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Cannabis (drug)

From Wikipedia, the free encyclopedia

Cannabis
Cannabis Plant.jpg
A flowering cannabis plant
Product name Cannabis
Pronunciation
Source plant(s) Cannabis sativa, Cannabis sativa forma indica, Cannabis ruderalis
Part(s) of plant Flower
Geographic origin Central and South Asia[1]
Active ingredients Tetrahydrocannabinol, cannabidiol, cannabinol, tetrahydrocannabivarin
Main producers Afghanistan,[2] Canada,[3] China, Colombia,[4] India,[2] Jamaica,[2] Lebanon,[5] Mexico,[6] Morocco,[2] Netherlands, Pakistan, Paraguay,[6] Spain,[2] Thailand, Turkey, United States[2]
Legal status
  • AU: S9 (Prohibited)
  • CA: Schedule II (legal for medical use)
  • DE: Medical cannabis from state-controlled production: Anlage III, other cannabis: I
  • UK: Class B
  • US: Schedule I (legal in 9 states for recreational use)
  • UN: Narcotic Schedule I

Cannabis, also known as marijuana among other names,[n 1] is a psychoactive drug from the Cannabis plant intended for medical or recreational use.[16][17][18] The main psychoactive part of cannabis is tetrahydrocannabinol (THC); one of 483 known compounds in the plant,[19] including at least 65 other cannabinoids.[20] Cannabis can be used by smoking, vaporizing, within food, or as an extract.[21]

Cannabis is often used for its mental and physical effects, such as a "high" or "stoned" feeling, a general change in perception, euphoria (heightened mood), and an increase in appetite.[21][22] Onset of effects is within minutes when smoked, and about 30 to 60 minutes when cooked and eaten.[21][23] They last for between two and six hours.[23] Short-term side effects may include a decrease in short-term memory, dry mouth, impaired motor skills, red eyes, and feelings of paranoia or anxiety.[21][24][25] Long-term side effects may include addiction, decreased mental ability in those who started as teenagers, and behavioral problems in children whose mothers used cannabis during pregnancy.[21] Studies have found a strong relation between cannabis use and the risk of psychosis,[26] though the cause-and-effect relationship is debated.[27]

Cannabis is mostly used recreationally or as a medicinal drug, although it may also be used for religious or spiritual purposes. In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).[28] In 2015, 43% of Americans had ever used cannabis, which increased to 51% in 2016.[29] About 12% have used it in the past year, and 7.3% have used it in the past month.[30] This makes it the most commonly used illegal drug both in the world and the United States.[21][28]

The earliest recorded uses date from the 3rd millennium BC.[31] Since the early 20th century, cannabis has been subject to legal restrictions. The possession, use, and sale of cannabis is illegal in most countries of the world.[32][33] Medical cannabis refers to the physician-recommended use of cannabis, which is taking place in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 23 U.S. states.[34] Cannabis use started to become popular in the U.S. in the 1970s.[35] Support for legalization has increased in the United States and several U.S. states have legalized recreational or medical use.[36]

Uses

Medical

 Main short-term physical effects of cannabis
Main short-term physical effects of cannabis

Medical cannabis, or medical marijuana, can refer to the use of cannabis and its cannabinoids to treat disease or improve symptoms; however, there is no single agreed-upon definition.[37][38] The rigorous scientific study of cannabis as a medicine has been hampered by production restrictions and other federal regulations.[39] There is limited evidence suggesting cannabis can be used to reduce nausea and vomiting during chemotherapy, to improve appetite in people with HIV/AIDS, and to treat chronic pain and muscle spasms.[40][41][42] Its use for other medical applications is insufficient for conclusions about safety or efficacy.

Short-term use increases the risk of both minor and major adverse effects.[41] Common side effects include dizziness, feeling tired and vomiting.[41] Long-term effects of cannabis are not clear.[41] Concerns include memory and cognition problems, risk of addiction, schizophrenia in young people, and the risk of children taking it by accident.[40]

Recreational

 A woman smoking a marijuana "joint".
A woman smoking a marijuana "joint".

Cannabis has psychoactive and physiological effects when consumed.[43] The immediate desired effects from consuming cannabis include relaxation and euphoria (the "high" or "stoned" feeling), a general alteration of conscious perception, increased awareness of sensation, increased libido[44] and distortions in the perception of time and space. At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes. In some cases, cannabis can lead to dissociative states such as depersonalization[45][46] and derealization.[47]

Some immediate undesired side effects include a decrease in short-term memory, dry mouth, impaired motor skills and reddening of the eyes.[48] Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory,[49][50] psychomotor coordination, and concentration. Some users may experience an episode of acute psychosis, which usually abates after six hours, but in rare instances, heavy users may find the symptoms continuing for many days.[51] A reduced quality of life is associated with heavy cannabis use, although the relationship is inconsistent and weaker than for tobacco and other substances.[52] It is unclear, however, if the relationship is cause and effect.[52]

Spiritual

 Process of making bhang in a Sikh village in Punjab, India. On the festival of colors called Holi, it is a customary addition to some intoxicating drinks.[53]
Process of making bhang in a Sikh village in Punjab, India. On the festival of colors called Holi, it is a customary addition to some intoxicating drinks.[53]

Cannabis has held sacred status in several religions. It has been used in an entheogenic context – a chemical substance used in a religious, shamanic, or spiritual context[54] - in India and Nepal since the Vedic period dating back to approximately 1500 BCE, but perhaps as far back as 2000 BCE. There are several references in Greek mythology to a powerful drug that eliminated anguish and sorrow. Herodotus wrote about early ceremonial practices by the Scythians, thought to have occurred from the 5th to 2nd century BCE. In modern culture the spiritual use of cannabis has been spread by the disciples of the Rastafari movement who use cannabis as a sacrament and as an aid to meditation. The earliest known reports regarding the sacred status of cannabis in India and Nepal come from the Atharva Veda estimated to have been written sometime around 2000–1400 BCE.[55]

Available forms

 A joint prior to rolling, with a paper handmade filter on the left
A joint prior to rolling, with a paper handmade filter on the left

Cannabis is consumed in many different ways:[56]

  • smoking, which typically involves burning and inhaling vaporized cannabinoids ("smoke") from small pipes, bongs (portable versions of hookahs with a water chamber), paper-wrapped joints or tobacco-leaf-wrapped blunts, and other items.[57]
  • vaporizer, which heats any form of cannabis to 165–190 °C (329–374 °F),[58] causing the active ingredients to evaporate into a vapor without burning the plant material (the boiling point of THC is 157 °C (315 °F) at 760 mmHg pressure).[59]
  • cannabis tea, which contains relatively small concentrations of THC because THC is an oil (lipophilic) and is only slightly water-soluble (with a solubility of 2.8 mg per liter).[60] Cannabis tea is made by first adding a saturated fat to hot water (e.g. cream or any milk except skim) with a small amount of cannabis.[61]
  • edibles, where cannabis is added as an ingredient to one of a variety of foods, including butter and baked goods. In India it is commonly made into a beverage, bhang.

Adverse effects

 Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Cannabis was ranked 11th in dependence, 17th in physical harm, and 10th in social harm.[62]
Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Cannabis was ranked 11th in dependence, 17th in physical harm, and 10th in social harm.[62]

According to the United States Department of Health and Human Services, there were 455,000 emergency room visits associated with cannabis use in 2011. These statistics include visits in which the patient was treated for a condition induced by or related to recent cannabis use. The drug use must be "implicated" in the emergency department visit, but does not need to be the direct cause of the visit. Most of the illicit drug emergency room visits involved multiple drugs.[63] In 129,000 cases, cannabis was the only implicated drug.[64][65]

Heavy, long term exposure to marijuana may have biologically-based physical, mental, behavioral and social health consequences and may be "associated with diseases of the liver (particularly with co-existing hepatitis C), lungs, heart, and vasculature".[66] It is recommended that cannabis use be stopped before and during pregnancy as it can result in negative outcomes for both the mother and baby.[67][68] However, maternal use of marijuana during pregnancy does not appear to be associated with low birth weight or early delivery after controlling for tobacco use and other confounding factors.[69] A 2014 review found that while cannabis use may be less harmful than alcohol use, the recommendation to substitute it for problematic drinking is premature without further study.[70] Other side effects include cannabinoid hyperemesis syndrome.[71]

Acute

Acute effects may include anxiety and panic, impaired attention, and memory (while intoxicated), an increased risk of psychotic symptoms, and possibly an increased risk of accidents if a person drives a motor vehicle while intoxicated.[72] Short-term cannabis intoxication can hinder the mental processes of organizing and collecting thoughts. This condition is known as temporal disintegration.[73] Psychotic episodes are well-documented and typically resolve within minutes or hours. There have been few reports of symptoms lasting longer.[74][75] Studies have found that cannabis use during adolescence is associated with impairments in memory that persist beyond short-term intoxication.[76]

Lungs

A limited number of studies have examined the effects of cannabis smoking on the respiratory system.[77] Chronic heavy marijuana smoking is associated with coughing, production of sputum, wheezing, and other symptoms of chronic bronchitis.[72] The available evidence does not support a causal relationship between cannabis use and chronic obstructive pulmonary disease.[78] Short-term use of cannabis is associated with bronchodilation.[79]

Cancer

Cannabis smoke contains thousands of organic and inorganic chemical compounds. This tar is chemically similar to that found in tobacco smoke,[80] and over fifty known carcinogens have been identified in cannabis smoke,[81] including; nitrosamines, reactive aldehydes, and polycylic hydrocarbons, including benz[a]pyrene.[82] Cannabis smoke is also inhaled more deeply than is tobacco smoke.[83] As of 2015, there is no consensus regarding whether cannabis smoking is associated with an increased risk of cancer.[84] Light and moderate use of cannabis is not believed to increase risk of lung or upper airway cancer. Evidence for causing these cancers is mixed concerning heavy, long-term use. In general there are far lower risks of pulmonary complications for regular cannabis smokers when compared with those of tobacco.[85] A 2015 review found an association between cannabis use and the development of testicular germ cell tumors (TGCTs), particularly non-seminoma TGCTs.[86] A 2015 analysis of six studies found little evidence that long-term or regular cannabis smoking was associated with lung cancer risk, though it could not rule out whether an association with heavy smoking exists.[87] Another 2015 meta-analysis found no association between lifetime cannabis use and risk of head or neck cancer.[88] Combustion products are not present when using a vaporizer, consuming THC in pill form, or consuming cannabis foods.[citation needed]

Cardiovascular

There is concern that cannabis may contribute to cardiovascular disease.[89] As of 2018 evidence of an association is unclear.[90]

