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Citrobacter koseri

From Wikipedia, the free encyclopedia

Citrobacter koseri
Scientific classification Edit this classification
Domain: Bacteria
Phylum: Pseudomonadota
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species:
C. koseri
Binomial name
Citrobacter koseri
Frederiksen 1970[1]
Synonyms
  • Citrobacter diversus
    (Burkey 1928)
    Werkman & Gillen 1932
    [1]

Citrobacter koseri, formerly known as Citrobacter diversus, is a Gram-negative non-spore forming, rod-shaped bacterium. It is a facultative anaerobe capable of aerobic respiration. It is motile via peritrichous flagella.[2] It is a member of the family of Enterobacteriaceae. The members of this family are part of the normal flora and commonly found in the digestive tracts of humans and animals.[1] C. koseri may act as an opportunistic pathogen in individuals who are immunocompromised.[3]

It rarely is community-acquired and mainly occurs as hospital-acquired infections. Infections caused by C. koseri can lead to various symptoms, including fever, chills, diarrhea, and abdominal pain. In severe cases, the bacterium can cause sepsis, meningitis, or brain abscesses. Brain abscesses have a high rate of mortality and complications, particularly in neonates. The transmission of C. koseri could be vertical from mother to fetus, and other sources can be horizontal by asymptomatic nursery staff.[4]

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Transcription

Signs and symptoms

Neonates infected with C. koseri usually present with sepsis, meningitis, seizures, apnea, and a bulging fontanelle. No evidence of a stiff neck or high-grade fever is present.[5]

Complications

Occasionally, it causes meningitis, but it can cause sepsis and ventriculitis.[5]

Arterial and venous infarctions are possible because of the bacterial infiltration along the main vessel; exudates within the ventricles and ventriculitis may obstruct the ventricular foramina and result in multicystic hydrocephalus with consequent long-lasting shunting difficulties and necrotizing meningoencephalitis with pneumocephalus has been reported.[5]

Pathogenicity

The pathogenic mechanism is poorly understood. C. koseri may uniquely penetrate, survive, and replicate into vascular endothelial cells and macrophages. Furthermore, it survives in phagolysosomal fusion and replicates within macrophages, which may contribute to the establishment of chronic abscesses.[5][6]

Diagnosis

Medical imaging

Early and massive tissue necrosis is a specific feature of C. koseri brain infection. The early stage of the disease predominates in the white matter, causing cerebritis; the later stage is marked with necrotic cavities in multiple locations. The cavities are initially square and not tense, but when pus forms and collects in these cavities, they tend to become more rounded; a persisting cavity leads to septated ventriculitis that may result in multicystic hydrocephalus.[5]

Early cerebritis is seen, and multiple large cavities can be seen in the late stage of the disease; abscesses formation, contraction of the cavities, and hydrocephalus due to ventriculitis are observed in the late follow-up.[5][6]

Pathology

Macroscopic findings include purulent exudates, opaque leptomeninges (thinning of meninges), pus, and ventriculitis/ ependymitis.

Microbiology

In samples collected from cerebrospinal fluid, C. koseri grows well on any ordinary medium; they produce unpigmented, colorless mucoid colonies. If incubated for 24 hours in other media such as indole, citrate, and adonitol, C. koseri will be positive, hydrogen sulfide negative in Kligers’ iron agar, and negative results in lactose, salicin, and sucrose broth as well.[5][7]

Histology

Citrobacter koseri may be identified in the walls of congested vessels; the presence of the cavities resulting from the infection does not develop a well-formed fibrotic wall.[5]

Differential diagnosis

The differential diagnosis of C. koseri brain abscesses can be confused with other related diseases, so diagnostic imaging is essential to confirm this bacterium. The significant feature of C. koseri is the necrotic cavity which cannot be misidentified as an earlier ischemic or hemorrhagic insult or other mass lesions; congential/neonatal tumors are uncommon (choroid plexus papillomas, craniopharyngiomas, teratomas); even when they present, they are different from the inflammatory ring of cerebral infection. Early cerebritis should not be mistaken for normal, immature white matter, nor cicatricial leukomalacia.[5][6]

Treatment

A broad spectrum cephalosporin and meropenem are often used because of the good penetration into the central nervous system. If the response to the antibiotic is poor, the surgical aspiration of the collected pus reduces the mass effect and enhances the efficacy of the antibiotics.[5][7][8]

Prognosis

The prognosis of the C. koseri infection is 20 to 30% of neonates die, and 75% of survivors have significant neurologic damage such as complex hydrocephalus, neurologic deficits, mental delay, and epilepsy.[5]

Control

The most effective way to reduce transmission of organisms is regular handwashing.[5]

References

  1. ^ a b "Species Citrobacter koseri". LPSN. Retrieved 21 April 2023.
  2. ^ Ong CL, Beatson SA, Totsika M, Forestier C, McEwan AG, Schembri MA (2010). "Molecular analysis of type 3 fimbrial genes from Escherichia coli, Klebsiella and Citrobacter species". BMC Microbiol. 10: 183. doi:10.1186/1471-2180-10-183. PMC 2900259. PMID 20576143.
  3. ^ Pennington, Kelly; Van Zyl, Martin; Escalante, Patricio (6 October 2016). "Citrobacter koseri Pneumonia as Initial Presentation of Underlying Pulmonary Adenocarcinoma". Clinical Medicine Insights: Case Reports. 9: 87–89. doi:10.4137/CCRep.S40616. ISSN 1179-5476. PMC 5054941. PMID 27746678.
  4. ^ Greenwood, David; Slack, Richard C. B.; Peutherer, John F.; Barer, Michael R. (2007). Medical Microbiology: A Guide to Microbial Infections: Pathogenesis, Immunity, Laboratory Diagnosis and Control (17th ed.). Elsevier. pp. 1264–6. ISBN 978-0-7020-4009-2.
  5. ^ a b c d e f g h i j k l Babyn, Paul S. (2011). "Section I: Neuroradiology: Case 3". Teaching Atlas of Pediatric Imaging. Thieme. pp. 44–7. ISBN 978-1-60406-494-0.
  6. ^ a b c Doran TI (1999). "The role of Citrobacter in clinical disease of children: review". Clin. Infect. Dis. 28 (2): 384–94. doi:10.1086/515106. PMID 10064257.
  7. ^ a b Feferbaum R, Diniz EM, Valente M, Giolo CR, Vieira RA, Galvani AL, Ceccon ME, Araujo MC, Krebs VL, Vaz FA (2000). "Brain abscess by Citrobacter diversus in infancy: case report". Arq Neuropsiquiatr. 58 (3A): 736–40. doi:10.1590/s0004-282x2000000400023. PMID 10973119.
  8. ^ McPherson C, Gal P, Ransom JL (2008). "Treatment of Citrobacter koseri infection with ciprofloxacin and cefotaxime in a preterm infant". Ann Pharmacother. 42 (7): 1134–8. doi:10.1345/aph.1L008. PMID 18577764. S2CID 12607380.

External links

This page was last edited on 3 December 2023, at 03:40
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