Calcineurin B homologous protein 1

CHP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E30
Identifiers
Aliases	CHP1, CHP, SLC9A1BP, Sid470p, p22, p24, calcineurin like EF-hand protein 1, SPAX9
External IDs	OMIM: 606988 MGI: 1927185 HomoloGene: 5235 GeneCards: CHP1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,230,839 bp[1] End 41,281,887 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,378,178 bp[2] End 119,417,508 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa vulva duodenum gums pons oral cavity body of tongue palpebral conjunctiva pylorus liver Top expressed in seminal vesicula dorsomedial hypothalamic nucleus pontine nuclei ventral tegmental area ventromedial nucleus subiculum lateral hypothalamus mammillary body median eminence paraventricular nucleus of hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding transporter activity microtubule binding protein kinase inhibitor activity metal ion binding calcium-dependent protein binding potassium channel regulator activity kinase binding protein binding Cellular component cytoplasm cytosol membrane focal adhesion microtubule cytoskeleton Golgi membrane plasma membrane transport vesicle endoplasmic reticulum extracellular exosome cytoskeleton endomembrane system nucleus endoplasmic reticulum-Golgi intermediate compartment Biological process negative regulation of protein phosphorylation positive regulation of protein glycosylation negative regulation of calcineurin-NFAT signaling cascade hyaluronan catabolic process negative regulation of protein autophosphorylation negative regulation of protein kinase activity positive regulation of sodium:proton antiporter activity negative regulation of phosphatase activity small GTPase mediated signal transduction protein stabilization cellular response to acidic pH membrane fusion regulation of intracellular pH positive regulation of protein transport negative regulation of protein ubiquitination potassium ion transport protein complex oligomerization microtubule bundle formation cytoplasmic microtubule organization protein export from nucleus membrane docking regulation of neuron death protein transport membrane organization negative regulation of NF-kappaB transcription factor activity calcium-ion regulated exocytosis positive regulation of protein targeting to membrane negative regulation of protein import into nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11261 56398 Ensembl ENSG00000187446 ENSMUSG00000014077 UniProt Q99653 P61022 RefSeq (mRNA) NM_007236 NM_019769 RefSeq (protein) NP_009167 NP_062743 Location (UCSC) Chr 15: 41.23 – 41.28 Mb Chr 2: 119.38 – 119.42 Mb PubMed search [3] [4]
Wikidata
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Calcineurin B homologous protein 1 is a protein encoded in humans by the CHP1 gene (formerly CHP).^[5]

Function

The protein encoded by this gene is a phosphoprotein that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.^[5]

Interactions

Calcineurin B homologous protein 1 has been shown to interact with

• sodium-hydrogen antiporter 1,^[6][7][8]
• sodium-hydrogen antiporter 3,^[6] and
• sodium-hydrogen anti porter 9.^[9]

References

Further reading

External links

• Human CHP1 genome location and CHP1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 1 May 2022, at 18:48