Cannabis is believed to be an aggravating factor in rare cases of arteritis, a serious condition that in some cases leads to amputation. Because 97% of case-reports also smoked tobacco, a formal association with cannabis could not be made. If cannabis arteritis turns out to be a distinct clinical entity, it might be the consequence of vasoconstrictor activity observed from delta-8-THC and delta-9-THC.[91] Other serious cardiovascular events including myocardial infarction, stroke,[92] sudden cardiac death, and cardiomyopathy have been reported to be temporally associated with cannabis use. Research in these events is complicated because cannabis is often used in conjunction with tobacco, and drugs such as alcohol and cocaine.[93] These putative effects can be taken in context of a wide range of cardiovascular phenomena regulated by the endocannabinoid system and an overall role of cannabis in causing decreased peripheral resistance and increased cardiac output, which potentially could pose a threat to those with cardiovascular disease.[94] There is some evidence from case reports that cannabis use may provoke fatal cardiovascular events in young people who have not been diagnosed with cardiovascular disease.[95] Smoking cannabis has also been shown to increase the risk of myocardial infarction by 4.8 times for the 60 minutes after consumption.[96]

Neurological

Anatomy and brain chemistry

Cannabis use is associated with neuroanatomic alterations in brain regions rich in cannabinoid receptors, such as the hippocampus, prefrontal cortex, amygdala, and cerebellum. The same review found that greater dose of marijuana and earlier age at onset of use were also associated with such alterations.[97][98] It is unclear, however, whether these alterations are caused by marijuana use or were present before such use.[99] A 2010 review found resting blood flow to be lower globally and in prefrontal areas of the brain in cannabis users, when compared to non-users. It was also shown that giving THC or cannabis correlated with increased bloodflow in these areas, and facilitated activation of the anterior cingulate cortex and frontal cortex when participants were presented with assignments demanding use of cognitive capacity.[100] Both reviews noted that some of the studies that they examined had methodological limitations, for example small sample sizes or not distinguishing adequately between cannabis and alcohol consumption.[98][100] Cannabis users appear to have smaller hippocampi than nonusers; this finding is based on a series of small studies with inconsistent designs, so it is uncertain.[101] A 2016 meta-analysis found that regular cannabis users tended to have cue reactivity, the intensity of which ranged from moderate to very high.[102]

There is limited evidence that chronic cannabis use can reduce levels of glutamate metabolites in the human brain.[103]

Function

A 2012 meta-analysis found that the effects of cannabis use on neurocognitive functions were "limited to the first 25 days of abstinence" and that there was no evidence that such use had long-lasting effects,[104] while a 2011 review found that cannabis use impaired cognitive functions on several levels, ranging from basic coordination to executive function tasks.[105]

Psychiatric

Epidemiological studies have found a strong correlation between cannabis use and the risk of psychosis, and found the risk is higher with strains higher in THC.[26] However, not all researchers consider this association to reflect a cause-and-effect relationship between cannabis use and psychosis.[27]

It is not clear whether cannabis use affects the rate of suicide.[106][107] It may increase the risk of depression, but further research is needed in this area.[108]

Chronic use

Effects of chronic use in young adulthood include higher levels of substance use disorders, mental health and behavior problems, as well as lower levels of educational and employment outcomes.[109] There is little evidence that cognitive impairments persist in adult abstinent cannabis users.[110] Compared to non-smokers, people who smoked cannabis regularly in adolescence exhibit reduced connectivity in specific brain regions associated with memory, learning, alertness, and executive function.[65] A study has suggested that sustained heavy, daily, adolescent onset cannabis use over decades is associated with a decline in IQ by age 38. No effects were found in those who initiated cannabis use later, or in those who ceased use earlier in adulthood.[95]

Tolerance and withdrawal

Cannabis usually causes no tolerance or withdrawal symptoms except in heavy users. In a survey of heavy users, 42.4% experienced withdrawal symptoms when they tried to quit marijuana, such as craving, irritability, boredom, anxiety and sleep disturbances.[111] About 9% of those who experiment with marijuana eventually become dependent. The rate goes up to 1 in 6 among those who begin use as adolescents, and one-quarter to one-half of those who use it daily according to a NIDA review.[65] A 2013 review estimates daily use is associated with a 10-20% rate of dependence.[40] The highest risk of cannabis dependence is found in those with a history of poor academic achievement, deviant behavior in childhood and adolescence, rebelliousness, poor parental relationships, or a parental history of drug and alcohol problems.[112] Cannabis withdrawal is less severe than withdrawal from alcohol.[113]

Motor vehicle crashes

Marijuana is the most common illegal drug reported in motor vehicle accidents.[114] A 2012 meta-analysis found that cannabis use was associated with an increased risk of being involved in a motor vehicle crash.[115] A 2016 review also found a statistically significant increase in crash risk associated with marijuana use, but noted that this risk was "of low to medium magnitude."[116] The increase in risk of motor vehicle crash for cannabis use is between 2 and 3 times relative to baseline, whereas that for comparable doses of alcohol is between 6 and 15 times.[95]

Overdose

THC, the principal psychoactive constituent of the cannabis plant, has low toxicity. The dose of THC needed to kill 50% of tested rodents is extremely high. Cannabis has not been reported to cause fatal overdose in humans.[106]

Pharmacology

Mechanism of action

The high lipid-solubility of cannabinoids results in their persisting in the body for long periods of time.[117] Even after a single administration of THC, detectable levels of THC can be found in the body for weeks or longer (depending on the amount administered and the sensitivity of the assessment method).[117] A number of investigators have suggested that this is an important factor in marijuana's effects, perhaps because cannabinoids may accumulate in the body, particularly in the lipid membranes of neurons.[118]

Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[119] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[120] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[121] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[122]

Via CB1 receptor activation, THC indirectly increases dopamine release and produces psychotropic effects.[123] Cannabidiol (CBD) also acts as an allosteric modulator of the μ- and δ-opioid receptors.[124] THC also potentiates the effects of the glycine receptors.[125] It is unknown if or how these actions contribute to the effects of cannabis.[citation needed]

Chemistry

Detection in body fluids

THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense.[126] The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[127] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites.[128] Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC.[126] Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[126]

The Duquenois–Levine test is commonly used as a screening test in the field, but it cannot definitively confirm the presence of cannabis, as a large range of substances have been shown to give false positives.[citation needed] Despite this, it is common in the United States for prosecutors to seek plea bargains on the basis of positive D–L tests, claiming them to be conclusive, or even to seek conviction without the use of gas chromatography confirmation, which can only be done in the lab.[129] In 2011, researchers at John Jay College of Criminal Justice reported that dietary zinc supplements can mask the presence of THC and other drugs in urine.[130] However, a 2013 study conducted by researchers at the University of Utah School of Medicine refute the possibility of self-administered zinc producing false-negative urine drug tests.[131]

Varieties and strains

 Types of cannabis
Types of cannabis

CBD is a 5-HT1A receptor agonist, which may also contribute to an anxiolytic effect.[132] This likely means the high concentrations of CBD found in Cannabis indica mitigate the anxiogenic effect of THC significantly.[132] The effects of sativa are well known for their cerebral high, hence its daytime use as medical cannabis, while indica is well known for its sedative effects and preferred night time use as medical cannabis.[132]

Psychoactive ingredients

According to the United Nations Office on Drugs and Crime (UNODC), "the amount of THC present in a cannabis sample is generally used as a measure of cannabis potency."[133] The three main forms of cannabis products are the flower, resin (hashish), and oil (hash oil). The UNODC states that cannabis often contains 5% THC content, resin "can contain up to 20% THC content", and that "Cannabis oil may contain more than 60% THC content."[133]

A 2012 review found that the THC content in marijuana had increased worldwide from 1970 to 2009.[134] It is unclear, however, whether the increase in THC content has caused people to consume more THC or if users adjust based on the potency of the cannabis. It is likely that the higher THC content allows people to ingest less tar. At the same time, CBD levels in seized samples have lowered, in part because of the desire to produce higher THC levels and because more illegal growers cultivate indoors using artificial lights. This helps avoid detection but reduces the CBD production of the plant.[135]

Australia's National Cannabis Prevention and Information Centre (NCPIC) states that the buds (flowers) of the female cannabis plant contain the highest concentration of THC, followed by the leaves. The stalks and seeds have "much lower THC levels".[136] The UN states that leaves can contain ten times less THC than the buds, and the stalks one hundred times less THC.[133]

After revisions to cannabis scheduling in the UK, the government moved cannabis back from a class C to a class B drug. A purported reason was the appearance of high potency cannabis. They believe skunk accounts for between 70 and 80% of samples seized by police[137] (despite the fact that skunk can sometimes be incorrectly mistaken for all types of herbal cannabis).[138][139] Extracts such as hashish and hash oil typically contain more THC than high potency cannabis flowers.[140]

Preparations

Marijuana

Marijuana or marihuana (herbal cannabis),[141] consists of the dried flowers and subtending leaves and stems of the female Cannabis plant.[142][143][144][145] This is the most widely consumed form,[145] containing 3% to 20% THC,[146] with reports of up-to 33% THC.[147] This is the stock material from which all other preparations are derived. Although herbal cannabis and industrial hemp derive from the same species and contain the psychoactive component (THC), they are distinct strains with unique biochemical compositions and uses. Hemp has lower concentrations of THC and higher concentrations of CBD, which decreases the psychoactive effects[148][149]

Kief

Kief is a powder, rich in trichomes,[150] which can be sifted from the leaves and flowers of cannabis plants and either consumed in powder form or compressed to produce cakes of hashish.[151] The word "kif" derives from colloquial Arabic كيف kēf/kīf, meaning pleasure.[152]

Hashish

Hashish (also spelled hasheesh, hashisha, or simply hash) is a concentrated resin cake or ball produced from pressed kief, the detached trichomes and fine material that falls off cannabis flowers and leaves.[153] or from scraping the resin from the surface of the plants and rolling it into balls. It varies in color from black to golden brown depending upon purity and variety of cultivar it was obtained from.[154] It can be consumed orally or smoked, and is also vaporised, or 'vaped'.[155] The term "rosin hash" refers to a high quality solventless product obtained through heat and pressure.[156]

Tincture

Cannabinoids can be extracted from cannabis plant matter using high-proof spirits (often grain alcohol) to create a tincture, often referred to as "green dragon".[157] Nabiximols is a branded product name from a tincture manufacturing pharmaceutical company.[158]

Hash oil

Hash oil is a resinous matrix of cannabinoids obtained from the Cannabis plant by solvent extraction,[159] formed into a hardened or viscous mass.[160] Hash oil can be the most potent of the main cannabis products because of its high level of psychoactive compound per its volume, which can vary depending on the plant's mix of essential oils and psychoactive compounds.[161] Butane and supercritical carbon dioxide hash oil have become popular in recent years.[162]

