Fumaria officinalis

Fumaria officinalis

Scientific classification
Kingdom:	Plantae
Clade:	Tracheophytes
Clade:	Angiosperms
Clade:	Eudicots
Order:	Ranunculales
Family:	Papaveraceae
Genus:	Fumaria
Species:	F. officinalis
Binomial name
*Fumaria officinalis* L.

Fumaria officinalis, the common fumitory, drug fumitory or earth smoke, is a herbaceous annual flowering plant in the poppy family Papaveraceae. It is the most common species of the genus Fumaria in Western and Central Europe.

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Formerly included in the family of Papaveraceae. Common names: Common Fumitory, Earth smoke Fumaria officinalis is cosmopolitan, native to Europe, including Britain and the Mediterranean, but has been introduced into North America. We find also in eastern Iran, and in some areas of North Africa and temperate areas of Asia. It grows in cultivated fields or plains of dry soil, and can be found in gardens as weed. Is an annual herbaceous plant and hermaphrodite, with life-form as terophytes. Is glabrous, well branched stems, rather diffuse and reaches 50 cm in height. The leaves are pinnatelycompounded, alternated. At the beginning of spring, it forms an inflorescence in terminal clusters of a dozen zygomorphic flowers wich their size is between 7-9 mm. The flowers have the calyx formed by two small sepals, whitish, ovate, with the jagged edge. The corolla comprises four petals together at the apex but free, where the uppermost continues on a spur. The adroecium presents six stamens consolidated by the filaments into two groups, each divided into three anthers. The gynoecium shows two carpels, with a superior ovary. The fruit is a small globose achene, rugged and striated, about 2 mm of size. Is used as an infusion, acting as liver regulator, diuretic and laxative, and topically to the scalp conditions. The overdose should be avoided, because the alkaloids can be cardiotoxic at high doses. No side effects have been reported. In its chemical composition are commonly: fumaric acid, phenolic acid and protopin (a compound of opium). Also have flavonoids, about 20 alkaloids, protoberberines and benzodiazepines. There are medicines wich contains Fumaria officinalis as: Eoldo Digescap Complex, Arkocapsulas Fumaria, Composor19 Depulán. (www.vademecum.es)

Description

It is an herbaceous annual plant that grows weakly erect and scrambling, with stalks about 10–50 cm (3.9–19.7 in) long. It has slender green leaves.^[1] Its pink 7–9 mm (0.28–0.35 in) flowers appear from April to October in the northern hemisphere,^[2] or May to September in the UK.^[1] They are two lipped and spurred, with sepals running a quarter the length of the petals.^[2] The plant commonly has more than 20 and up to 60 flowers per spike.^[3] The fruit is an achene containing one seed. It is approximately globular, slightly wider than high and with an apical notch.^[3] It contains alkaloids, potassium salts, and tannins and is also a source of fumaric acid.^[4]

Taxonomy

It was first formally described by the Swedish botanist Carl Linnaeus in his seminal publication 'Species Plantarum' on page 700, in 1753.^[5]^[6]

There are 2 known subspecies:

Fumaria officinalis subsp. cilicica (Hausskn.) Lidén
Fumaria officinalis subsp. wirtgenii (Koch) Arcang.^[5]

Etymology

The "smoky" or "fumy" origin of its name comes from the translucent color of its flowers, giving them the appearance of smoke or of hanging in smoke, and the slightly gray-blue haze color of its foliage, also resembling smoke coming from the ground, especially after morning dew.^{[citation needed]}

The plant was already called fūmus terrae (smoke of the earth) in the early 13th century, and two thousand years ago, Dioscorides wrote in De Materia Medica (Περὶ ὕλης ἰατρικῆς) and Pliny the Elder in Naturalis Historia that rubbing the eyes with the sap or latex of the plant causes tears, like acrid smoke (fūmus) does to the eyes. Its Greek name is kapnos (καπνός, for smoke) and the name fumewort now applies mostly to the genus Corydalis, especially the similar looking Corydalis solida (formerly Fumaria bulbosa), which was thought to belong to the same genus as fumitory.^[7]

Distribution and habitat

It is native to temperate regions of North Africa, Europe and parts of Western Asia.^[8]

Range

It is found in North Africa, within Macaronesia, Canary Islands, Algeria, Egypt, Libya, Morocco and Tunisia. Within Western Asia it is found in the Caucasus, Cyprus, Iraq, Israel, Lebanon, Siberia, Syria and Turkey. In eastern Europe, it is found within Belarus, Estonia, Latvia, Lithuania and Ukraine. In middle Europe, it is in Austria, Belgium, Germany, Hungary, Netherlands, Poland, Slovakia and Switzerland. In northern Europe, in Denmark, Ireland, Norway, Sweden and United Kingdom. In southeastern Europe, within Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Greece, Italy, Montenegro, North Macedonia, Romania, Serbia and Slovenia. Also in southwestern Europe, it is found in France, Portugal and Spain.^[8] It is common in Australia where it was introduced.^[9]

