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Doublecortin domain-containing protein 2 (DCDC2) is a protein that in humans is encoded by the DCDC2gene.[5][6][7]
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Function
This gene encodes a protein with two doublecortin peptide domains. This domain has been demonstrated to bind tubulin and enhance microtubule polymerization.[7]
Clinical significance
Mutations in this gene have been associated with reading disability (RD), also referred to as developmental dyslexia.[7][8] But this is controverse since a recent study proposed that there is a "low likelihood of a direct deletion effect on reading skills."[9]
Changes in the DCDC2 gene are frequently found among dyslexics. Altered alleles often occur among children with reading and writing difficulties. The gene appears to have a strong linkage with the processing of speech information when writing.[10][11][12]
Brkanac Z, Chapman NH, Matsushita MM, et al. (2007). "Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 556–60. doi:10.1002/ajmg.b.30471. PMID17450541. S2CID43864328.
This page was last edited on 3 November 2023, at 01:40