CCT8

CCT8

Identifiers

CCT8, C21orf112, Cctq, D21S246, PRED71, chaperonin containing TCP1 subunit 8

External IDs

OMIM: 617786 MGI: 107183 HomoloGene: 4802 GeneCards: CCT8

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q21.3	Start	29,055,805 bp^[1]
Band	21q21.3	End	29,073,797 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C3.3	Start	87,280,214 bp^[2]
Band	16\|16 C3.3	End	87,292,761 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

secondary oocyte

embryo

ganglionic eminence

endothelial cell

germinal epithelium

islet of Langerhans

parietal pleura

right adrenal gland

visceral pleura

Top expressed in

otic placode

maxillary prominence

saccule

somite

primitive streak

abdominal wall

spermatocyte

neural tube

hand

dermis

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein binding ATP binding protein folding chaperone activity unfolded protein binding cadherin binding
Cellular component	cell body cytosol centrosome cell projection cilium nucleoplasm microtubule organizing center zona pellucida receptor complex intermediate filament cytoskeleton microtubule extracellular exosome cytoskeleton cytoplasm chaperonin-containing T-complex extracellular region secretory granule lumen azurophil granule lumen ficolin-1-rich granule lumen
Biological process	positive regulation of protein localization to Cajal body positive regulation of establishment of protein localization to telomere pore complex assembly protein stabilization positive regulation of telomere maintenance via telomerase toxin transport positive regulation of telomerase RNA localization to Cajal body binding of sperm to zona pellucida protein folding 'de novo' protein folding neutrophil degranulation chaperone-mediated protein folding
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10694


12469

Ensembl


ENSG00000156261


ENSMUSG00000025613

UniProt


P50990


P42932

RefSeq (mRNA)


NM_006585 NM_001282907 NM_001282908 NM_001282909


NM_009840

RefSeq (protein)


NP_001269836 NP_001269837 NP_001269838 NP_006576


NP_033970

Location (UCSC)

Chr 21: 29.06 – 29.07 Mb

Chr 16: 87.28 – 87.29 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene.^[5]^[6] The CCT8 protein is a component of the TRiC complex.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156261 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025613 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kubota H, Hynes G, Willison K (Apr 1995). "The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1". Gene. 154 (2): 231–6. doi:10.1016/0378-1119(94)00880-2. PMID 7890169.
^ "Entrez Gene: CCT8 chaperonin containing TCP1, subunit 8 (theta)".

External links

Human CCT8 genome location and CCT8 gene details page in the UCSC Genome Browser.

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Yamazaki M, Ono A, Watanabe K, et al. (1996). "Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21". DNA Res. 2 (4): 187–9. doi:10.1093/dnares/2.4.187. PMID 8590283.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Hynes GM, Willison KR (2000). "Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin". J. Biol. Chem. 275 (25): 18985–94. doi:10.1074/jbc.M910297199. PMID 10748209.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 3 December 2023, at 01:41

From Wikipedia, the free encyclopedia

See also

References

External links

Further reading