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| Trade names | Coldrin, Gentos, Pectolitan, Ulo, Ulone |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Oral |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.011.219 |
| Chemical and physical data | |
| Formula | C17H20ClNO |
| Molar mass | 289.80 g·mol−1 |
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Clofedanol (INN) or chlophedianol (BAN), sold under the brand name Ninjacof among others, is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic, antispasmodic, and antihistamine properties,[1] and may have anticholinergic effects at high doses.[2]
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Transcription
Side effects
Adverse effects may include irritability, drowsiness, nightmares, vertigo, nausea or vomiting, visual disturbances or hallucinations, and urticaria. There are potential interactions with other anticholinergics, CNS depressants, and alcohol.[3]
Pharmacology
Unlike many other antitussive drugs such as dextromethorphan, it binds poorly to the sigma-1 receptor.[4]
Society and culture
Chlophedianol was approved for OTC status in 1987 by the FDA OTC monograph process[5] and its safety and efficacy data are limited. It was formerly sold over-the-counter in the United States under the trade name Ulo, as a syrup with a dosage of 25 mg/5 mL.[6] It is now marketed under the brand name of Ninjacof in the U.S.
It is marketed in Canada under the trade name Ulone. GM Pharmaceuticals owns the patents to 113 combinations with Chlophedianol and was the first company to launch the cough suppressant in the United States.[7]
It is sold in Japan as an over-the-counter drug under the name Coldrin.[8] It has been marketed in Germany as Pectolitan and in Spain as Gentos.[9]
See also
References
- ^ Martín AV (2004). "Tratamiento sintomático de la tos y del resfriado común". Farmacología clínica y terapéutica médica. McGraw-Hill/Interamericana. p. 260. ISBN 9788448604271.
- ^ "Clofedanol" (in French). BIAM. 1998-07-24. Retrieved 2007-04-15.
- ^ Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 29. ISBN 0-8103-7177-4.
- ^ Klein M, Musacchio JM (October 10, 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–156. doi:10.1007/BF00711241. PMID 3044591. S2CID 33844132.
- ^ "Department of Health and Human Services. Food and Drug Administration. 21 CFR Parts 310, 341, and 369. Docket No. 76N-052T. Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; final monograph for OTC antitussive drug products. Federal Register 1987;52(155):30042-57" (PDF). FDA.gov. 1987-08-12.
- ^ Approved Drug Products with Therapeutic Equivalence Evaluations, March 2020 Edition (Report). Food and Drug Administration. March 20, 2020. Retrieved April 7, 2021.
- ^ "How Odes Mitchell Built a Pharmaceutical Empire". D Magazine. 9 June 2017. Retrieved 2020-11-25.
- ^ "クロフェダノール:コルドリン" [Clofedanol: Coldrin]. Medicine 110 (in Japanese). Retrieved March 22, 2021.
- ^ Schlesser JL (1991). Drugs Available Abroad, 1st Edition. Derwent Publications Ltd. p. 29. ISBN 0-8103-7177-4.
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This page was last edited on 5 January 2024, at 06:08