CLDN17

CLDN17

Identifiers

CLDN17, claudin 17

External IDs

OMIM: 617005 MGI: 2652030 HomoloGene: 8116 GeneCards: CLDN17

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q21.3	Start	30,165,565 bp^[1]
Band	21q21.3	End	30,166,805 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C3.3	Start	88,302,695 bp^[2]
Band	16\|16 C3.3	End	88,303,866 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

cervix epithelium

oral cavity

human penis

epithelium of esophagus

gums

vagina

body of tongue

vulva

thymus

minor salivary glands

Top expressed in

esophagus

surface ectoderm

nose

stomach

zone of skin

visual system

limb

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	structural molecule activity identical protein binding chloride channel activity protein binding
Cellular component	integral component of membrane cell junction plasma membrane membrane bicellular tight junction chloride channel complex
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ion transport chloride transport chloride transmembrane transport transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


26285


239931

Ensembl


ENSG00000156282


ENSMUSG00000055811

UniProt


P56750


Q8BXA6

RefSeq (mRNA)


NM_012131


NM_181490

RefSeq (protein)


NP_036263


NP_852467

Location (UCSC)

Chr 21: 30.17 – 30.17 Mb

Chr 16: 88.3 – 88.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.^[5]^[6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.^[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156282 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055811 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
^ "Entrez Gene: CLDN17 claudin 17".
^ Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427.
^ Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMID 22402829. S2CID 18173604.
^ Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi:10.3390/cells11111782. PMC 9180152. PMID 35681477.

External links

Human CLDN17 genome location and CLDN17 gene details page in the UCSC Genome Browser.

González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandner JM, Kief S, Grund C, et al. (2003). "Organization and formation of the tight junction system in human epidermis and cultured keratinocytes". Eur. J. Cell Biol. 81 (5): 253–63. doi:10.1078/0171-9335-00244. PMID 12067061.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

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This page was last edited on 3 December 2023, at 01:47

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References

External links

Further reading