Infusions

There are many varieties of cannabis infusions owing to the variety of non-volatile solvents used.[163] The plant material is mixed with the solvent and then pressed and filtered to express the oils of the plant into the solvent. Examples of solvents used in this process are cocoa butter, dairy butter, cooking oil, glycerine, and skin moisturizers. Depending on the solvent, these may be used in cannabis foods or applied topically.[164]

Medical use

Medical marijuana refers to the use of the Cannabis plant as a physician-recommended herbal therapy as well as synthetic[165] THC and cannabinoids. So far, the medical use of cannabis is legal only in a limited number of territories, including Canada, Belgium, Australia, the Netherlands, Spain, and many U.S. states. This usage generally requires a prescription, and distribution is usually done within a framework defined by local laws. There is evidence supporting the use of cannabis or its derivatives in the treatment of chemotherapy-induced nausea and vomiting, neuropathic pain, and multiple sclerosis. Lower levels of evidence support its use for AIDS wasting syndrome, epilepsy, rheumatoid arthritis, and glaucoma.[65]

History

 Cannabis sativa from Vienna Dioscurides, AD 512
Cannabis sativa from Vienna Dioscurides, AD 512

Cannabis is indigenous to Central and South Asia,[166] and its use for fabric and rope dates back to the Neolithic age in China and Japan.[167][168] It is unclear when cannabis first became known for its psychoactive properties; some scholars suggest that the ancient Indian drug soma, mentioned in the Vedas, was cannabis, although this theory is disputed.[169]

Cannabis was also known to the ancient Assyrians, who discovered its psychoactive properties through the Aryans.[170] Using it in some religious ceremonies, they called it qunubu (meaning "way to produce smoke"), a probable origin of the modern word "cannabis".[171] The Aryans also introduced cannabis to the Scythians, Thracians and Dacians, whose shamans (the kapnobatai—"those who walk on smoke/clouds") burned cannabis flowers to induce trance.[172]

Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.[173] It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars.[174] Smoking pipes uncovered in Ethiopia and carbon-dated to around c. AD 1320 were found to have traces of cannabis.[175]

Following an 1836–1840 travel in North Africa and the Middle East, French physician Jacques-Joseph Moreau wrote on the psychological effects of cannabis use; Moreau was a member of Paris' Club des Hashischins (founded in 1844).[citation needed] In 1842, Irish physician William Brooke O'Shaughnessy, who had studied the drug while working as a medical officer in Bengal with the East India company, brought a quantity of cannabis with him on his return to Britain, provoking renewed interest in the West.[176] Examples of classic literature of the period featuring cannabis include Les paradis artificiels (1860) by Charles Baudelaire and The Hasheesh Eater (1857) by Fitz Hugh Ludlow.

 Cannabis indica fluid extract, American Druggists Syndicate, pre-1937
Cannabis indica fluid extract, American Druggists Syndicate, pre-1937

Cannabis was criminalized in various countries beginning in the 19th century. The British colonies of Mauritius banned cannabis in 1840 over concerns on its effect on Indian indentured workers;[177] the same occurred in British Singapore in 1870.[178] In the United States, the first restrictions on sale of cannabis came in 1906 (in District of Columbia).[179] It was outlawed in Jamaica (then a British colony) in 1913, in South Africa in 1922, and in the United Kingdom and New Zealand in the 1920s.[180] Canada criminalized cannabis in The Opium and Narcotic Drug Act, 1923,[181] before any reports of the use of the drug in Canada.

In 1925 a compromise was made at an international conference in The Hague about the International Opium Convention that banned exportation of "Indian hemp" to countries that had prohibited its use, and requiring importing countries to issue certificates approving the importation and stating that the shipment was required "exclusively for medical or scientific purposes". It also required parties to "exercise an effective control of such a nature as to prevent the illicit international traffic in Indian hemp and especially in the resin".[182][183] In the United States in 1937, the Marihuana Tax Act was passed,[184] and prohibited the production of hemp in addition to cannabis.

In 1972, the Dutch government divided drugs into more- and less-dangerous categories, with cannabis being in the lesser category. Accordingly, possession of 30 grams or less was made a misdemeanor.[185] Cannabis has been available for recreational use in coffee shops since 1976.[186] Cannabis products are only sold openly in certain local "coffeeshops" and possession of up to 5 grams for personal use is decriminalised, however: the police may still confiscate it, which often happens in car checks near the border. Other types of sales and transportation are not permitted, although the general approach toward cannabis was lenient even before official decriminalisation.[187][188][189]

In Uruguay, President Jose Mujica signed legislation to legalize recreational cannabis in December 2013, making Uruguay the first country in the modern era to legalize cannabis. In August 2014, Uruguay legalized growing up to six plants at home, as well as the formation of growing clubs, and a state-controlled marijuana dispensary regime. Following Canada's 2015 election of Justin Trudeau and formation of a Liberal government, in 2017 the House of Commons passed a bill to legalize cannabis on 1 July 2018.[190]

The United Nations' World Drug Report stated that cannabis "was the world's most widely produced, trafficked, and consumed drug in the world in 2010", and estimated between 128 million and 238 million users globally in 2015.[191][192]

Society and culture

Global estimates of illegal drug users in 2014
(in millions of users)[193]
Substance Best
estimate
Low
estimate
High
estimate
Amphetamine-
type stimulants
35.65 15.34 55.90
Cannabis 182.50 127.54 233.65
Cocaine 18.26 14.88 22.08
Ecstasy 19.40 9.89 29.01
Opiates 17.44 13.74 21.59
Opioids 33.12 28.57 38.52

Legal status

 Cannabis propaganda sheet from 1935
Cannabis propaganda sheet from 1935

Since the beginning of the 20th century, most countries have enacted laws against the cultivation, possession or transfer of cannabis.[194] These laws have impacted adversely on the cannabis plant's cultivation for non-recreational purposes, but there are many regions where, under certain circumstances, handling of cannabis is legal or licensed. Many jurisdictions have lessened the penalties for possession of small quantities of cannabis so that it is punished by confiscation and sometimes a fine, rather than imprisonment, focusing more on those who traffic the drug on the black market.

In some areas where cannabis use had been historically tolerated, new restrictions were instituted, such as the closing of cannabis coffee shops near the borders of the Netherlands,[195] and closing of coffee shops near secondary schools in the Netherlands.[196] In Copenhagen, Denmark in 2014, mayor Frank Jensen discussed possibilities for the city to legalize cannabis production and commerce.[197]

Some jurisdictions use free voluntary treatment programs and/or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. Political parties, non-profit organizations, and causes based on the legalization of medical cannabis and/or legalizing the plant entirely (with some restrictions) have emerged in such countries as China and Thailand.[198][199]

In December 2012, the U.S. state of Washington became the first state to officially legalize cannabis in a state law (Washington Initiative 502) (but still illegal by federal law),[200] with the state of Colorado following close behind (Colorado Amendment 64).[201] On January 1, 2013, the first marijuana "club" for private marijuana smoking (no buying or selling, however) was allowed for the first time in Colorado.[202] The California Supreme Court decided in May 2013 that local governments can ban medical marijuana dispensaries despite a state law in California that permits the use of cannabis for medical purposes. At least 180 cities across California have enacted bans in recent years.[203]

In December 2013, Uruguay became the first country to legalize growing, sale and use of cannabis.[204] After a long delay in implementing the retail component of the law, in 2017 sixteen pharmacies were authorized to sell cannabis commercially.[205]

In November 2015, Uttarakhand became the first state of India to legalize the cultivation of hemp for industrial purposes.[206]

On October 17, 2015, Australian health minister Sussan Ley presented a new law that will allow the cultivation of cannabis for scientific research and medical trials on patients.[207] In December 2015, it was reported that the Canadian government had committed to legalizing cannabis, but at that time no timeline for the legalization was set out.[208]

As the drug has increasingly come to be seen as a health issue instead of criminal behavior, marijuana has also been legalized or decriminalized in: Czech Republic,[209] Colombia,[210][211] Ecuador,[212][213][214] Mexico,[215][216] Portugal,[217] and Canada.[218]

Usage

In 2013, between 128 and 232 million people used cannabis (2.7% to 4.9% of the global population between the ages of 15 and 65).[28] Cannabis is by far the most widely used illicit substance.[219]

United States

Between 1973 and 1978, eleven states decriminalized marijuana.[220] In 2001 Nevada reduced marijuana possession to a misdemeanor and since 2012, several other states have decriminalized and even legalized marijuana.[220]

In 2015, almost half of the people in the United States had tried marijuana, 12% had used it in the past year, and 7.3% had used it in the past month.[30] In 2014, daily marijuana use amongst US college students had reached its highest level since records began in 1980, rising from 3.5% in 2007 to 5.9% in 2014 and had surpassed daily cigarette use.[221]

In the US, men are over twice as likely to use marijuana as women and 18-29 year-olds are six times more likely to use as over 65-year-olds.[35] In 2015, a record 44% of the US population has tried marijuana in their lifetime, an increase from 38% in 2013 and 33% in 1985.[35]

Marijuana use in the United States is three times above the global average, but in line with other Western democracies. 44% of American 12th graders have tried the drug at least once, and the typical age of first-use is 16, similar to the typical age of first-use for alcohol but lower than the first-use age for other illicit drugs.[219]

Economics

Production

 Woman selling cannabis and bhang in Guwahati, Assam, India
Woman selling cannabis and bhang in Guwahati, Assam, India

It is often claimed by growers and breeders of herbal cannabis that advances in breeding and cultivation techniques have increased the potency of cannabis since the late 1960s and early '70s when THC was first discovered and understood. However, potent seedless cannabis such as "Thai sticks" were already available at that time. Sinsemilla (Spanish for "without seed") is the dried, seedless inflorescences of female cannabis plants. Because THC production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as hydroponics, cloning, high-intensity artificial lighting, and the sea of green method are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. It is often cited that the average levels of THC in cannabis sold in the United States rose dramatically between the 1970s and 2000, but such statements are likely skewed because undue weight is given to much more expensive and potent, but less prevalent samples.[222]

"Skunk" refers to several named strains of potent cannabis, grown through selective breeding and sometimes hydroponics. It is a cross-breed of Cannabis sativa and C. indica (although other strains of this mix exist in abundance). Skunk cannabis potency ranges usually from 6% to 15% and rarely as high as 20%. The average THC level in coffee shops in the Netherlands is about 18–19%.[223]

Price

The price or street value of cannabis varies widely depending on geographic area and potency.[224]

