Protein-coding gene in the species Homo sapiens
Calmegin , also known as CLGN , is a protein which in humans is encoded by the CLGN gene .[5] [6]
Function Calmegin is a testis -specific endoplasmic reticulum chaperone protein . CLGN may play a role in spermatogeneisis and infertility .[5]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000153132 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002190 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: CLGN calmegin" .^ Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y (March 1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development" . J. Biol. Chem . 269 (10): 7744–7749. doi :10.1016/S0021-9258(17)37349-0 PMID 8126001 .
Further reading
Watanabe D, Yamada K, Nishina Y, et al. (1994). "Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development" . J. Biol. Chem . 269 (10): 7744–7749. doi :10.1016/S0021-9258(17)37349-0 PMID 8126001 . Ikawa M, Wada I, Kominami K, et al. (1997). "The putative chaperone calmegin is required for sperm fertility". Nature . 387 (6633): 607–611. Bibcode :1997Natur.387..607I . doi :10.1038/42484 . PMID 9177349 . S2CID 4347203 . Tanaka H, Ikawa M, Tsuchida J, et al. (1998). "Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone". Gene . 204 (1–2): 159–163. doi :10.1016/S0378-1119(97)00537-4 . PMID 9434179 . Yoshinaga K, Tanii I, Toshimori K (1999). "Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis" . Arch. Histol. Cytol . 62 (3): 283–293. doi :10.1679/aohc.62.283 PMID 10495883 . Ikawa M, Nakanishi T, Yamada S, et al. (2002). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility" . Dev. Biol . 240 (1): 254–261. doi :10.1006/dbio.2001.0462 PMID 11784061 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–16903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–45. doi :10.1038/ng1285 PMID 14702039 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–2127. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kim DH, Shim JS, Kwon HJ (2005). "Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase" . Experimental & Molecular Medicine 37 (5): 492–496. doi :10.1038/emm.2005.61 PMID 16264275 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
This page was last edited on 13 October 2022, at 06:00
This page was last edited on 13 October 2022, at 06:00