spliceosome RNA processing rhythmic process protein localization to cytoplasmic stress granule osteoblast differentiation positive regulation of type I interferon production RNA secondary structure unwinding positive regulation of DNA repair positive regulation of transcription by RNA polymerase II positive regulation of response to cytokine stimulus cellular response to exogenous dsRNA alternative mRNA splicing, via spliceosome DNA-templated viral transcription positive regulation of viral transcription positive regulation of viral translation positive regulation of cytoplasmic translation regulation of transcription by RNA polymerase II DNA duplex unwinding positive regulation of DNA replication positive regulation of fibroblast proliferation regulation of mRNA processing positive regulation of NF-kappaB transcription factor activity cellular response to tumor necrosis factor positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity regulation of cytoplasmic translation positive regulation of interleukin-18 production G-quadruplex DNA unwinding positive regulation of innate immune response positive regulation of RNA export from nucleus regulation of defense response to virus by host positive regulation of inflammatory response pyroptosis small RNA loading onto RISC positive regulation of polysome binding positive regulation of gene silencing by miRNA immune system process DNA replication transcription, DNA-templated DNA-templated transcription, termination regulation of transcription, DNA-templated mRNA processing regulation of translation transport inflammatory response RNA splicing gene silencing innate immune response mRNA transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1660 13211 Ensembl ENSG00000135829 ENSMUSG00000042699 UniProt Q08211 O70133 RefSeq (mRNA) NM_001357 NM_030588 NM_007842 RefSeq (protein) NP_001348 NP_031868 NP_001392438 Location (UCSC) Chr 1: 182.84 – 182.89 Mb Chr 1: 153.33 – 153.36 Mb PubMed search [3] [4]
Wikidata
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ATP-dependent RNA helicase A (RHA; also known as DHX9, LKP, and NDHI) is an enzyme that in humans is encoded by the DHX9 gene.^[5][6][7]

Function

DEAD/DEAH box helicases are proteins, and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein with RNA helicase activity. It may participate in melting of DNA:RNA hybrids, such as those that occur during transcription, and may play a role in X-linked gene expression. It contains 2 copies of a double-stranded RNA-binding domain, a DEXH core domain and an RGG box. The RNA-binding domains and RGG box influence and regulate RNA helicase activity.^[7] The DHX9 gene is located on the long arm q of chromosome 1.

Interactions

DHX9 has been shown to interact with:

References

Further reading

This page was last edited on 13 May 2024, at 12:14