In the United States, cannabis is overall the number four value crop, and is number one or two in many states including California, New York and Florida, averaging $3,000 per pound ($6,600/kg).[225][226] Some believe it generates an estimated $36 billion market.[227] Some have argued that this estimate is methodologically flawed, and makes unrealistic assumptions about the level of marijuana consumption. Other estimates claiming to correct for this flaw claim that the market is between $2.1-$4.3 billion.[219] The United Nations Office on Drugs and Crime claims in its 2008 World Drug Report that typical U.S. retail prices are $10–15 per gram (approximately $280–420 per ounce). Street prices in North America are known to range from about $40–$400 per ounce ($1.4–$14/g), depending on quality.[228]

The European Monitoring Centre for Drugs and Drug Addiction reports that typical retail prices in Europe for cannabis varies from €2 to €20 per gram, with a majority of European countries reporting prices in the range €4–10.[229]

Gateway drug

The Gateway Hypothesis states that cannabis use increases the probability of trying "harder" drugs. The hypothesis has been hotly debated as it is regarded by some as the primary rationale for the United States prohibition on cannabis use.[230][231] A Pew Research Center poll found that political opposition to marijuana use was significantly associated with concerns about health effects and whether legalization would increase marijuana use by children.[232]

Some studies state that while there is no proof for the gateway hypothesis,[233] young cannabis users should still be considered as a risk group for intervention programs.[234] Other findings indicate that hard drug users are likely to be poly-drug users, and that interventions must address the use of multiple drugs instead of a single hard drug.[235] Almost two-thirds of the poly drug users in the "2009/10 Scottish Crime and Justice Survey" used cannabis.[236]

The gateway effect may appear due to social factors involved in using any illegal drug. Because of the illegal status of cannabis, its consumers are likely to find themselves in situations allowing them to acquaint with individuals using or selling other illegal drugs.[237][238] Utilizing this argument some studies have shown that alcohol and tobacco may additionally be regarded as gateway drugs;[239] however, a more parsimonious explanation could be that cannabis is simply more readily available (and at an earlier age) than illegal hard drugs. In turn alcohol and tobacco are easier to obtain at an earlier point than is cannabis (though the reverse may be true in some areas), thus leading to the "gateway sequence" in those individuals since they are most likely to experiment with any drug offered.[230]

An alternative to the gateway hypothesis is the common liability to addiction (CLA) theory. It states that some individuals are, for various reasons, willing to try multiple recreational substances. The "gateway" drugs are merely those that are (usually) available at an earlier age than the harder drugs. Researchers have noted in an extensive review that it is dangerous to present the sequence of events described in gateway "theory" in causative terms as this hinders both research and intervention.[240]

Research

Cannabis research is challenging since the plant is illegal in most countries.[241][242][243][244][245] Research-grade samples of the drug are difficult to obtain for research purposes, unless granted under authority of national governments.

There are also other difficulties in researching the effects of cannabis. Many people who smoke cannabis also smoke tobacco.[246] This causes confounding factors, where questions arise as to whether the tobacco, the cannabis, or both that have caused a cancer. Another difficulty researchers have is in recruiting people who smoke cannabis into studies. Because cannabis is an illegal drug in many countries, people may be reluctant to take part in research, and if they do agree to take part, they may not say how much cannabis they actually smoke.[247]

A 2015 review found that the use of high CBD-to-THC strains of cannabis showed significantly fewer positive symptoms such as delusions and hallucinations, better cognitive function and both lower risk for developing psychosis, as well as a later age of onset of the illness, compared to cannabis with low CBD-to-THC ratios.[248] A 2014 Cochrane review found that research was insufficient to determine the safety and efficacy to using cannabis to treat schizophrenia or psychosis.[249]

See also

Footnotes

  1. ^ Also referred to as "pot",[7] "weed",[8] "dope",[9] and "ganja" /ˈɡɑːndʒə/,[10] among many other nicknames[11] ("grass",[12] "herb",[13] "skunk",[14] "Mary Jane",[15] etc.).

^ b: Sources for this section and more information can be found in the Medical cannabis article