Herbalism

Usage of this plant as medicine began in Europe in the late Middle Ages, although it was known since antiquity.^[4] In 17th century Europe it was publicised as good for the eyes (due to remarks by Pliny and later Olivier de Serres that rubbing its juice in one's eyes caused excessive tearing).^[4]^[10] The most common traditional uses were as a digestive aid and a diuretic, but various folk traditions throughout Europe ascribed to it a multitude of uses: constipation, cystitis, arteriosclerosis, rheumatism, arthritis, as a blood purifier, for hypoglycaemia, infections,^[4] and possibly to cleanse the kidneys.^[10] In Sicily and perhaps elsewhere it was used to treat skin blemishes, and in Britain into the modern era as an eyewash to treat conjunctivitis.^[4]^[10]^[11]

Since 1963, it has been marketed as a herbal medicine in France.^[4] As of 2011, herbal products made from this plant are legally sold in various forms in Austria, Germany, France and Spain. Products may be legally sold in the British market (it is on the British General Sales List), although no products were sold there as of 2011. In the European Union as a whole, marketing of the plant is not necessarily legal: it has been rejected from the Community List by the Committee on Herbal Medicinal Products due to the lack of toxicology studies. Products in France and Spain are marketed as a digestive (said to work by increasing bile flow), in Austria it is sold for treatment of dyskinesia of the biliary duct, in Germany it is simply sold as an herbal tea.^[4]

There is some evidence from animal models that it modifies abnormal bile flow, although it has no effect on normal choleresis. An antispasmodic effect on the upper digestive tract in vitro and in animal studies is considered sufficiently documented. The efficacy of the herbal products in humans is considered plausible but yet unproven in clinical studies. Numerous clinical studies in its amphocholeretic uses in humans have demonstrated the tolerability and safety of dosages used, but there has only been one small double-blind trial with placebos which was inconclusive regarding efficacy. A larger double-blind trial with placebos investigating and comparing its use in the treatment of pain and distension due to irritable bowel syndrome with Curcuma demonstrated no statistically significant differences between treatment groups (although use of either herb appeared to slightly worsen either distension or pain respectively, compared to placebo use). A number of other potential effects or uses for the plant and its major alkaloid protopine have been researched in vitro or in animal models.^[4]

Howard (1987) warns that fumitory is poisonous and should only be used "under the direction of a medical herbalist",^[10] but in Europe, no safety problems with its use have been recorded as of 2011.^[4] Large doses of protopine in animal models causes excitation and convulsions. Thorough toxicological research on this plant has not been conducted as of 2011. There have been no studies on its safety or effect on pregnant woman, children or elderly.^[4]

Chemical constituents

The plant contains isoquinoline alkaloids protopine and allocryptopine. Both protopine and allocryptopine increased CYP1A1 and CYP1A2 mRNA levels in human hepatocyte cells. The use of products containing protopine and/or allocryptopine may be considered safe in terms of possible induction of CYP1A enzymes.^[12]

References

^ ^a ^b Reader's Digest Field Guide to the Wild Flowers of Britain. Reader's Digest. 1981. p. 37. ISBN 9780276002175.
^ ^a ^b Fitter, Richard; Fitter, Alastair; Blamey, Marjorie (1974). The Wild Flowers of Britain and Northern Europe. London: Collins. p. 78. ISBN 0-00-219057-5.
^ ^a ^b Murphy, R.J. (2009). Fumitories of Britain and Ireland. BSBI Handbbok No. 12. London: Botanical Society of Britain and Ireland. ISBN 9780901158406.
^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j Ioanna Chinou (13 September 2011). Assessment report on Fumaria officinalis L., herba (PDF) (Report). European Medicines Agency, Committee on Herbal Medicinal Products (HMPC). EMA/HMPC/576232/2010. Retrieved 5 May 2019.
^ ^a ^b "Fumaria officinalis L. is an accepted name". theplantlist.org. 23 March 2012. Retrieved 5 November 2017.
^ "Papaveraceae Fumaria officinalis L." ipni.org. Retrieved 5 November 2017.
^ The Names of Plants, Fourth Edition, Gledhill, D. (1985–2008). The Names of Plants. United Kingdom: Cambridge University Press. p. 443. ISBN 978-0-521-86645-3.
^ ^a ^b "Taxon: Fumaria officinalis L." ars-grin.gov. Retrieved 5 November 2017.
^ https://bie.ala.org.au/species/https://id.biodiversity.org.au/node/apni/2904208 Atlas Of Living Australia
^ ^a ^b ^c ^d Howard, Michael. Traditional Folk Remedies (century, 1987). pp142-3.
^ Amenta R, Camarda L, Di Stefano V, Lentini F, Venza F (2000). "Traditional medicine as a source of new therapeutic agents against psoriasis". Fitoterapia. 71 Suppl 1: S13–20. doi:10.1016/s0367-326x(00)00172-6. PMID 10930708.
^ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). "Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR". Toxicology Letters. 203 (2): 135–141. doi:10.1016/j.toxlet.2011.03.015. PMID 21419197.