References

  1. ^ Mahmoud A. ElSohly (2007). Marijuana and the Cannabinoids. Springer. p. 8. ISBN 978-1-59259-947-9. 
  2. ^ a b c d e f United Nations. "World Drug Report 2013" (PDF). The united Nations. Retrieved 13 December 2014. 
  3. ^ "Medical Use of Marijuana". Health Canada. Retrieved 12 January 2015. 
  4. ^ "New Colombia Resources Inc Subsidiary, Sannabis, Produces First Batch of Medical Marijuana Based Products in Colombia to Fill Back Orders". prnewswire.com. PR Newswire. Retrieved 12 January 2015. 
  5. ^ Rana Moussaoui (Nov 25, 2013). "Lebanon cannabis trade thrives in shadow of Syrian war". AFP. 
  6. ^ a b Sanie Lopez Garelli (25 November 2008). "Mexico, Paraguay top pot producers, U.N. report says". CNN International. Retrieved 28 September 2013. 
  7. ^ "Pot – Definition". Merriam-Webster Dictionary. Retrieved 2012-10-09. 
  8. ^ "Weed – Definition". Merriam-Webster Dictionary. Retrieved 2012-10-09. 
  9. ^ "Dope – Definition". Merriam-Webster Dictionary. Retrieved 2017-07-17. 
  10. ^ "Ganja – Definition". Merriam-Webster Dictionary. Retrieved 2017-07-17. 
  11. ^ Pedro Ruiz, M.D.; Eric C. Strain (2011). Substance Abuse: A Comprehensive Textbook. Lippincott Williams & Wilkins. p. 214. ISBN 978-1-60547-277-5. 
  12. ^ "Grass – Definition". Merriam-Webster Dictionary. Retrieved 2012-10-09. 
  13. ^ "Herb – Definition". Merriam-Webster Dictionary. Retrieved 2012-10-09. 
  14. ^ "Skunk – Definition". American Heritage Dictionary of the English Language. Retrieved 2017-07-17. 
  15. ^ "Mary Jane – Definition". Merriam-Webster Dictionary. Retrieved 2017-07-17. 
  16. ^ Vij (2012). Textbook Of Forensic Medicine And Toxicology: Principles And Practice. Elsevier India. p. 672. ISBN 978-81-312-1129-8. See also article on Marijuana as a word.
  17. ^ Shorter Oxford English Dictionary (6th ed.), Oxford University Press, 2007, ISBN 978-0-19-920687-2 
  18. ^ Editors of the American Heritage Dictionaries (2007). Spanish Word Histories and Mysteries: English Words That Come From Spanish. Houghton Mifflin Harcourt. p. 142. ISBN 978-0-547-35021-9. 
  19. ^ Ethan B Russo (2013). Cannabis and Cannabinoids: Pharmacology, Toxicology, and Therapeutic Potential. Routledge. p. 28. ISBN 978-1-136-61493-4. 
  20. ^ Newton, David E. (2013). Marijuana : a reference handbook. Santa Barbara, Calif.: ABC-CLIO. p. 7. ISBN 9781610691499. 
  21. ^ a b c d e f "DrugFacts: Marijuana". National Institute on Drug Abuse. March 2016. Retrieved 19 April 2016. 
  22. ^ "Marijuana: Factsheets: Appetite". Adai.uw.edu. Retrieved 2013-07-12. 
  23. ^ a b Riviello, Ralph J. (2010). Manual of forensic emergency medicine : a guide for clinicians. Sudbury, Mass.: Jones and Bartlett Publishers. p. 41. ISBN 9780763744625. 
  24. ^ "Marijuana intoxication: MedlinePlus Medical Encyclopedia". Nlm.nih.gov. Retrieved 2013-07-12. 
  25. ^ Crippa JA, Zuardi AW, Martín-Santos R, Bhattacharyya S, Atakan Z, McGuire P, Fusar-Poli P (October 2009). "Cannabis and anxiety: a critical review of the evidence". Human Psychopharmacology. 24 (7): 515–23. doi:10.1002/hup.1048. PMID 19693792. 
  26. ^ a b Leweke FM, Mueller JK, Lange B, Rohleder C (April 2016). "Therapeutic Potential of Cannabinoids in Psychosis". Biological Psychiatry. 79 (7): 604–12. doi:10.1016/j.biopsych.2015.11.018. PMID 26852073. 
  27. ^ a b Ksir C, Hart CL (February 2016). "Cannabis and Psychosis: a Critical Overview of the Relationship". Current Psychiatry Reports. 18 (2): 12. doi:10.1007/s11920-015-0657-y. PMID 26781550. 
  28. ^ a b c "Status and Trend Analysis of Illict [sic] Drug Markets". World Drug Report 2015 (PDF). p. 23. Retrieved 26 June 2015. 
  29. ^ "Marijuana use and support for legal marijuana continue to climb". 
  30. ^ a b Motel, Seth (14 April 2015). "6 facts about marijuana". Pew Research Center. Retrieved 26 June 2015. 
  31. ^ Martin Booth (2003). Cannabis: A History. Transworld. p. 36. ISBN 978-1-4090-8489-1. 
  32. ^ "Cannabis: Legal Status". Erowid.org. Retrieved 2011-10-30. 
  33. ^ UNODC. World Drug Report 2010. United Nations Publication. p. 198. Retrieved 2010-07-19. 
  34. ^ "23 Legal Medical Marijuana States and DC Laws, Fees, and Possession Limits". ProCon. Retrieved 8 May 2015. 
  35. ^ a b c Gallup, Inc. "More Than Four in 10 Americans Say They Have Tried Marijuana". Gallup.com. 
  36. ^ Linshi, Jack (2014-06-26). "Americans Are Smoking More Pot". Time. 
  37. ^ Murnion B (December 2015). "Medicinal cannabis". Australian Prescriber. 38 (6): 212–5. doi:10.18773/austprescr.2015.072. PMC 4674028Freely accessible. PMID 26843715. 
  38. ^ "What is medical marijuana?". National Institute of Drug Abuse. July 2015. Retrieved 19 April 2016. The term medical marijuana refers to using the whole unprocessed marijuana plant or its basic extracts to treat a disease or symptom. 
  39. ^ "Release the strains". Nature Medicine. 21 (9): 963. September 2015. doi:10.1038/nm.3946. PMID 26340110. Retrieved 8 September 2015. 
  40. ^ a b c Borgelt LM, Franson KL, Nussbaum AM, Wang GS (February 2013). "The pharmacologic and clinical effects of medical cannabis". Pharmacotherapy. 33 (2): 195–209. doi:10.1002/phar.1187. PMID 23386598. 
  41. ^ a b c d Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J (23 June 2015). "Cannabinoids for Medical Use: A Systematic Review and Meta-analysis". JAMA. 313 (24): 2456–73. doi:10.1001/jama.2015.6358. PMID 26103030. 
  42. ^ Jensen B, Chen J, Furnish T, Wallace M (October 2015). "Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence". Current Pain and Headache Reports. 19 (10): 50. doi:10.1007/s11916-015-0524-x. PMID 26325482. 
  43. ^ Emmanuel S Onaivi; Takayuki Sugiura; Vincenzo Di Marzo (2005). Endocannabinoids: The Brain and Body's Marijuana and Beyond. Taylor & Francis. p. 58. ISBN 978-0-415-30008-7. 
  44. ^ http://cannabislink.ca/info/MotivationsforCannabisUsebyCanadianAdults-2008.pdf[full citation needed]
  45. ^ "Medication-Associated Depersonalization Symptoms" 
  46. ^ Shufman E, Lerner A, Witztum E (April 2005). "[Depersonalization after withdrawal from cannabis usage]" (PDF). Harefuah (in Hebrew). 144 (4): 249–51, 303. PMID 15889607. Archived from the original (PDF) on April 30, 2005. 
  47. ^ Johnson BA (February 1990). "Psychopharmacological effects of cannabis". British Journal of Hospital Medicine. 43 (2): 114–6, 118–20, 122. PMID 2178712. 
  48. ^ Wayne Hall; Rosalie Liccardo Pacula (2003). Cannabis Use and Dependence: Public Health and Public Policy. Cambridge University Press. p. 38. ISBN 978-0-521-80024-2. 
  49. ^ Mathre, Mary Lynn, ed. (1997). Cannabis in Medical Practice: A Legal, Historical, and Pharmacological Overview of the Therapeutic Use of Marijuana. University of Virginia Medical Center. pp. 144–. ISBN 978-0-7864-8390-7. 
  50. ^ Riedel G, Davies SN (2005). "Cannabinoid function in learning, memory and plasticity". Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology. 168 (168): 445–77. doi:10.1007/3-540-26573-2_15. ISBN 3-540-22565-X. PMID 16596784. 
  51. ^ Barceloux, Donald G (20 March 2012). "Chapter 60: Marijuana (Cannabis sativa L.) and synthetic cannabinoids". Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. John Wiley & Sons. p. 915. ISBN 978-0-471-72760-6.
  52. ^ a b Goldenberg M, IsHak WW, Danovitch I (January 2017). "Quality of life and recreational cannabis use". The American Journal on Addictions. 26 (1): 8–25. doi:10.1111/ajad.12486. PMID 28000973. 
  53. ^ Ayyagari, Shalini (2007). ""Hori Hai": A Festival of Colours!! (review)". Asian Music. Johns Hopkins University Press. 38 (2): 151–153. doi:10.1353/amu.2007.0029. 
  54. ^ "Brazilian Archives of Biology and Technology – Jurema-Preta (Mimosa tenuiflora [Willd.] Poir.): a review of its traditional use, phytochemistry and pharmacology". scielo.br. Retrieved 2009-01-14. 
  55. ^ Courtwright, David (2001). Forces of Habit: Drugs and the Making of the Modern World. Harvard Univ. Press. p. 39. ISBN 0-674-00458-2. 
  56. ^ Andrew Golub (2012). The Cultural/Subcultural Contexts of Marijuana Use at the Turn of the Twenty-First Century. Routledge. p. 82. ISBN 978-1-136-44627-6. 
  57. ^ Allan Tasman; Jerald Kay; Jeffrey A. Lieberman; Michael B. First; Mario Maj (2011). Psychiatry. John Wiley & Sons. p. 9. ISBN 978-1-119-96540-4. 
  58. ^ Ed Rosenthal (2002). Ask Ed: Marijuana Gold: Trash to Stash. Perseus Books Group. p. 15. ISBN 978-1-936807-02-4. 
  59. ^ "Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?" (PDF). Cannabis-med.org. Retrieved 2014-04-07. 
  60. ^ Dronabinol in the ChemIDplus database
  61. ^ Dale Gieringer, Ph.D.; Ed Rosenthal (2008). Marijuana medical handbook: practical guide to therapeutic uses of marijuana. QUICK AMER Publishing Company. p. 182. ISBN 978-0-932551-86-3. 
  62. ^ Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". Lancet. 369 (9566): 1047–53. doi:10.1016/s0140-6736(07)60464-4. PMID 17382831. 
  63. ^ "Drug Abuse Warning Network, 2011. National Estimates of Drug-Related Emergency Department Visits" (PDF). U.S. Department of Health and Human Services. 2011. Retrieved 2015-05-08. 
  64. ^ "www.samhsa.gov". 
  65. ^ a b c d Volkow ND, Baler RD, Compton WM, Weiss SR (June 2014). "Adverse health effects of marijuana use". The New England Journal of Medicine. 370 (23): 2219–27. doi:10.1056/NEJMra1402309. PMC 4827335Freely accessible. PMID 24897085. 
  66. ^ Gordon AJ, Conley JW, Gordon JM (December 2013). "Medical consequences of marijuana use: a review of current literature". Current Psychiatry Reports. 15 (12): 419. doi:10.1007/s11920-013-0419-7. PMID 24234874. 
  67. ^ "Committee Opinion No. 637: Marijuana Use During Pregnancy and Lactation". Obstetrics and Gynecology. 126 (1): 234–8. July 2015. doi:10.1097/01.AOG.0000467192.89321.a6. PMID 26241291. 
  68. ^ Gunn JK, Rosales CB, Center KE, Nuñez A, Gibson SJ, Christ C, Ehiri JE (April 2016). "Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis". BMJ Open. 6 (4): e009986. doi:10.1136/bmjopen-2015-009986. PMID 27048634. 
  69. ^ Conner SN, Bedell V, Lipsey K, Macones GA, Cahill AG, Tuuli MG (October 2016). "Maternal Marijuana Use and Adverse Neonatal Outcomes: A Systematic Review and Meta-analysis". Obstetrics and Gynecology. 128 (4): 713–23. doi:10.1097/AOG.0000000000001649. PMID 27607879. 
  70. ^ Subbaraman MS (8 January 2014). "Can cannabis be considered a substitute medication for alcohol?". Alcohol and Alcoholism. 49 (3): 292–8. doi:10.1093/alcalc/agt182. PMC 3992908Freely accessible. PMID 24402247. 
  71. ^ Sorensen CJ, DeSanto K, Borgelt L, Phillips KT, Monte AA (March 2017). "Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment-a Systematic Review". Journal of Medical Toxicology. 13 (1): 71–87. doi:10.1007/s13181-016-0595-z. PMC 5330965Freely accessible. PMID 28000146. 
  72. ^ a b Hall W, Solowij N (November 1998). "Adverse effects of cannabis". Lancet. 352 (9140): 1611–6. doi:10.1016/S0140-6736(98)05021-1. PMID 9843121. 
  73. ^ Oltmanns T, Emery R (2015). Abnormal Psychology. New Jersey: Pearson. p. 294. ISBN 0205970745. 
  74. ^ "Sativex Oral Mucosal Spray Public Assessment Report. Decentralized Procedure" (PDF). United Kingdom Medicines and Healthcare Products Regulatory Agency. p. 93. Retrieved 2015-05-07. There is clear evidence that recreational cannabis can produce a transient toxic psychosis in larger doses or in susceptible individuals, which is said to characteristically resolve within a week or so of absence (Johns 2001). Transient psychotic episodes as a component of acute intoxication are well-documented (Hall et al 1994) 
  75. ^ D'Souza DC, Sewell RA, Ranganathan M (October 2009). "Cannabis and psychosis/schizophrenia: human studies". European Archives of Psychiatry and Clinical Neuroscience. 259 (7): 413–31. doi:10.1007/s00406-009-0024-2. PMC 2864503Freely accessible. PMID 19609589. 
  76. ^ Lubman DI, Cheetham A, Yücel M (April 2015). "Cannabis and adolescent brain development". Pharmacology & Therapeutics. 148: 1–16. doi:10.1016/j.pharmthera.2014.11.009. PMID 25460036. 
  77. ^ Stephen Maisto; Mark Galizio; Gerard Connors (2014). Drug Use and Abuse. Cengage Learning. p. 278. ISBN 978-1-305-17759-8. 
  78. ^ Owen KP, Sutter ME, Albertson TE (February 2014). "Marijuana: respiratory tract effects". Clinical Reviews in Allergy & Immunology. 46 (1): 65–81. doi:10.1007/s12016-013-8374-y. PMID 23715638. 
  79. ^ Tetrault JM, Crothers K, Moore BA, Mehra R, Concato J, Fiellin DA (February 2007). "Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review". Archives of Internal Medicine. 167 (3): 221–8. doi:10.1001/archinte.167.3.221. PMC 2720277Freely accessible. PMID 17296876. 
  80. ^ Hashibe M, Straif K, Tashkin DP, Morgenstern H, Greenland S, Zhang ZF (April 2005). "Epidemiologic review of marijuana use and cancer risk". Alcohol. 35 (3): 265–75. doi:10.1016/j.alcohol.2005.04.008. PMID 16054989. 
  81. ^ "Does smoking cannabis cause cancer?". Cancer Research UK. 2010-09-20. Archived from the original on 2012-07-29. Retrieved 2013-01-09. 
  82. ^ Tashkin, Donald (March 1997). "Effects of marijuana on the lung and its immune defenses". UCLA School of Medicine. Retrieved 2012-06-23. 
  83. ^ Gates P, Jaffe A, Copeland J (July 2014). "Cannabis smoking and respiratory health: consideration of the literature". Respirology. 19 (5): 655–62. doi:10.1111/resp.12298. PMID 24831571. 
  84. ^ Huang YH, Zhang ZF, Tashkin DP, Feng B, Straif K, Hashibe M (January 2015). "An epidemiologic review of marijuana and cancer: an update". Cancer Epidemiology, Biomarkers & Prevention. 24 (1): 15–31. doi:10.1158/1055-9965.EPI-14-1026. PMC 4302404Freely accessible. PMID 25587109. 
  85. ^ Tashkin DP (June 2013). "Effects of marijuana smoking on the lung". Annals of the American Thoracic Society. 10 (3): 239–47. doi:10.1513/annalsats.201212-127fr. PMID 23802821. 
  86. ^ Gurney J, Shaw C, Stanley J, Signal V, Sarfati D (November 2015). "Cannabis exposure and risk of testicular cancer: a systematic review and meta-analysis". BMC Cancer. 15 (1): 897. doi:10.1186/s12885-015-1905-6. PMC 4642772Freely accessible. PMID 26560314. 
  87. ^ Zhang LR, Morgenstern H, Greenland S, Chang SC, Lazarus P, Teare MD, Woll PJ, Orlow I, Cox B, Brhane Y, Liu G, Hung RJ (February 2015). "Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium". International Journal of Cancer. 136 (4): 894–903. doi:10.1002/ijc.29036. PMC 4262725Freely accessible. PMID 24947688. 
  88. ^ de Carvalho MF, Dourado MR, Fernandes IB, Araújo CT, Mesquita AT, Ramos-Jorge ML (December 2015). "Head and neck cancer among marijuana users: a meta-analysis of matched case-control studies". Archives of Oral Biology. 60 (12): 1750–5. doi:10.1016/j.archoralbio.2015.09.009. PMID 26433192. 
  89. ^ A. Riecher-Rössler (2014). Comorbidity of Mental and Physical Disorders. Karger Medical and Scientific Publishers. p. 88. ISBN 978-3-318-02604-7. 
  90. ^ Ravi D, Ghasemiesfe M, Korenstein D, Cascino T, Keyhani S (February 2018). "Associations Between Marijuana Use and Cardiovascular Risk Factors and Outcomes: A Systematic Review". Annals of Internal Medicine. 168 (3): 187–194. doi:10.7326/M17-1548. PMID 29357394. 
  91. ^ Cottencin O, Karila L, Lambert M, Arveiller C, Benyamina A, Boissonas A, Goudemand M, Reynaud M (December 2010). "Cannabis arteritis: review of the literature". Journal of Addiction Medicine (Review). 4 (4): 191–6. doi:10.1097/ADM.0b013e3181beb022. PMID 21769037. 
  92. ^ Hackam DG (March 2015). "Cannabis and stroke: systematic appraisal of case reports". Stroke. 46 (3): 852–6. doi:10.1161/STROKEAHA.115.008680. PMID 25700287. 
  93. ^ Thomas G, Kloner RA, Rezkalla S (January 2014). "Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know". The American Journal of Cardiology. 113 (1): 187–90. doi:10.1016/j.amjcard.2013.09.042. PMID 24176069. 
  94. ^ Jones RT (November 2002). "Cardiovascular system effects of marijuana". Journal of Clinical Pharmacology (Review). 42 (11 Suppl): 58S–63S. doi:10.1002/j.1552-4604.2002.tb06004.x. PMID 12412837. 
  95. ^ a b c Hall W (January 2015). "What has research over the past two decades revealed about the adverse health effects of recreational cannabis use?". Addiction. 110 (1): 19–35. doi:10.1111/add.12703. PMID 25287883. 
  96. ^ Franz CA, Frishman WH (9 February 2016). "Marijuana Use and Cardiovascular Disease". Cardiology in Review. 24 (4): 158–62. doi:10.1097/CRD.0000000000000103. PMID 26886465. 
  97. ^ Lorenzetti V, Solowij N, Yücel M (April 2016). "The Role of Cannabinoids in Neuroanatomic Alterations in Cannabis Users". Biological Psychiatry. 79 (7): e17–31. doi:10.1016/j.biopsych.2015.11.013. PMID 26858212. 
  98. ^ a b Batalla A, Bhattacharyya S, Yücel M, Fusar-Poli P, Crippa JA, Nogué S, Torrens M, Pujol J, Farré M, Martin-Santos R (2013). "Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings". PLOS One. 8 (2): e55821. doi:10.1371/journal.pone.0055821. PMC 3563634Freely accessible. PMID 23390554. 
  99. ^ Nader DA, Sanchez ZM (12 May 2017). "Effects of regular cannabis use on neurocognition, brain structure, and function: a systematic review of findings in adults". The American Journal of Drug and Alcohol Abuse. 44 (1): 4–18. doi:10.1080/00952990.2017.1306746. PMID 28498718. 
  100. ^ a b Martín-Santos R, Fagundo AB, Crippa JA, Atakan Z, Bhattacharyya S, Allen P, Fusar-Poli P, Borgwardt S, Seal M, Busatto GF, McGuire P (March 2010). "Neuroimaging in cannabis use: a systematic review of the literature". Psychological Medicine. 40 (3): 383–98. doi:10.1017/S0033291709990729. PMID 19627647. 
  101. ^ Rocchetti M, Crescini A, Borgwardt S, Caverzasi E, Politi P, Atakan Z, Fusar-Poli P (November 2013). "Is cannabis neurotoxic for the healthy brain? A meta-analytical review of structural brain alterations in non-psychotic users". Psychiatry and Clinical Neurosciences. 67 (7): 483–92. doi:10.1111/pcn.12085. PMID 24118193. 
  102. ^ Norberg MM, Kavanagh DJ, Olivier J, Lyras S (November 2016). "Craving cannabis: a meta-analysis of self-report and psychophysiological cue-reactivity studies". Addiction. 111 (11): 1923–1934. doi:10.1111/add.13472. PMID 27239052. 
  103. ^ Colizzi M, McGuire P, Pertwee RG, Bhattacharyya S (May 2016). "Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence". Neuroscience and Biobehavioral Reviews. 64: 359–81. doi:10.1016/j.neubiorev.2016.03.010. PMID 26987641. 
  104. ^ Schreiner AM, Dunn ME (October 2012). "Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis". Experimental and Clinical Psychopharmacology. 20 (5): 420–429. doi:10.1037/a0029117. PMID 22731735. 
  105. ^ Crean RD, Crane NA, Mason BJ (March 2011). "An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions". Journal of Addiction Medicine. 5 (1): 1–8. doi:10.1097/ADM.0b013e31820c23fa. PMC 3037578Freely accessible. PMID 21321675. 
  106. ^ a b Calabria B, Degenhardt L, Hall W, Lynskey M (May 2010). "Does cannabis use increase the risk of death? Systematic review of epidemiological evidence on adverse effects of cannabis use". Drug and Alcohol Review. 29 (3): 318–30. doi:10.1111/j.1465-3362.2009.00149.x. PMID 20565525. 
  107. ^ Borges G, Bagge CL, Orozco R (May 2016). "A literature review and meta-analyses of cannabis use and suicidality". Journal of Affective Disorders. 195: 63–74. doi:10.1016/j.jad.2016.02.007. PMID 26872332. 
  108. ^ Lev-Ran S, Roerecke M, Le Foll B, George TP, McKenzie K, Rehm J (March 2014). "The association between cannabis use and depression: a systematic review and meta-analysis of longitudinal studies". Psychological Medicine. 44 (4): 797–810. doi:10.1017/S0033291713001438. PMID 23795762. 
  109. ^ Thompson, Kara; Leadbeater, Bonnie (6 June 2018), Ten-year study on cannabis use by youth reveals distressing results, St. Francis Xavier University, retrieved 7 June 2018 
  110. ^ van Holst RJ, Schilt T (March 2011). "Drug-related decrease in neuropsychological functions of abstinent drug users". Current Drug Abuse Reviews. 4 (1): 42–56. doi:10.2174/1874473711104010042. PMID 21466500. 
  111. ^ "Withdrawal Symptoms From Smoking Pot?". WebMD. 
  112. ^ Hall W, Degenhardt L (October 2009). "Adverse health effects of non-medical cannabis use". Lancet. 374 (9698): 1383–91. doi:10.1016/s0140-6736(09)61037-0. PMID 19837255. 
  113. ^ Subbaraman MS (2014). "Can cannabis be considered a substitute medication for alcohol?". Alcohol and Alcoholism. 49 (3): 292–8. doi:10.1093/alcalc/agt182. PMC 3992908Freely accessible. PMID 24402247. 
  114. ^ Wilkinson ST, Yarnell S, Radhakrishnan R, Ball SA, D'Souza DC (14 January 2016). "Marijuana Legalization: Impact on Physicians and Public Health". Annual Review of Medicine. 67 (1): 453–66. doi:10.1146/annurev-med-050214-013454. PMC 4900958Freely accessible. PMID 26515984. 
  115. ^ Li MC, Brady JE, DiMaggio CJ, Lusardi AR, Tzong KY, Li G (4 October 2011). "Marijuana use and motor vehicle crashes". Epidemiologic Reviews. 34 (1): 65–72. doi:10.1093/epirev/mxr017. PMC 3276316Freely accessible. PMID 21976636. 
  116. ^ Rogeberg O, Elvik R (August 2016). "The effects of cannabis intoxication on motor vehicle collision revisited and revised". Addiction. 111 (8): 1348–59. doi:10.1111/add.13347. PMID 26878835. 
  117. ^ a b Wayne Hall; Rosalie Liccardo Pacula (2003). Cannabis Use and Dependence: Public Health and Public Policy. Cambridge University Press. p. 15. ISBN 978-0-521-80024-2. 
  118. ^ Leo E. Hollister; et al. (March 1986). "Health aspects of cannabis". Pharma Review (38): 1–20. Archived from the original on 2013-04-15. Retrieved 2011-02-17. 
  119. ^ Juan Iovanna; Uktam Ismailov (2009). Pancreatology: From Bench to Bedside. Springer. p. 40. ISBN 978-3-642-00152-9. 
  120. ^ Wilson RI, Nicoll RA (April 2002). "Endocannabinoid signaling in the brain". Science. 296 (5568): 678–82. doi:10.1126/science.1063545. PMID 11976437. 
  121. ^ Fernandez, J.; Allison, B. (2004). "Rimbonabant Sanofi-Synthelabo". Current Opinion in Investigational Drugs (5): 430–435. 
  122. ^ Atta-ur- Rahman; Allen B. Reitz (2005). Frontiers in Medicinal Chemistry. Bentham Science Publishers. p. 150. ISBN 978-1-60805-205-9. 
  123. ^ Oleson EB, Cheer JF (August 2012). "A brain on cannabinoids: the role of dopamine release in reward seeking". Cold Spring Harbor Perspectives in Medicine. 2 (8): a012229. doi:10.1101/cshperspect.a012229. PMC 3405830Freely accessible. PMID 22908200. 
  124. ^ Kathmann M, Flau K, Redmer A, Tränkle C, Schlicker E (February 2006). "Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 372 (5): 354–61. doi:10.1007/s00210-006-0033-x. PMID 16489449. 
  125. ^ Hejazi N, Zhou C, Oz M, Sun H, Ye JH, Zhang L (March 2006). "Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors" (PDF). Molecular Pharmacology. 69 (3): 991–7. doi:10.1124/mol.105.019174. PMID 16332990. 
  126. ^ a b c Donald G. Barceloux (3 February 2012). Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. John Wiley & Sons. pp. 910–. ISBN 978-1-118-10605-1. Retrieved 14 July 2013. 
  127. ^ Randall Clint Baselt (2008). Disposition of Toxic Drugs and Chemicals in Man. Biomedical Publications. pp. 1513–1518. ISBN 978-0-9626523-7-0. 
  128. ^ Leslie M. Shaw; Tai C. Kwong (2001). The Clinical Toxicology Laboratory: Contemporary Practice of Poisoning Evaluation. Amer. Assoc. for Clinical Chemistry. p. 51. ISBN 978-1-890883-53-9. 
  129. ^ John Kelly (2010-06-28). "Has the most common marijuana test resulted in tens of thousands of wrongful convictions?". AlterNet. 
  130. ^ Venkatratnam A, Lents NH (July 2011). "Zinc reduces the detection of cocaine, methamphetamine, and THC by ELISA urine testing". Journal of Analytical Toxicology. 35 (6): 333–40. doi:10.1093/anatox/35.6.333. PMID 21740689. 
  131. ^ Lin CN, Strathmann FG (July 10, 2013). "Elevated urine zinc concentration reduces the detection of methamphetamine, cocaine, THC and opiates in urine by EMIT" (PDF). Journal of Analytical Toxicology. 37 (9): 665–9. doi:10.1093/jat/bkt056. PMID 23843421. 
  132. ^ a b c J. E. Joy; S. J. Watson, Jr.; J. A. Benson, Jr. (1999). Marijuana and Medicine: Assessing The Science Base. Washington, D.C.: National Academy of Sciences Press. ISBN 0-585-05800-8. 
  133. ^ a b c "Why Does Cannabis Potency Matter?". United Nations Office on Drugs and Crime. 2009-06-29. 
  134. ^ Cascini F, Aiello C, Di Tanna G (March 2012). "Increasing delta-9-tetrahydrocannabinol (Δ-9-THC) content in herbal cannabis over time: systematic review and meta-analysis". Current Drug Abuse Reviews. 5 (1): 32–40. doi:10.2174/1874473711205010032. PMID 22150622. 
  135. ^ Dana Smith. "Cannabis and memory loss: dude, where's my CBD?". the Guardian. 
  136. ^ "Cannabis Potency". National Cannabis Prevention and Information Centre. Archived from the original on 2011-12-06. Retrieved 2011-12-13. 
  137. ^ "BBC: Cannabis laws to be strengthened. May 2008 20:55 UK". BBC News. 2008-05-07. Retrieved 2010-09-20. 
  138. ^ Di Forti M, Morgan C, Dazzan P, Pariante C, Mondelli V, Marques TR, Handley R, Luzi S, et al. (December 2009). "High-potency cannabis and the risk of psychosis". The British Journal of Psychiatry. 195 (6): 488–91. doi:10.1192/bjp.bp.109.064220. PMC 2801827Freely accessible. PMID 19949195. 
  139. ^ Hope, Christopher (2008-02-06). "Use of extra strong 'skunk' cannabis soars". The Daily Telegraph. London. 
  140. ^ Harold Doweiko (2011). Concepts of Chemical Dependency. Cengage Learning. p. 124. ISBN 1-133-17081-1. 
  141. ^ Editors of the American Heritage Dictionaries (2007). Spanish Word Histories and Mysteries: English Words That Come From Spanish. Houghton Mifflin Harcourt. p. 142. ISBN 0-547-35021-X. 
  142. ^ Dr Gary Potter; Mr Martin Bouchard; Mr Tom Decorte (2013). World Wide Weed: Global Trends in Cannabis Cultivation and its Control (revised ed.). Ashgate Publishing, Ltd. p. 17. ISBN 978-1-4094-9438-6. 
  143. ^ Wayne Hall; Rosalie Liccardo Pacula (2003). Cannabis Use and Dependence: Public Health and Public Policy. Cambridge University Press. p. 13. ISBN 978-0-521-80024-2. 
  144. ^ United Nations Office on Drugs and Crime (2009). Recommended Methods for the Identification and Analysis of Cannabis and Cannabis Products. United Nations Publications. p. 15. ISBN 978-92-1-148242-3. 
  145. ^ a b Max M. Houck (2015). Forensic Chemistry. Elsevier Science. p. 131. ISBN 978-0-12-800624-5. 
  146. ^ Patricia A. Adler; Peter Adler; Patrick K. O'Brien (February 28, 2012). Drugs and the American Dream: An Anthology. John Wiley & Sons. pp. 330–. ISBN 978-0-470-67027-9. 
  147. ^ Clayton J. Mosher; Scott M. Akins (August 20, 2013). Drugs and Drug Policy: The Control of Consciousness Alteration. SAGE Publications. p. 17. ISBN 978-1-4833-2188-2. 
  148. ^ "Hemp Facts". Naihc.org. Retrieved 2013-01-09. 
  149. ^ Earleywine, Mitch (2002). Understanding Marijuana: A New Look at the Scientific Evidence. Oxford University Press. p. 3. ISBN 978-0-19-988143-7. 
  150. ^ Ed Rosenthal (2002). Ask Ed : Marijuana Gold: Trash to Stash. QUICK AMER Publishing Company. p. 116. ISBN 978-0-932551-52-8. 
  151. ^ "Kief". Cannabisculture.com. 2005-03-09. Archived from the original on 2009-06-05. Retrieved 2010-01-02. 
  152. ^ David Bukszpan (2012). Is That a Word?: From AA to ZZZ, the Weird and Wonderful Language of SCRABBLE. Chronicle Books. p. 94. ISBN 978-1-4521-0824-7. 
  153. ^ "Hashish". dictionary.reference.com. 
  154. ^ Castle/Murray/D'Souza (2004). Marijuana and Madness. Cambridge University Press. p. 35. ISBN 978-1-139-50267-2. 
  155. ^ Raymond Goldberg (2012). Drugs Across the Spectrum, 7th ed. Cengage Learning. p. 255. ISBN 978-1-133-59416-1. 
  156. ^ Alchimia Blog, Rosin Hash
  157. ^ Leslie L. Iversen (2000). The Science of Marijuana. Oxford University Press. p. 17. ISBN 978-0-19-515110-7. 
  158. ^ Jeffrey A. Cohen; Richard A. Rudick (2011). Multiple Sclerosis Therapeutics. Cambridge University Press. p. 670. ISBN 978-1-139-50237-5. 
  159. ^ Leslie A. King (2009). Forensic Chemistry of Substance Misuse: A Guide to Drug Control. Royal Society of Chemistry. p. 78. ISBN 978-0-85404-178-7. 
  160. ^ "Dabs—marijuana's explosive secret". Cnbc.com. 2014-02-24. Retrieved 2014-02-28. 
  161. ^ World Drug Report. United Nations Publications. 2009. p. 98. 
  162. ^ Alison Hallett for Wired. Feb. 20, 2013 Hash Oil is Blowing Up Across the U.S. –Literally
  163. ^ Pascal Kintz (2014). Toxicological Aspects of Drug-Facilitated Crimes. Elsevier Science. p. 141. ISBN 978-0-12-416969-2. 
  164. ^ Elise McDonough; Editors of High Times Magazine (2012). The Official High Times Cannabis Cookbook: More Than 50 Irresistible Recipes That Will Get You High. Chronicle Books. p. 17. ISBN 978-1-4521-0133-0. 
  165. ^ Michael Backes (2014). Cannabis Pharmacy: The Practical Guide to Medical Marijuana. Hachette Books. p. 46. ISBN 978-1-60376-334-9. 
  166. ^ "Marijuana and the Cannabinoids", ElSohly (p. 8).
  167. ^ Stafford PG, Bigwood J (1992). Psychedelics Encyclopedia. Ronin Publishing. p. 157. ISBN 978-0-914171-51-5. 
  168. ^ Barber EJ (1992). Prehistoric Textiles: The Development of Cloth in the Neolithic and Bronze Ages with Special Reference to the Aegean. Princeton University Press. p. 17. 
  169. ^ Rudgley R (1998). Little, Brown, et al., eds. The Encyclopedia of Psychoactive Substances. ISBN 0-349-11127-8. 
  170. ^ Franck, Mel (1997). Marijuana Grower's Guide. Red Eye Press. p. 3. ISBN 0-929349-03-2. 
  171. ^ Rubin, Vera D (1976). Cannabis and Culture. Campus Verlag. p. 305. ISBN 3-593-37442-0. 
  172. ^ Cunliffe, Barry W (2001). The Oxford Illustrated History of Prehistoric Europe. Oxford University Press. p. 405. ISBN 0-19-285441-0. 
  173. ^ Walton, Robert P (1938). Marijuana, America's New Drug Problem. JB Lippincott. p. 6. 
  174. ^ Ibn Taymiyya (2001). Le haschich et l'extase (in French). Beyrouth: Albouraq. ISBN 2-84161-174-4. 
  175. ^ Vera Rubin (1 January 1975). Cannabis and Culture. Walter de Gruyter. pp. 77–. ISBN 978-3-11-081206-0. Cannabis Smoking in 13th-14th Century Ethiopia: Chemical Evidence 
  176. ^ Leslie L. Iversen (7 December 2007). The Science of Marijuana. Oxford University Press. pp. 110–. ISBN 978-0-19-988693-7. 
  177. ^ A Collection of the Laws of Mauritius and Its Dependencies. By the authority of the Government. 1867. pp. 541–. 
  178. ^ Nanthawan Bunyapraphatsō̜n (1999). Medicinal and poisonous plants. Backhuys Publishers. p. 169. ISBN 978-90-5782-042-7. 
  179. ^ "Statement of Dr. William C. Woodward". Drug library. Retrieved 2010-09-20. 
  180. ^ "Debunking the Hemp Conspiracy Theory". 
  181. ^ The Opium and Narcotic Drug Act, 1923, S.C. 1923, c. 22
  182. ^ W. W. Willoughby (1925). "Opium as an international problem". Baltimore: The Johns Hopkins Press. Retrieved 2010-09-20. 
  183. ^ Opium as an international problem: the Geneva conferences – Westel Woodbury Willoughby at Google Books
  184. ^ Pub.L. 75–238, 50 Stat. 551, enacted August 2, 1937
  185. ^ Martin Booth (1 June 2005). Cannabis: A History. Picador. pp. 338–. ISBN 978-0-312-42494-7. 
  186. ^ Michael Tonry (22 September 2015). Crime and Justice, Volume 44: A Review of Research. University of Chicago Press. pp. 261–. ISBN 978-0-226-34102-6. 
  187. ^ Use drop-down menu on site to view Netherlands entry.), Eldd.emcdda.europa.eu, retrieved 2011-02-17 
  188. ^ Drugs Policy in the Netherlands, Ukcia.org, retrieved 2011-02-17 
  189. ^ "Amsterdam Will Ban Tourists from Pot Coffee Shops". Atlantic Wire. 27 May 2011. Retrieved 2011-06-23. 
  190. ^ http://www.cbc.ca/news/politics/cannabis-legalization-legislation-1.4421910
  191. ^ Eliana Dockterman (29 June 2012). "Marijuana Now the Most Popular Drug in the World". Time NewsFeed. Time Inc. Retrieved 16 March 2013. 
  192. ^ UNODC. World Drug Report Fact Sheet (2017).  Missing or empty |title= (help)
  193. ^ "Statistical tables". World Drug Report 2016 (pdf). Vienna, Austria: United Nations Office on Drugs and Crime. 2016. ISBN 9789210578622. Retrieved 1 August 2016. 
  194. ^ David Levinson (2002). Encyclopedia of Crime and Punishment. SAGE Publications. p. 572. ISBN 978-0-7619-2258-2. 
  195. ^ "Many Dutch coffee shops close as liberal policies change, Exaptica". Expatica.com. 2007-11-27. Retrieved 2010-09-20. 
  196. ^ "43 Amsterdam coffee shops to close door", Radio Netherlands, Friday 21 November 2008 Archived December 2, 2008, at the Wayback Machine.
  197. ^ O'Sullivan, Feargus (3 March 2014). "Why the Mayor of Copenhagen Wants to Get Into the Marijuana Business". Retrieved 23 January 2018. 
  198. ^ Johnston, Ian (5 January 2014). "As cannabis is widely legalised, China cashes in on an unprecedented boom". Independent. Retrieved 23 January 2018. 
  199. ^ Liljas, Per (3 June 2017). "Could Thailand, which gave world the bong, legalise cannabis for medicinal use? After failed war on drugs, attitudes have softened". Post Magazine. Retrieved 23 January 2018. 
  200. ^ "Marijuana goes legal in Washington state amid mixed messages". Reuters. Retrieved December 14, 2012. 
  201. ^ Alan Duke (2012-11-08). "2 states legalize pot, but don't 'break out the Cheetos' yet". CNN.com. Retrieved 2013-01-02. 
  202. ^ "Marijuana clubs ring in new year in Colorado as legalized pot smoking begins". Abcnews.go.com. 2013-01-01. Retrieved 2013-01-02. 
  203. ^ Horward Mintz (2013-05-06). "Medical pot: California Supreme Court allows cities to ban weed dispensaries". Marin Independent Journal. Archived from the original on November 2, 2013. 
  204. ^ Vicky Baker. "Marijuana laws around the world: what you need to know". the Guardian. 
  205. ^ Uruguay pharmacies start selling cannabis straight to consumers | World news | The Guardian
  206. ^ "Uttarakhand To Become First Indian State To Legalise Cannabis Cultivation". Indiatimes. Retrieved 12 March 2017. 
  207. ^ Alchimia Blog, Medical marijuana news, December 2015
  208. ^ "Canadians facing pot charges in limbo, while Liberals work on legalization". The Globe and Mail. 
  209. ^ Parliament of the Czech Republic (1998), Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors (in Czech), Prague  "Podle čl. 36 Jednotné úmluvy o omamných látkách ze dne 31. března 1961 (č. 47/1965 Sb.) se signatáři zavazují k trestnímu postihu tam uvedených forem nakládání s drogami včetně jejich držby. Návrh upouští od dosavadní beztrestnosti držby omamných a psychotropních látek a jedů pro svoji potřebu. Dosavadní beztrestnost totiž eliminuje v řadě případů možnost postihu dealerů a distributorů drog."
  210. ^ Jorge G Castaneda. "The summit of muted intentions". aljazeera.com. 
  211. ^ "Congreso aprobó, en último debate, uso medicinal de la marihuana". 25 May 2016. 
  212. ^ "Dosis máximas de droga para consumo ya están vigentes" Archived 2013-07-06 at WebCite at El Comercio.com.
  213. ^ "Ecuador: Aprueban tenencia de drogas para consumo" Archived 2013-06-25 at the Wayback Machine. at El Nuevo Herald
  214. ^ "Ecuador could regulate the drug industry". Archived from the original on 2013-06-24. 
  215. ^ Ley de Narcomenudeo Archived 2010-11-30 at the Wayback Machine., El Pensador (in Spanish), 17 October 2009
  216. ^ Mexico: The Law Against Small-Scale Drug Dealing. A Doubtful Venture, Jorge Hernández Tinajero & Carlos Zamudio Angles, Series on Legislative Reform of Drug Policies Nr. 3, November 2009
  217. ^ "Drug policy profiles — Portugal" (PDF). 2011-06-01. Retrieved 2017-02-05. 
  218. ^ "Canada – Decriminalizing Marijuana, Survey" (PDF). 
  219. ^ a b c Jonathan P. Caulkins; Angela Hawken; Beau Kilmer; Mark. A.R. Kleiman. Marijuana Legalization: What Everyone Needs to Know. Oxford University Press. p. 16. ISBN 978-0199913732. 
  220. ^ a b Clark Davis Joshua (2015). "The business of getting high: head shops, countercultural capitalism, and the marijuana legalization movement". The Sixties. 8: 27–49. doi:10.1080/17541328.2015.1058480. 
  221. ^ "Daily marijuana use among college students highest since 1980". The University Record. 
  222. ^ Daniel Forbes (2002-11-19). "The Myth of Potent Pot". Slate.com. 
  223. ^ "World Drug Report 2006". United Nations Office on Drugs and Crime.  Ch. 2.3.
  224. ^ "Cannabis: Wholesale, street prices and purity levels" (PDF). UNODC.org. 2005. Retrieved 2013-01-09. 
  225. ^ "Report on U.S. Domestic Marijuana Production". NORML. Archived from the original on December 26, 2009. Retrieved 2010-01-02. 
  226. ^ "Marijuana Crop Reports". NORML. Archived from the original on December 31, 2009. Retrieved 2010-01-02. 
  227. ^ "Marijuana Called Top U.S. Cash Crop". 2008 ABCNews Internet Ventures. 
  228. ^ United Nations Office on Drugs and Crime (2008). World drug report (PDF). United Nations Publications. p. 264. ISBN 978-92-1-148229-4. 
  229. ^ European Monitoring Centre for Drugs and Drug Addiction (2008). Annual report: the state of the drugs problem in Europe (PDF). Luxembourg: Office for Official Publications of the European Communities. p. 38. ISBN 978-92-9168-324-6. 
  230. ^ a b "RAND study casts doubt on claims that marijuana acts as "gateway" to the use of cocaine and heroin". RAND Corporation. 2002-12-02. Archived from the original on 2006-11-04. 
  231. ^ Arthur Benavie (University of North Carolina) (2009). Drugs: America's Holy War. Routledge. pp. 90–. ISBN 978-0-7890-3840-1. 
  232. ^ "Public Views of Marijuana – Legalization, Decriminalization, Concerns | Pew Research Center for the People and the Press". 
  233. ^ Clayton J. Mosher; Scott Akins (2007). Drugs and Drug Policy: The Control of Consciousness Alteration. SAGE Publications. p. 18. ISBN 978-0-7619-3007-5. 
  234. ^ Saitz, Richard (2003-02-18). "Is marijuana a gateway drug?". Journal Watch. 2003 (218): 1. 
  235. ^ Degenhardt L, Coffey C, Carlin JB, Moran P, Patton GC (August 2007). "Who are the new amphetamine users? A 10-year prospective study of young Australians". Addiction. 102 (8): 1269–79. doi:10.1111/j.1360-0443.2007.01906.x. PMID 17624977. 
  236. ^ "3 The Experience of Drug Users". 2009/10 Scottish Crime and Justice Survey: Drug Use. The Scottish Government. 21 January 2011. Retrieved 5 November 2013. 
  237. ^ Morral AR, McCaffrey DF, Paddock SM (December 2002). "Reassessing the marijuana gateway effect". Addiction. 97 (12): 1493–504. doi:10.1046/j.1360-0443.2002.00280.x. PMID 12472629. 
  238. ^ "Marijuana Policy Project – FAQ". Archived from the original on 2008-06-22. 
  239. ^ Torabi MR, Bailey WJ, Majd-Jabbari M (September 1993). "Cigarette smoking as a predictor of alcohol and other drug use by children and adolescents: evidence of the "gateway drug effect"". The Journal of School Health. 63 (7): 302–6. doi:10.1111/j.1746-1561.1993.tb06150.x. PMID 8246462. 
  240. ^ Vanyukov MM, Tarter RE, Kirillova GP, Kirisci L, Reynolds MD, Kreek MJ, Conway KP, Maher BS, Iacono WG, Bierut L, Neale MC, Clark DB, Ridenour TA (June 2012). "Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective". Drug and Alcohol Dependence (Review). 123 Suppl 1: S3–17. doi:10.1016/j.drugalcdep.2011.12.018. PMC 3600369Freely accessible. PMID 22261179. 
  241. ^ "Marijuana Research". scientificamerican.com. 2004-11-22. Retrieved 2013-01-15. 
  242. ^ Ponto LL (May 2006). "Challenges of marijuana research". Brain. 129 (Pt 5): 1081–3. doi:10.1093/brain/awl092. PMID 16627464. 
  243. ^ Alok Jha (2012-05-31). "Ecstasy and cannabis should be freely available for study, says David Nutt". The Guardian. Retrieved 2013-01-15. 
  244. ^ "Medical Marijuana Policy in the United States". Stanford.edu. 2012-05-15. Retrieved 2013-01-15. 
  245. ^ "Research into marijuana's medical benefits limited; scientists cite challenge of studying an illegal drug". bostonglobe.com. 2012-10-19. Retrieved 2013-01-15. 
  246. ^ Peters EN, Budney AJ, Carroll KM (August 2012). "Clinical correlates of co-occurring cannabis and tobacco use: a systematic review". Addiction. 107 (8): 1404–17. doi:10.1111/j.1360-0443.2012.03843.x. PMC 3377777Freely accessible. PMID 22340422. 
  247. ^ "Does smoking cannabis cause cancer?". cancerresearchuk.org. 
  248. ^ Iseger TA, Bossong MG (March 2015). "A systematic review of the antipsychotic properties of cannabidiol in humans". Schizophrenia Research. 162 (1-3): 153–61. doi:10.1016/j.schres.2015.01.033. PMID 25667194. 
  249. ^ McLoughlin BC, Pushpa-Rajah JA, Gillies D, Rathbone J, Variend H, Kalakouti E, Kyprianou K (October 2014). "Cannabis and schizophrenia". The Cochrane Database of Systematic Reviews. 10 (10): CD004837. doi:10.1002/14651858.CD004837.pub3. PMC 4332954Freely accessible. PMID 25314586. 

External links

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